Search Results - "Joffre, Olivier P."

Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin by Sancho, David, Mourão-Sá, Diego, Joffre, Olivier P, Schulz, Oliver, Rogers, Neil C, Pennington, Daniel J, Carlyle, James R, Reis e Sousa, Caetano

“…The mouse CD8alpha+ DC subset excels at cross-presentation of antigen, which can elicit robust CTL responses. A receptor allowing specific antigen targeting to…”
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The type 1 diabetes susceptibility locus Idd5 favours robust neonatal development of highly autoreactive regulatory T cells in the NOD mouse by Santamaria, Jérémy C, Vuillier, Sylvia, Galindo-Albarrán, Ariel O, Castan, Sarah, Detraves, Claire, Joffre, Olivier P, Romagnoli, Paola, van Meerwijk, Joost P M

“…Regulatory T lymphocytes expressing the transcription factor Foxp3 (Tregs) play an important role in the prevention of autoimmune diseases and other…”
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IL-2 and IL-15 drive intrathymic development of distinct periphery-seeding CD4+Foxp3+ regulatory T lymphocytes by Apert, Cécile, Galindo-Albarrán, Ariel O., Castan, Sarah, Detraves, Claire, Michaud, Héloise, McJannett, Nicola, Haegeman, Bart, Fillatreau, Simon, Malissen, Bernard, Holländer, Georg, Žuklys, Saulius, Santamaria, Jérémy C., Joffre, Olivier P., Romagnoli, Paola, van Meerwijk, Joost P. M.

“…Development of Foxp3-expressing regulatory T-lymphocytes (Treg) in the thymus is controlled by signals delivered in T-cell precursors via the TCR,…”
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Cross-presentation by dendritic cells by Joffre, Olivier P., Segura, Elodie, Savina, Ariel, Amigorena, Sebastian

“…Key Points Two main pathways have been described for cross-presentation: the cytosolic pathway, in which antigen processing occurs in the cytosol, and the…”
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Peripheral regulatory T lymphocytes recirculating to the thymus suppress the development of their precursors by Thiault, Nicolas, Darrigues, Julie, Adoue, Véronique, Gros, Marine, Binet, Bénédicte, Perals, Corine, Leobon, Bertrand, Fazilleau, Nicolas, Joffre, Olivier P, Robey, Ellen A, van Meerwijk, Joost P M, Romagnoli, Paola

“…Regulatory T cells (T reg cells) can suppress autoreactive immune responses in the periphery. Joost van Meerwijk and colleagues show that activated peripheral…”
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The Histone Methyltransferase SETDB1 Controls T Helper Cell Lineage Integrity by Repressing Endogenous Retroviruses by Adoue, Véronique, Binet, Bénédicte, Malbec, Agathe, Fourquet, Joanna, Romagnoli, Paola, van Meerwijk, Joost P.M., Amigorena, Sebastian, Joffre, Olivier P.

“…Upon activation, naive CD4+ T cells differentiate into distinct T cell subsets via processes reliant on epigenetically regulated, lineage-specific…”
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Identification of a dendritic cell receptor that couples sensing of necrosis to immunity by Joffre, Olivier P, Keller, Anna M, Rosewell, Ian, Rogers, Neil C, Martínez, Dolores, Sousa, Caetano Reis e, Sancho, David, Hernanz-Falcón, Patricia

“…Injury or impaired clearance of apoptotic cells leads to the pathological accumulation of necrotic corpses, which induce an inflammatory response that…”
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Efficient and versatile manipulation of the peripheral CD4+ T‐cell compartment by antigen targeting to DNGR‐1/CLEC9A by Joffre, Olivier P., Sancho, David, Zelenay, Santiago, Keller, Anna M., Reis e Sousa, Caetano

“…DC NK lectin group receptor‐1 (DNGR‐1, also known as CLEC9A) is a C‐type lectin receptor expressed by mouse CD8α+ DC and by their putative equivalents in…”
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Single-cell RNA sequencing identifies senescence as therapeutic target in rhabdomyolysis-induced acute kidney injury by Rao, Snigdha N, Zahm, Margot, Casemayou, Audrey, Buleon, Marie, Faguer, Stanislas, Feuillet, Guylène, Iacovoni, Jason S, Joffre, Olivier P, Gonzalez-Fuentes, Ignacio, Lhuillier, Emeline, Martins, Frédéric, Riant, Elodie, Zakaroff-Girard, Alexia, Schanstra, Joost P, Saulnier-Blache, Jean Sébastien, Belliere, Julie

“…ABSTRACT Background The role of macrophages in the development of rhabdomyolysis-induced acute kidney injury (RM-AKI) has been established, but an in-depth…”
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Robust intrathymic development of regulatory T cells in young NOD mice is rapidly restrained by recirculating cells by Darrigues, Julie, Santamaria, Jeremy C., Galindo‐Albarrán, Ariel, Robey, Ellen A., Joffre, Olivier P., van Meerwijk, Joost P.M., Romagnoli, Paola

“…Regulatory T lymphocytes (Treg) play a vital role in the protection of the organism against autoimmune pathology. It is therefore paradoxical that…”
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The Repertoire of Newly Developing Regulatory T Cells in the Type 1 Diabetes–Prone NOD Mouse Is Very Diverse by Galindo-Albarrán, Ariel, Castan, Sarah, Santamaria, Jérémy C., Joffre, Olivier P., Haegeman, Bart, Romagnoli, Paola, van Meerwijk, Joost P.M.

“…Regulatory T lymphocytes expressing the forkhead/winged helix transcription factor Foxp3 (Treg) play a vital role in the protection of the organism from…”
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The Repertoire of Newly Developing Regulatory T Cells in the Type 1 Diabetes–Prone NOD Mouse Is Very Diverse by Galindo-Albarrán, Ariel, Castan, Sarah, Santamaria, Jérémy C, Joffre, Olivier P, Haegeman, Bart, Romagnoli, Paola, van Meerwijk, Joost P M

“…Regulatory T lymphocytes expressing the forkhead/winged helix transcription factor Foxp3 (Treg) play a vital role in the protection of the organism from…”
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