Search Results - "Joensuu, Heikki"

Gastrointestinal Stromal Tumors by von Mehren, Margaret, Joensuu, Heikki

“…GI stromal tumors (GISTs) are neoplasms with a varying malignancy potential ranging from virtually indolent tumors to rapidly progressing cancers. GISTs occur…”
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Adjuvant treatment of GIST: patient selection and treatment strategies by Joensuu, Heikki

“…Tyrosine kinase inhibitors, such as imatinib, are effective treatments of advanced-stage gastrointestinal stromal tumour. Here, the optimal treatment strategy…”
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Risk stratification of patients diagnosed with gastrointestinal stromal tumor by Joensuu, Heikki, MD, PhD

“…Summary Accurate risk stratification of gastrointestinal stromal tumors (GISTs) has become increasingly important owing to emerging adjuvant systemic…”
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Gastrointestinal stromal tumour by Joensuu, Heikki, Prof, Hohenberger, Peter, MD, Corless, Christopher L, MD

“…Summary Gastrointestinal stromal tumours (GISTs) are mesenchymal neoplasms that arise in the gastrointestinal tract, usually in the stomach or the small…”
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Darolutamide and Survival in Metastatic, Hormone-Sensitive Prostate Cancer by Smith, Matthew R, Hussain, Maha, Saad, Fred, Fizazi, Karim, Sternberg, Cora N, Crawford, E. David, Kopyltsov, Evgeny, Park, Chandler H, Alekseev, Boris, Montesa-Pino, Álvaro, Ye, Dingwei, Parnis, Francis, Cruz, Felipe, Tammela, Teuvo L.J, Suzuki, Hiroyoshi, Utriainen, Tapio, Fu, Cheng, Uemura, Motohide, Méndez-Vidal, María J, Maughan, Benjamin L, Joensuu, Heikki, Thiele, Silke, Li, Rui, Kuss, Iris, Tombal, Bertrand

“…Standard therapy for metastatic, hormone-sensitive prostate cancer is androgen-deprivation therapy, usually with docetaxel. A large, multinational, phase 3…”
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Tumor-Infiltrating Lymphocytes and Prognosis: A Pooled Individual Patient Analysis of Early-Stage Triple-Negative Breast Cancers by Loi, Sherene, Drubay, Damien, Adams, Sylvia, Pruneri, Giancarlo, Francis, Prudence A, Lacroix-Triki, Magali, Joensuu, Heikki, Dieci, Maria Vittoria, Badve, Sunil, Demaria, Sandra, Gray, Robert, Munzone, Elisabetta, Lemonnier, Jerome, Sotiriou, Christos, Piccart, Martine J, Kellokumpu-Lehtinen, Pirkko-Liisa, Vingiani, Andrea, Gray, Kathryn, Andre, Fabrice, Denkert, Carsten, Salgado, Roberto, Michiels, Stefan

“…The aim of the current study was to conduct a pooled analysis of studies that have investigated the prognostic value of tumor-infiltrating lymphocytes (TILs)…”
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Emerging Agents for the Treatment of Advanced, Imatinib-Resistant Gastrointestinal Stromal Tumors: Current Status and Future Directions by Bauer, Sebastian, Joensuu, Heikki

“…Imatinib is strongly positioned as the recommended first-line agent for most patients with advanced gastrointestinal stromal tumor (GIST) due to its good…”
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The Management of Gastrointestinal Stromal Tumors: A Model for Targeted and Multidisciplinary Therapy of Malignancy by Joensuu, Heikki, DeMatteo, Ronald P

“…Gastrointestinal stromal tumor (GIST) has become a model for targeted therapy in cancer. The vast majority of GISTs contain an activating mutation in either…”
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Boron neutron capture therapy for locally recurrent head and neck squamous cell carcinoma: An analysis of dose response and survival by Koivunoro, Hanna, Kankaanranta, Leena, Seppälä, Tiina, Haapaniemi, Aaro, Mäkitie, Antti, Joensuu, Heikki

“…•Boron neutron capture therapy (BNCT) was effective in the treatment of locally recurred inoperable squamous cell head and neck cancer despite conventional…”
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Human breast cancer cells educate macrophages toward the M2 activation status by Sousa, Sofia, Brion, Régis, Lintunen, Minnamaija, Kronqvist, Pauliina, Sandholm, Jouko, Mönkkönen, Jukka, Kellokumpu-Lehtinen, Pirkko-Liisa, Lauttia, Susanna, Tynninen, Olli, Joensuu, Heikki, Heymann, Dominique, Määttä, Jorma A

“…The immune system plays a major role in cancer progression. In solid tumors, 5-40 % of the tumor mass consists of tumor-associated macrophages (TAMs) and there…”
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Cancer-derived exosomes from HER2-positive cancer cells carry trastuzumab-emtansine into cancer cells leading to growth inhibition and caspase activation by Barok, Mark, Puhka, Maija, Vereb, Gyorgy, Szollosi, Janos, Isola, Jorma, Joensuu, Heikki

“…Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate that carries a cytotoxic drug (DM1) to HER2-positive cancer. The target of T-DM1 (HER2) is present…”
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Systemic chemotherapy for cancer: from weapon to treatment by Joensuu, Heikki, Prof

