Search Results - "Jochum, W."

Patterns of progression on osimertinib in EGFR T790M positive NSCLC: A Swiss cohort study by Schmid, S., Klingbiel, D., Aeppli, S., Britschgi, C., Gautschi, O., Pless, M., Rothschild, S., Wannesson, L., Janthur, W., Foerbs, D., Demmer, I., Jochum, W., Früh, M.

“…•In patients with acquired osimertinib resistance rate of oligo-progression is high.•Main sites of PD were lung, bone lymph nodes, liver, pleura and…”
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Characterization of time-related changes after experimental bile duct ligation by Georgiev, P., Jochum, W., Heinrich, S., Jang, J. H., Nocito, A., Dahm, F., Clavien, P.-A.

“…Background: Although bile duct ligation (BDL) in mice is used to study cholestasis, a detailed description of this animal model is lacking. The aim of this…”
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Genomic characterisation of hormone receptor-positive breast cancer arising in very young women by Luen, S.J., Viale, G., Nik-Zainal, S., Savas, P., Kammler, R., Dell’Orto, P., Biasi, O., Degasperi, A., Brown, L.C., Láng, I., MacGrogan, G., Tondini, C., Bellet, M., Villa, F., Bernardo, A., Ciruelos, E., Karlsson, P., Neven, P., Climent, M., Müller, B., Jochum, W., Bonnefoi, H., Martino, S., Davidson, N.E., Geyer, C., Chia, S.K., Ingle, J.N., Coleman, R., Solbach, C., Thürlimann, B., Colleoni, M., Coates, A.S., Goldhirsch, A., Fleming, G.F., Francis, P.A., Speed, T.P., Regan, M.M., Loi, S.

“…Very young premenopausal women diagnosed with hormone receptor-positive, human epidermal growth factor receptor 2-negative (HR+HER2−) early breast cancer (EBC)…”
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PO-106: Prognostic significance of cyclin D1 and pRb expression in oropharyngeal carcinoma by Broglie, M.A, Plath, M.M, Stoeckli, S.J, Jochum, W

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High sex determining region Y-box 2 expression is a negative predictor of occult lymph node metastasis in early squamous cell carcinomas of the oral cavity by Züllig, L, Roessle, M, Weber, C, Graf, N, Haerle, S.K, Jochum, W, Stoeckli, S.J, Moch, H, Huber, G.F

“…Abstract Background The transcription factor sex determining region Y (SRY)-box 2 (SOX2) (3q26.3–q27) has been recently identified as a recurrently activated…”
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Individualized treatment approaches for Langerhans cell histiocytosis by Roider, E., Signer, C., Fehrenbacher, B., Metzler, G., Schaller, M., Kamarachev, J., Kerl, K., Balabanov, S., Jochum, W., Hoetzenecker, W., Cozzio, A., French, L.E., Dummer, R., Guenova, E.

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How to read a next-generation sequencing report—what oncologists need to know by Schmid, S., Jochum, W., Padberg, B., Demmer, I., Mertz, K.D., Joerger, M., Britschgi, C., Matter, M.S., Rothschild, S.I., Omlin, A.

“…Next-generation sequencing (NGS) of tumor cell-derived DNA/RNA to screen for targetable genomic alterations is now widely available and has become part of…”
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Epidermal growth factor receptor and anaplastic lymphoma kinase testing and mutation prevalence in patients with advanced non‐small cell lung cancer in Switzerland: A comprehensive evaluation of real world practices by Ess, S.M., Herrmann, C., Frick, H., Krapf, M., Cerny, T., Jochum, W., Früh, M.

“…In order to improve outcomes, identification of the epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) genes has become crucial in…”
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Patterns of recurrence to Osimertinib in T790m positive NSCLC: A Swiss cohort study by Schmid, S., Klingbiel, D., Aeppli, S., Britschgi, C., Gautschi, O., Pless, M., Rothschild, S.I., Wannesson De Nicola, L., Janthur, W.-D., Foerbs, D., Demmer, I., Jochum, W., Früh, M.

