Search Results - "Joel, SP"

Bortezomib Therapy in Patients With Relapsed or Refractory Lymphoma: Potential Correlation of In Vitro Sensitivity and Tumor Necrosis Factor Alpha Response With Clinical Activity by STRAUSS, Sandra J, MAHARAJ, Lenushka, SCHENKEIN, David, BALKWILL, Frances, JOEL, Simon P, LISTER, T. Andrew, HOARE, Susan, JOHNSON, Peter W, RADFORD, John A, VINNECOMBE, Sarah, MILLARD, Lynda, ROHATINER, Ama, BORAL, Anthony, TREHU, Elizabeth

“…To determine the efficacy of bortezomib in patients with lymphoid malignancy, correlating clinical response with effect on plasma cytokines and in vitro…”
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Clinical response to morphine in cancer patients and genetic variation in candidate genes by Ross, J R, Rutter, D, Welsh, K, Joel, S P, Goller, K, Wells, A U, Du Bois, R, Riley, J

“…Morphine is the analgesic of choice for moderate to severe cancer pain; however, 10-30% of patients do not tolerate morphine. This study evaluated genetic…”
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The bioavailability of morphine applied topically to cutaneous ulcers by Ribeiro, Maria D.C., Joel, Simon P., Zeppetella, Giovambattista

“…A number of studies have reported the analgesic effect of morphine when applied topically to painful skin ulcers. It has been suggested that morphine may exert…”
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Randomized placebo-controlled trial of the activity of the morphine glucuronides by Penson, Richard T., Joel, Simon P., Bakhshi, Krishna, Clark, Simon J., Langford, Richard M., Slevin, Maurice L.

“…Background Morphine‐6‐glucuronide (M6G) is an active metabolite of morphine with potent analgesic activity. Morphine‐3‐glucuronide (M3G), the most prevalent…”
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The bioavailability and pharmacokinetics of subcutaneous, nebulized and oral morphine‐6‐glucuronide by Penson, Richard T., Joel, Simon P., Roberts, Michael, Gloyne, Anna, Beckwith, Stephen, Slevin, Maurice L.

“…Aims  Morphine‐6‐glucuronide (M6G), one of the active metabolites of morphine, has attracted considerable interest as a potent opioid analgesic with an…”
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Limited phase I study of morphine-3-glucuronide by Penson, R T, Joel, S P, Clark, S, Gloyne, A, Slevin, M L

“…The toxicity of morphine-3-glucuronide (M3G) has been investigated in an open, uncontrolled, single-blinded, single dose study over a limited range of doses…”
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Stability of morphine sulphate and diamorphine hydrochloride in intrasite gel by Zeppetella, Giovambattista, Joel, Simon P, Ribeiro, Maria D C

“…Several studies have reported that opioids applied topically to painful ulcers produce an analgesic effect. It is unknown whether these opioids (usually mixed…”
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Respiratory depression following morphine and morphine-6-glucuronide in normal subjects by THOMPSON, P. I, JOEL, S. P, JOHN, L, WEDZICHA, J. A, MACLEAN, M, SLEVIN, M. L

“…1. Morphine 6-glucuronide (M6G) is a metabolite of morphine with analgesic activity. A double-blind, randomised comparison of the effects of morphine and M6G…”
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Morphine intoxication in renal failure: the role of morphine-6-glucuronide by Osborne, R J, Joel, S P, Slevin, M L

“…Patients with impaired renal function may experience severe and prolonged respiratory depression when treated with morphine. This has been attributed to…”
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DNA damage is able to induce senescence in tumor cells in vitro and in vivo by TE POELE, Robert H, OKOROKOV, Andrei L, JARDINE, Lesley, CUMMINGS, Jeffrey, JOEL, Simon P

“…Often the use of cytotoxic drugs in cancer therapy results in stable disease rather than regression of the tumor, and this is typically seen as a failure of…”
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s-thalidomide has a greater effect on apoptosis than angiogenesis in a multiple myeloma cell line by Liu, Wai M, Strauss, Sandra J, Chaplin, Tracy, Shahin, Sipra, Propper, David J, Young, Bryan D, Joel, Simon P, Malpas, James S

