Search Results - "Joel, Simon P."

The Association of CCND1 Overexpression and Cisplatin Resistance in Testicular Germ Cell Tumors and Other Cancers by Noel, Elodie E, Yeste-Velasco, Marc, Mao, Xueying, Perry, Jackie, Kudahetti, Sakunthala C, Li, Ningfeng F, Sharp, Swee, Chaplin, Tracy, Xue, Liyan, McIntyre, Alan, Shan, Ling, Powles, Thomas, Oliver, R. Tim D, Young, Bryan D, Shipley, Janet, Berney, Daniel M, Joel, Simon P, Lu, Yong-Jie

“…Development of chemoresistance limits the clinical efficiency of platinum-based therapy. Although many resistance mechanisms have been demonstrated,…”
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The proteasome inhibitor bortezomib acts independently of p53 and induces cell death via apoptosis and mitotic catastrophe in B-cell lymphoma cell lines by STRAUSS, Sandra J, HIGGINBOTTOM, Karen, JÜLIGER, Simone, MAHARAJ, Lenushka, ALLEN, Paul, SCHENKEIN, David, LISTER, T. Andrew, JOEL, Simon P

“…Bortezomib is a proteasome inhibitor with proven efficacy in multiple myeloma and non-Hodgkin's lymphoma. This study reports the effects of bortezomib in…”
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Bortezomib Therapy in Patients With Relapsed or Refractory Lymphoma: Potential Correlation of In Vitro Sensitivity and Tumor Necrosis Factor Alpha Response With Clinical Activity by STRAUSS, Sandra J, MAHARAJ, Lenushka, SCHENKEIN, David, BALKWILL, Frances, JOEL, Simon P, LISTER, T. Andrew, HOARE, Susan, JOHNSON, Peter W, RADFORD, John A, VINNECOMBE, Sarah, MILLARD, Lynda, ROHATINER, Ama, BORAL, Anthony, TREHU, Elizabeth

“…To determine the efficacy of bortezomib in patients with lymphoid malignancy, correlating clinical response with effect on plasma cytokines and in vitro…”
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Raman spectroscopic analysis of breast cancer tissues: identifying differences between normal, invasive ductal carcinoma and ductal carcinoma in situ of the breast tissue by Rehman, Shazza, Movasaghi, Zanyar, Tucker, Art T., Joel, Simon P., Darr, Jawwad A., Ruban, Alexander V., Rehman, Ihtesham U.

“…A relatively non‐destructive method employing Raman spectroscopy for the analysis of histopathological specimens is described. Raman spectroscopy has allowed…”
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Capabilities of HPLC with APEX-Q nebulisation ICP-MS and ESI MS/MS to compare selenium uptake and speciation of non-malignant with different B cell lymphoma lines by Goenaga-Infante, Heidi, Kassam, Shireen, Stokes, Emma, Hopley, Christopher, Joel, Simon P

“…The formation of intracellular dimethylselenide (DMSe) as a product of exposure of non-malignant (PBMCs) and lymphoma (RL and DHL-4) cell lines to…”
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Repression of sphingosine kinase (SK)-interacting protein (SKIP) in acute myeloid leukemia diminishes SK activity and its re-expression restores SK function by Ghazaly, Essam A., Miraki-Moud, Farideh, Smith, Paul, Gnanaranjan, Chathunissa, Koniali, Lola, Oke, Adedayo, Saied, Marwa H., Petty, Robert, Matthews, Janet, Stronge, Randal, Joel, Simon P., Young, Bryan D., Gribben, John, Taussig, David C.

“…Previous studies have shown that sphingosine kinase interacting protein (SKIP) inhibits sphingosine kinase (SK) function in fibroblasts. SK phosphorylates…”
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DNA damage is able to induce senescence in tumor cells in vitro and in vivo by TE POELE, Robert H, OKOROKOV, Andrei L, JARDINE, Lesley, CUMMINGS, Jeffrey, JOEL, Simon P

“…Often the use of cytotoxic drugs in cancer therapy results in stable disease rather than regression of the tumor, and this is typically seen as a failure of…”
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Phase I and Pharmacokinetic Study of Intravenous Irinotecan Plus Oral Ciclosporin in Patients With Fluorouracil-Refractory Metastatic Colon Cancer by CHESTER, John D, JOEL, Simon P, CHEESEMAN, Susan L, HALL, Geoffrey D, BRAUN, Michael S, PERRY, Jackie, DAVIS, Theresa, BUTTON, Christopher J, SEYMOUR, Matthew T

“…Purpose: To assess the safety and toxicity profile of escalating doses of intravenous irinotecan, in combination with a fixed dose of oral ciclosporin (Cs) and…”
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Methylseleninic acid inhibits HDAC activity in diffuse large B-cell lymphoma cell lines by Kassam, Shireen, Goenaga-Infante, Heidi, Maharaj, Lenushka, Hiley, Crispin T., Juliger, Simone, Joel, Simon P.