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Deep learning identifies morphological features in breast cancer predictive of cancer ERBB2 status and trastuzumab treatment efficacy by Bychkov, Dmitrii, Linder, Nina, Tiulpin, Aleksei, Kücükel, Hakan, Lundin, Mikael, Nordling, Stig, Sihto, Harri, Isola, Jorma, Lehtimäki, Tiina, Kellokumpu-Lehtinen, Pirkko-Liisa, von Smitten, Karl, Joensuu, Heikki, Lundin, Johan

“…The treatment of patients with ERBB2 (HER2)-positive breast cancer with anti- ERBB2 therapy is based on the detection of ERBB2 gene amplification or protein…”
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Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy by Haikala, Heidi M., Anttila, Johanna M., Marques, Elsa, Raatikainen, Tiina, Ilander, Mette, Hakanen, Henna, Ala-Hongisto, Hanna, Savelius, Mariel, Balboa, Diego, Von Eyss, Bjoern, Eskelinen, Vilja, Munne, Pauliina, Nieminen, Anni I., Otonkoski, Timo, Schüler, Julia, Laajala, Teemu D., Aittokallio, Tero, Sihto, Harri, Mattson, Johanna, Heikkilä, Päivi, Leidenius, Marjut, Joensuu, Heikki, Mustjoki, Satu, Kovanen, Panu, Eilers, Martin, Leverson, Joel D., Klefström, Juha

“…Elevated MYC expression sensitizes tumor cells to apoptosis but the therapeutic potential of this mechanism remains unclear. We find, in a model of MYC-driven…”
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Predicting recurrence-free survival after surgery for GIST by Joensuu, Heikki

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CD73 Promotes Resistance to HER2/ErbB2 Antibody Therapy by Turcotte, Martin, Allard, David, Mittal, Deepak, Bareche, Yacine, Buisseret, Laurence, José, Vinu, Pommey, Sandra, Delisle, Vincent, Loi, Sherene, Joensuu, Heikki, Kellokumpu-Lehtinen, Pirkko-Liisa, Sotiriou, Christos, Smyth, Mark J, Stagg, John

“…Expression of the ectonucleotidase CD73 by tumor cells, stromal cells, and immune cells is associated in cancer with immune suppression. In this study, we…”
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L-type calcium channels regulate filopodia stability and cancer cell invasion downstream of integrin signalling by Jacquemet, Guillaume, Baghirov, Habib, Georgiadou, Maria, Sihto, Harri, Peuhu, Emilia, Cettour-Janet, Pierre, He, Tao, Perälä, Merja, Kronqvist, Pauliina, Joensuu, Heikki, Ivaska, Johanna

“…Mounting in vitro , in vivo and clinical evidence suggest an important role for filopodia in driving cancer cell invasion. Using a high-throughput…”
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SORLA regulates endosomal trafficking and oncogenic fitness of HER2 by Pietilä, Mika, Sahgal, Pranshu, Peuhu, Emilia, Jäntti, Niklas Z., Paatero, Ilkka, Närvä, Elisa, Al-Akhrass, Hussein, Lilja, Johanna, Georgiadou, Maria, Andersen, Olav M., Padzik, Artur, Sihto, Harri, Joensuu, Heikki, Blomqvist, Matias, Saarinen, Irena, Boström, Peter J., Taimen, Pekka, Ivaska, Johanna

“…The human epidermal growth factor receptor 2 (HER2) is an oncogene targeted by several kinase inhibitors and therapeutic antibodies. While the endosomal…”
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Adjuvant Imatinib for High-Risk GI Stromal Tumor: Analysis of a Randomized Trial by Joensuu, Heikki, Eriksson, Mikael, Sundby Hall, Kirsten, Reichardt, Annette, Hartmann, Jörg T, Pink, Daniel, Ramadori, Giuliano, Hohenberger, Peter, Al-Batran, Salah-Eddin, Schlemmer, Marcus, Bauer, Sebastian, Wardelmann, Eva, Nilsson, Bengt, Sihto, Harri, Bono, Petri, Kallio, Raija, Junnila, Jouni, Alvegård, Thor, Reichardt, Peter

“…Three years of adjuvant imatinib therapy are recommended for patients with GI stromal tumor (GIST) with high-risk features, according to survival findings in…”
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Compressive stress-mediated p38 activation required for ERα + phenotype in breast cancer by Munne, Pauliina M., Martikainen, Lahja, Räty, Iiris, Bertula, Kia, Nonappa, Ruuska, Janika, Ala-Hongisto, Hanna, Peura, Aino, Hollmann, Babette, Euro, Lilya, Yavuz, Kerim, Patrikainen, Linda, Salmela, Maria, Pokki, Juho, Kivento, Mikko, Väänänen, Juho, Suomi, Tomi, Nevalaita, Liina, Mutka, Minna, Kovanen, Panu, Leidenius, Marjut, Meretoja, Tuomo, Hukkinen, Katja, Monni, Outi, Pouwels, Jeroen, Sahu, Biswajyoti, Mattson, Johanna, Joensuu, Heikki, Heikkilä, Päivi, Elo, Laura L., Metcalfe, Ciara, Junttila, Melissa R., Ikkala, Olli, Klefström, Juha

“…Breast cancer is now globally the most frequent cancer and leading cause of women’s death. Two thirds of breast cancers express the luminal estrogen…”
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