Prevalence of familial pancreatic cancer in Germany

Based on several case‐control studies, it has been estimated that familial aggregation and genetic susceptibility play a role in up to 10% of patients with pancreatic cancer, although conclusive epidemiologic data are still lacking. Therefore, we evaluated the prevalence of familial pancreatic cance...

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Published in:	International journal of cancer Vol. 110; no. 6; pp. 902 - 906
Main Authors:	Bartsch, Detlef K., Kress, Ralf, Sina‐Frey, Mercedes, Grützmann, Robert, Gerdes, Berthold, Pilarsky, Christian, Heise, Joachim W., Schulte, Klaus‐Martin, Colombo‐Benkmann, Mario, Schleicher, Cristina, Witzigmann, Helmut, Pridöhl, Olaf, Ghadimi, Michael B., Horstmann, Olaf, von Bernstorff, Wolfgang, Jochimsen, Lisa, Schmidt, Jan, Eisold, Sven, Estévéz‐Schwarz, Lope, Hahn, Stephan A., Schulmann, Karsten, Böck, Wolfgang, Gress, Thomas M., Zügel, Nikolaus, Breitschaft, Karl, Prenzel, Klaus, Messmann, Helmut, Endlicher, Esther, Schneider, Margarete, Ziegler, Andreas, Schmiegel, Wolff, Schäfer, Helmut, Rothmund, Matthias, Rieder, Harald
Format:	Journal Article
Language:	English
Published:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 20-07-2004 Wiley-Liss
Subjects:	Adult Aged Biological and medical sciences epidemiology familial pancreatic cancer Family Female Gastroenterology. Liver. Pancreas. Abdomen Genetic Predisposition to Disease - genetics Germany - epidemiology Humans Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical Records Medical sciences Middle Aged Odds Ratio Pancreatic Neoplasms - epidemiology Pancreatic Neoplasms - genetics Pancreatic Neoplasms - pathology Prevalence Retrospective Studies Tumors Europe Germany Human Prospective Cancerology Prevalence Pancreas cancer Digestive diseases Familial cancer Malignant tumor Epidemiology Public health Pancreatic disease
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Summary:	Based on several case‐control studies, it has been estimated that familial aggregation and genetic susceptibility play a role in up to 10% of patients with pancreatic cancer, although conclusive epidemiologic data are still lacking. Therefore, we evaluated the prevalence of familial pancreatic cancer and differences to its sporadic form in a prospective multicenter trial. A total of 479 consecutive patients with newly diagnosed, histologically confirmed adenocarcinoma of the pancreas were prospectively evaluated regarding medical and family history, treatment and pathology of the tumour. A family history for pancreatic cancer was confirmed whenever possible by reviewing the tumour specimens and medical reports. Statistical analysis was performed by calculating odds ratios, regression analysis with a logit‐model and the Kaplan‐Meier method. Twenty‐three of 479 (prevalence 4.8%, 95% CI 3.1–7.1) patients reported at least 1 first‐degree relative with pancreatic cancer. The familial aggregation could be confirmed by histology in 5 of 23 patients (1.1%, 95% CI 0.3–2.4), by medical records in 9 of 23 patients (1.9%, 95% CI 0.9–3.5) and by standardized interviews of first‐degree relatives in 17 of 23 patients (3.5%, 95% CI 2.1–5.6), respectively. There were no statistical significant differences between familial and sporadic pancreatic cancer cases regarding sex ratio, age of onset, presence of diabetes mellitus and pancreatitis, tumour histology and stage, prognosis after palliative or curative treatment as well as associated tumours in index patients and families, respectively. The prevalence of familial pancreatic cancer in Germany is at most 3.5% (range 1.1–3.5%) depending on the mode of confirmation of the pancreatic carcinoma in relatives. This prevalence is lower than so far postulated in the literature. There were no significant clinical differences between the familial and sporadic form of pancreatic cancer. © 2004 Wiley‐Liss, Inc.
Bibliography:	Fax: +49‐6421‐2868995 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0020-7136 1097-0215
DOI:	10.1002/ijc.20210