“…s-Thalidomide has proven efficacy in multiple myeloma. Although it has both antiangiogenic and pro-apoptotic effects, its primary mode of therapeutic action…”
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A 'modified de Gramont' regimen of fluorouracil, alone and with oxaliplatin, for advanced colorectal cancer by CHEESEMAN, S. L, JOEL, S. P, CHESTER, J. D, WILSON, G, DENT, J. T, RICHARDS, F. J, SEYMOUR, M. T

“…The standard de Gramont (dG) regimen of fortnightly leucovorin, bolus fluorouracil and 22-h infusion of fluorouracil, d1+2, and the same regimen plus…”
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Histone acetylation-mediated regulation of genes in leukaemic cells by Chambers, A.E., Banerjee, S., Chaplin, T., Dunne, J., Debernardi, S., Joel, S.P., Young, B.D.

“…Histone deacetylase (HDAC) and histone acetyltransferase (HAT) functions are associated with various cancers, and the inhibition of HDAC has been found to…”
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Aromatic Sulfide Inhibitors of Histone Deacetylase Based on Arylsulfinyl-2,4-hexadienoic Acid Hydroxyamides by Marson, Charles M, Savy, Pascal, Rioja, Alphonso S, Mahadevan, Thevaki, Mikol, Catherine, Veerupillai, Arthi, Nsubuga, Eva, Chahwan, Angela, Joel, Simon P

“…The synthesis of a novel series of potent inhibitors of histone deacetylases is described, based on arylsulfinyl-2,4-hexadienoic acid hydroxyamides and their…”
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Phase I trial of intravesical Suramin in recurrent superficial transitional cell bladder carcinoma by ORD, J. J, STREETER, E, HARRIS, A. L, JONES, A, LE MONNIER, K, CRANSTON, D, CREW, J, JOEL, S. P, ROGERS, M. A, BANKS, R. E, ROBERTS, I. S. D

“…Suramin is an antitrypanosomal agent with antineoplastic activity, but with serious systemic side effects. We administered Suramin intravesically to determine…”
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The pharmacokinetics of morphine and morphine glucuronide metabolites after subcutaneous bolus injection and subcutaneous infusion of morphine by Stuart‐harris, R., Joel, S. P., McDonald, P., Currow, D., Slevin, M. L.

“…Aims  To investigate the pharmacokinetics of morphine, morphine‐6‐glucuronide (M6G) and morphine‐3‐glucuronide (M3G) in healthy volunteers after the…”
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Phase I and Pharmacokinetic Study of Intravenous Irinotecan Plus Oral Ciclosporin in Patients With Fluorouracil-Refractory Metastatic Colon Cancer by CHESTER, John D, JOEL, Simon P, CHEESEMAN, Susan L, HALL, Geoffrey D, BRAUN, Michael S, PERRY, Jackie, DAVIS, Theresa, BUTTON, Christopher J, SEYMOUR, Matthew T

“…Purpose: To assess the safety and toxicity profile of escalating doses of intravenous irinotecan, in combination with a fixed dose of oral ciclosporin (Cs) and…”
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Morphine and metabolite behavior after different routes of morphine administration: demonstration of the importance of the active metabolite morphine-6-glucuronide by Osborne, R, Joel, S, Trew, D, Slevin, M

“…The pharmacokinetic parameters of morphine, morphine-6-glucuronide, and morphine-3-glucuronide were studied after single-dose morphine administration by five…”
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Lack of pharmacokinetic interaction between 5-fluorouracil and oxaliplatin by Joel, Simon P., Papamichael, Dimitri, Richards, Fiona, Davis, Theresa, Aslanis, Vassili, Chatelut, Etienne, Locke, Kathryn, Slevin, Maurice L., Seymour, Matthew T.

“…Objective Our objective was to investigate the influence of oxaliplatin on the pharmacokinetics of 5‐fluorouracil (5FU) administered in a bolus plus infusional…”
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RNA synthesis block by 5, 6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) triggers p53-dependent apoptosis in human colon carcinoma cells by te Poele, R H, Okorokov, A L, Joel, S P

“…Most modern chemo- and radiotherapy treatments of human cancers use the DNA damage pathway, which induces a p53 response leading to either G1 arrest or…”
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