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Brain metastases in gastro-oesophageal adenocarcinoma: insights into the role of the human epidermal growth factor receptor 2 (HER2) by Feilchenfeldt, J, Varga, Z, Siano, M, Grabsch, H I, Held, U, Schuknecht, B, Trip, A, Hamaguchi, T, Gut, P, Balague, O, Khanfir, K, Diebold, J, Jochum, W, Shoji, H, Kushima, R, Wagner, D, Shimada, Y, Cats, A, Knuth, A, Moch, H, Aebi, S, Hofer, S

“…Background: Gastro-oesophageal adenocarcinomas rarely metastasize to the central nervous system (CNS). The role of the human epidermal growth factor receptor 2…”
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Genomic profiling of late‐onset basal cell carcinomas from two brothers with nevoid basal cell carcinoma syndrome by Hasan Ali, O., Yurchenko, A.A., Pavlova, O., Sartori, A., Bomze, D., Higgins, R., Ring, S.S., Hartmann, F., Bühler, D., Fritzsche, F.R., Jochum, W., Navarini, A.A., Kim, A., French, L.E., Dermitzakis, E., Christiano, A.M., Hohl, D., Bickers, D.R., Nikolaev, S.I., Flatz, L.

“…Background Nevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominant genetic disorder. It is commonly caused by mutations in PTCH1 and chiefly…”
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P1053: ALBUMIN AND C‐REACTIVE PROTEIN PROVIDE PROGNOSTIC INFORMATION INDEPENDENTLY FROM MIPSS70 IN OVERT MYELOFIBROSIS. A RETROSPECTIVE STUDY by Messerich, N.‐M., Volken, T., Cogliatti, S., Lehmann, T., Holbro, A., Demmer, I., Benz, R., Jochum, W., Silzle, T.

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Neoadjuvant treatment does not influence PD-L1 expression in stage III non-small-cell lung cancer: a retrospective analysis of tumor samples from the trials SAKK 16/96, 16/00, 16/01, and 16/14 by König, D., Savic Prince, S., Hayoz, S., Zens, P., Berezowska, S., Jochum, W., Stauffer, E., Braunersreuther, V., Trachsel, B., Thierstein, S., Mark, M., Schmid, S., Curioni-Fontecedro, A., Addeo, A., Opitz, I., Guckenberger, M., Früh, M., Betticher, D.C., Ris, H.-B., Stupp, R., Rothschild, S.I., Bubendorf, L., Pless, M.

“…The inclusion of immune checkpoint inhibitors (ICIs) in the treatment of operable stage III non-small-cell lung cancer is becoming a new standard. Programmed…”
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PB2060: THE MDS‐SPECIFIC COMORBIDITY INDEX (MDS‐CI) PREDICTS SURVIVAL INDEPENDENTLY FROM DIPSS AND MIPSS70 IN PATIENTS WITH OVERT MYELOFIBROSIS NOT ELIGIBLE FOR ALLOGENEIC STEM CELL TRANSPLANTATION by Koster, K.‐L., Messerich, N.‐M., Volken, T., Cogliatti, S., Lehmann, T., Holbro, A., Benz, R., Graf, L., Demmer, I., Jochum, W., Silzle, T.

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Brain metastases in gastro-oesophageal adenocarcinoma: insights into the role of the human epidermal growth factor receptor 2 (HER2) by Feilchenfeldt, J, Varga, Z, Siano, M, Grabsch, H I, Held, U, Schuknecht, B, Trip, A, Hamaguchi, T, Gut, P, Balague, O, Khanfir, K, Diebold, J, Jochum, W, Shoji, H, Kushima, R, Wagner, D, Shimada, Y, Cats, A, Knuth, A, Moch, H, Aebi, S, Hofer, S

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Placental vascularisation requires the AP-1 component fra1 by Schreiber, M, Wang, Z Q, Jochum, W, Fetka, I, Elliott, C, Wagner, E F

“…Fra1 is an immediate-early gene encoding a member of the AP-1 transcription factor family, which has diverse roles in development and oncogenesis. To determine…”
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Analysis of oncogenic AKT1 p.E17K mutation in carcinomas of the biliary tract and liver by Riener, M-O, Bawohl, M, Clavien, P-A, Jochum, W

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Mitochondrially targeted ceramide LCL-30 inhibits colorectal cancer in mice by Dahm, F, Bielawska, A, Nocito, A, Georgiev, P, Szulc, Z M, Bielawski, J, Jochum, W, Dindo, D, Hannun, Y A, Clavien, P-A

“…The sphingolipid ceramide is intimately involved in the growth, differentiation, senescence, and death of normal and cancerous cells. Mitochondria are…”
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P137 Triple negative breast cancer in population of eastern Switzerland: Clinical features and outcome by Ess, S, Öhlschlagel, C, Thürlimann, B, Jochum, W

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P321 Metastatic triple-negative breast cancer: A population based study by Ess, S, Jochum, W, Öhlschlägel, C, Thürlimann, B

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