Search Results - "Joetham, A"

Dysregulation of metabolic pathways in a mouse model of allergic asthma by Quinn, K. D., Schedel, M., Nkrumah‐Elie, Y., Joetham, A., Armstrong, M., Cruickshank‐Quinn, C., Reisdorph, R., Gelfand, E. W., Reisdorph, N.

“…Background Asthma is a complex lung disease resulting from the interplay of genetic and environmental factors. To understand the molecular changes that occur…”
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Development of eosinophilic airway inflammation and airway hyperresponsiveness in mast cell-deficient mice by Takeda, K, Hamelmann, E, Joetham, A, Shultz, L D, Larsen, G L, Irvin, C G, Gelfand, E W

“…Mast cells are the main effector cells of immediate hypersensitivity and anaphylaxis. Their role in the development of allergen-induced airway…”
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IL-10 Is Necessary for the Expression of Airway Hyperresponsiveness but Not Pulmonary Inflammation after Allergic Sensitization by Makela, M. J., Kanehiro, A., Borish, L., Dakhama, A., Loader, J., Joetham, A., Xing, Z., Jordana, M., Larsen, G. L., Gelfand, E. W.

“…Cytokines play an important role in modulating inflammatory responses and, as a result, airway tone. IL-10 is a regulatory cytokine that has been suggested for…”
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Effects of combination therapy with montelukast and carbocysteine in allergen‐induced airway hyperresponsiveness and airway inflammation by Takeda, K, Shiraishi, Y, Matsubara, S, Miyahara, N, Matsuda, H, Okamoto, M, Joetham, A, Gelfand, EW

“…Background and purpose:  Montelukast and S‐carbocysteine have been used in asthmatic patients as an anti‐inflammatory or mucolytic agent respectively…”
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IL-4 Controls The Phenotypic Conversion Of Effector Memory CD8+ T Cells To IL-13-Producing Cells That Enhance Allergen-Induced Airway Hyperresponsiveness And Inflammation by Jia, Y, Takeda, K, Han, J, Joetham, A, Lucas, J.J, Gelfand, E.W

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A Murine IL-4 Receptor Antagonist That Inhibits IL-4- and IL-13-Induced Responses Prevents Antigen-Induced Airway Eosinophilia and Airway Hyperresponsiveness by Tomkinson, A, Duez, C, Cieslewicz, G, Pratt, J. C, Joetham, A, Shanafelt, M.-C, Gundel, R, Gelfand, E. W

“…The closely related Th2 cytokines, IL-4 and IL-13, share many biological functions that are considered important in the development of allergic airway…”
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Anti-interleukin 5 but not anti-ige prevents airway inflammation and airway hyperresponsiveness by HAMELMANN, E, CIESLEWICZ, G, SCHWARZE, J, ISHIZUKA, T, JOETHAM, A, HEUSSER, C, GELFAND, E. W

“…The role of IL-5 and allergen-specific IgE in the development of eosinophilic airway inflammation and airway hyperresponsiveness (AHR) was investigated in a…”
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Role of CD8+ Effector Memory T Cell-Derived IL-6 in the Development of Airway Hyperresponsiveness and Inflammation by Jia, Y, Takeda, K, Han, J, Joetham, A, Lucas, J.J, Gelfand, E.W

“…CD8+ effector memory T cells (Teff) restore airway hyperresponsiveness (AHR) and inflammation in CD8-deficient (CD8-/-) mice (Nat Med 2004:865), and was…”
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Development of Peanut-Induced Intestinal Allergy is Dependent on the Mast Cell-IgE-FcϵRI-IL-13 Pathway by Wang, M, Takeda, K, Shiraishi, Y, Okamoto, M, Dakhama, A, Joetham, A, Gelfand, E.W

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Jagged1, a Ligand for Notch Receptor Expressed on Dendritic Cells, Regulates Airway Hyperresponsiveness and Inflammation by Initiating Th2 Responses by Okamoto, M, Takeda, K, Matsuda, H, Joetham, A, Domenico, J, Lucas, J.J, Gelfand, E.W

“…Bone marrow-derived dendritic cells (BMDC) were cultured with purified LPS-free ovalbumin (OVA) with/without added LPS and analyzed for Notch ligand expression…”
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Importance of Both Allergen-Specific (ANR) and Non-Specific Nasal Reactivity (NNR) in the Development of Early- and Late-Phase Nasal Responses by Miyahara, S, Miyahara, N, Matsubara, S, Joetham, A, Gelfand, E.W

“…Allergen-specific (ANR) and allergen non-specific (NNR) nasal responses have been investigated separately, and it remains unclear how the NNR component…”
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Treatment of RSV-Infected Newborn Mice With Anti-IgE Antibody Attenuates the Subsequent Enhancement of Airway Hyperresponsiveness on Re-Infection by Dakhama, A, Lee, Y, Balhorn, A, Joetham, A, Gelfand, E.W

“…RSV-specific IgE antibodies enhance airway hyperresponsiveness (AHR) in mice (AJRCCM 2004, 170:952) and neonatal RSV infection predisposes to the development…”
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Fexofenadine reverses established allergen-induced airway disease by Joetham, A., Takeda, K., Gelfand, E.W.