“…Purpose Selenium is a trace element that is fundamental to human health. Research has mainly focussed on its role in cancer prevention, but recent evidence…”
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Lesional-targeting of neuroprotection to the inflammatory penumbra in experimental multiple sclerosis by AL-IZKI, Sarah, PRYCE, Gareth, PERKINS, Victoria, GERRITSEN, Wouter H, UMMENTHUM, Kim, PEFEROEN-BAERT, Regina, VAN DER VALK, Paul, MONTOYA, Alexander, JOEL, Simon P, GARTHWAITE, John, GIOVANNONI, Gavin, SELWOOD, David L, HANKEY, Deborah J. R, BAKER, David, LIDSTER, Katie, VON KUTZLEBEN, Stephanie M, BROWNE, Lorcan, CLUTTERBUCK, Lisa, POSADA, Cristina, EDITH CHAN, A. W, AMOR, Sandra

“…Progressive multiple sclerosis is associated with metabolic failure of the axon and excitotoxicity that leads to chronic neurodegeneration. Global…”
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Methylseleninic acid antagonizes the cytotoxic effect of bortezomib in mantle cell lymphoma cell lines through modulation of Bcl-2 family proteins by Kassam, Shireen, Juliger, Simone, Jia, Li, Joel, Simon P.

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Chemosensitization of B-Cell Lymphomas by Methylseleninic Acid Involves Nuclear Factor-κB Inhibition and the Rapid Generation of Other Selenium Species by JÜLIGER, Simone, GOENAGA-INFANTE, Heidi, LISTER, T. Andrew, FITZGIBBON, Jude, JOEL, Simon P

“…Abstract Although recent reports suggest that selenium can modulate the activity of cytotoxic drugs, the mechanism underlying this activity remains unclear…”
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The histone deacetylase inhibitor UCL67022 has potent activity in multiple myeloma and non‐Hodgkin lymphoma pre‐clinical models by Maharaj, Lenushka, Marson, Charles M., Middleton, Brian J., Rioja, Alf S., Perry, Jackie, Oakervee, Heather, Cavenagh, Jamie, Joel, Simon P., Popat, Rakesh

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Morphine analgesia in cancer pain: role of the glucuronides by Penson, Richard T, Joel, Simon P, Gloyne, Anna, Clark, Simon, Slevin, Maurice L

“…Preclinical data and limited studies in humans have suggested that morphine-6-glucuronide (M6G) has analgesic activity and morphine-3-glucuronide (M3G),…”
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The bioavailability of morphine applied topically to cutaneous ulcers by Ribeiro, Maria D.C., Joel, Simon P., Zeppetella, Giovambattista

“…A number of studies have reported the analgesic effect of morphine when applied topically to painful skin ulcers. It has been suggested that morphine may exert…”
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Identification of genomic changes associated with cisplatin resistance in testicular germ cell tumor cell lines by Noel, Elodie E., Perry, Jackie, Chaplin, Tracy, Mao, Xueying, Cazier, Jean-Baptiste, Joel, Simon P., Oliver, R. Tim D., Young, Bryan D., Lu, Yong-Jie

“…Since the introduction of cisplatin into the clinic, the treatment of patients with a variety of solid tumors including testicular germ cell tumors, ovarian…”
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Randomized placebo-controlled trial of the activity of the morphine glucuronides by Penson, Richard T., Joel, Simon P., Bakhshi, Krishna, Clark, Simon J., Langford, Richard M., Slevin, Maurice L.

“…Background Morphine‐6‐glucuronide (M6G) is an active metabolite of morphine with potent analgesic activity. Morphine‐3‐glucuronide (M3G), the most prevalent…”
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Aromatic Sulfide Inhibitors of Histone Deacetylase Based on Arylsulfinyl-2,4-hexadienoic Acid Hydroxyamides by Marson, Charles M, Savy, Pascal, Rioja, Alphonso S, Mahadevan, Thevaki, Mikol, Catherine, Veerupillai, Arthi, Nsubuga, Eva, Chahwan, Angela, Joel, Simon P

“…The synthesis of a novel series of potent inhibitors of histone deacetylases is described, based on arylsulfinyl-2,4-hexadienoic acid hydroxyamides and their…”
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Structure–activity relationships of aryloxyalkanoic acid hydroxyamides as potent inhibitors of histone deacetylase by Marson, Charles M., Mahadevan, Thevaki, Dines, Jon, Sengmany, Stéphane, Morrell, James M., Alao, John P., Joel, Simon P., Vigushin, David M., Charles Coombes, R.

“…Aryl ether inhibitors of histone deacetylase are described. Syntheses of aryloxyalkanoic acid hydroxyamides are described, all of which are potent inhibitors…”
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The bioavailability and pharmacokinetics of subcutaneous, nebulized and oral morphine‐6‐glucuronide by Penson, Richard T., Joel, Simon P., Roberts, Michael, Gloyne, Anna, Beckwith, Stephen, Slevin, Maurice L.

“…Aims  Morphine‐6‐glucuronide (M6G), one of the active metabolites of morphine, has attracted considerable interest as a potent opioid analgesic with an…”
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