“…The aim of this study was to determine the efficacy of fexofenadine in reversing established airway hyperresponsiveness and in normalizing ongoing…”
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Reduction of allergic airway responses in P-selectin-deficient mice by De Sanctis, George T, Wolyniec, Walter W, Green, Francis H. Y, Qin, Shixin, Jiao, Aiping, Finn, Patricia W, Noonan, Thomas, Joetham, Anthony A, Gelfand, Erwin, Doerschuk, Claire M, Drazen, Jeffrey M

“…George T. De Sanctis 1 , Walter W. Wolyniec 2 , Francis H. Y. Green 3 , Shixin Qin 4 , Aiping Jiao 1 , Patricia W. Finn 1 , Thomas Noonan 2 , Anthony A…”
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The Role of Notch in Effector Memory CD8+ T Cell Development of Airway Hyperresponsiveness by Okamoto, M, Takeda, K, Joetham, A, Ohnishi, H, Matsuda, H, Swasey, C.H, Dakhama, A, Gelfand, E.W

“…Results Both C57Bl/6 and CD8-/- mice, recipients of GSI-treated TEFF, developed lower levels of AHR and reduced numbers of eosinophils and IL-13, accompanied…”
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Critical Roles for Interleukin-4 and Interleukin-5 during Respiratory Syncytial Virus Infection in the Development of Airway Hyperresponsiveness after Airway Sensitization by SCHWARZE, JURGEN, CIESLEWICZ, GRZEGORZ, JOETHAM, ANTHONY, IKEMURA, TOSHIHIDE, MAKELA, MIKA J, DAKHAMA, AZZEDDINE, SHULTZ, LEONARD D, LAMERS, MARINUS C, GELFAND, ERWIN W

“…In mice, respiratory syncytial virus (RSV) infection can enhance the consequences of allergic airway sensitization, resulting in lung eosinophilia and the…”
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Combination of Interleukin (IL)-2 and IL-18 Attenuates Allergen-Induced Airway Hyperresponsiveness (AHR) and Inflammation through An IL-12-STAT4-Interferon (IFN)-gamma Pathway by Matsubara, S., Takeda, K., Kodama, T., Koya, T., Miyahara, N., Joetham, A., Swasey, C.H., Dakhama, A., Gelfand, E.W.

“…C57BL/6, IFN-gamma-deficient and signal transducer and activator of transcription (STAT)4-deficient mice were sensitized to ovalbumin (OVA) and challenged with…”
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Role of Endogenous Estrogen in Regulating Airway Hyperresponsiveness Induced by Allergen Inhalation Without Adjuvant by Matsubara, S, Swasey, C.H, Dakhama, A, Loader, J.E, Ohnishi, H, Joetham, A, Balhorn, A, Miyahara, N, Takeda, K, Gelfand, E.W

“…OVA-exposed male mice showed significant (p<0.01) increases in airway responsiveness to inhaled MCh, but AHR could not be detected in female mice…”
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In Vitro and in Vivo Effects of IL-10-Treated Dendritic Cells on Airway Allergic Inflammation by Koya, T., Takeda, K., Matsubara, S., Miyahara, N., Miyahara, S., Swasey, C., Barhorn, A., Joetham, A., Dakhama, A., Gelfand, E.W.

“…Myeloid DCs (mDCs) were generated from bone marrow cells of C57BL/6 mice co-cultured with GM-CSF and IL-4 in the presence (IL-10+mDCs) or absence (IL-10-mDC)…”
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STAT4 deficiency exaggerates airway hyperresponsiveness (AHR) after repeated ovalbumin (OVA) challenge by Matsubara, S., Kodama, T., Takeda, K., Miyahara, N., Joetham, A., Taube, C., Dakhama, A., Park, J., Koya, T., Gelfand, E.W.

“…STAT4-deficient mice and their congenic littermates were sensitized to OVA by intraperitoneal injection (twice) and subsequently challenged (via the airways)…”
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