Search Results - "Jochemsen, A G"

Mdm2 induces mono-ubiquitination of FOXO4 by Brenkman, Arjan B, de Keizer, Peter L J, van den Broek, Niels J F, Jochemsen, A G, Burgering, Boudewijn M Th

“…The Forkhead box O (FOXO) class of transcription factors are involved in the regulation of several cellular responses including cell cycle progression and…”
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Breast cancer dormancy is associated with a 4NG1 state and not senescence by Prunier, Chloé, Alay, Ania, van Dijk, Michiel, Ammerlaan, Kelly L., van Gelderen, Sharon, Marvin, Dieuwke L., Teunisse, Amina, Slieker, Roderick C., Szuhai, Karoly, Jochemsen, A. G., Solé, Xavier, ten Dijke, Peter, Ritsma, Laila

“…Reactivation of dormant cancer cells can lead to cancer relapse, metastasis, and patient death. Dormancy is a nonproliferative state and is linked to late…”
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Role of Mdm4 in drug sensitivity of breast cancer cells by Lam, S, Lodder, K, Teunisse, A F A S, Rabelink, M J W E, Schutte, M, Jochemsen, A G

“…The p53 tumor suppressor protein is frequently mutated in human tumors. It is thought that the p53 pathway is indirectly impaired in the remaining tumors, for…”
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Abrogation of Wip1 expression by RITA-activated p53 potentiates apoptosis induction via activation of ATM and inhibition of HdmX by Spinnler, C, Hedström, E, Li, H, de Lange, J, Nikulenkov, F, Teunisse, A F A S, Verlaan-de Vries, M, Grinkevich, V, Jochemsen, A G, Selivanova, G

“…Inactivation of the p53 tumour suppressor, either by mutation or by overexpression of its inhibitors Hdm2 and HdmX is the most frequent event in cancer…”
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The large E1B protein together with the E4orf6 protein target p53 for active degradation in adenovirus infected cells by STEEGENGA, W. T, RITECO, N, JOCHEMSEN, A. G, FALLAUX, F. J, BOS, J. L

“…It has recently been shown that an adenovirus mutant lacking expression of the large E1B protein (deltaE1B) selectively replicates in p53 deficient cells…”
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MDMX: a novel p53‐binding protein with some functional properties of MDM2 by Shvarts, A., Steegenga, W. T., Riteco, N., Laar, T., Dekker, P., Bazuine, M., Ham, R. C., Houven van Oordt, W., Hateboer, G., Eb, A. J., Jochemsen, A. G.

“…Here we report the isolation of a cDNA encoding a new p53‐associating protein. This new protein has been called MDMX on the basis of its structural similarity…”
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Aberrant expression of HDMX proteins in tumor cells correlates with wild-type p53 by RAMOS, Yolande F. M, STAD, Robert, ATTEMA, Joline, PELTENBURG, Lucy T. C, VAN DER EB, Alex J, JOCHEMSEN, Aart G

“…It has been shown that the Hdmx gene is amplified in a subset of gliomas, but thus far, no data are available on HDMX protein expression in tumor cells. We now…”
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RNF4 is required for DNA double-strand break repair in vivo by Vyas, R, Kumar, R, Clermont, F, Helfricht, A, Kalev, P, Sotiropoulou, P, Hendriks, I A, Radaelli, E, Hochepied, T, Blanpain, C, Sablina, A, van Attikum, H, Olsen, J V, Jochemsen, A G, Vertegaal, A C O, Marine, J-C

“…Unrepaired DNA double-strand breaks (DSBs) cause genetic instability that leads to malignant transformation or cell death. Cells respond to DSBs with the…”
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Hdmx Stabilizes Mdm2 and p53 by Stad, R, Ramos, Y F, Little, N, Grivell, S, Attema, J, van Der Eb, A J, Jochemsen, A G

“…The Mdm2 protein is a key regulator of p53 activity and stability. Upon binding, Mdm2 inhibits the transcription regulatory activity of p53 and promotes its…”
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Hdmx and Mdm2 can repress transcription activation by p53 but not by p63 by LITTLE, Natalie A, JOCHEMSEN, Aart G

“…The p53 protein is involved in cell cycle arrest and apoptosis. To ensure that cells under non-stressed conditions are able to grow, p53 sets up a negative…”
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Comparative study of the p53-mdm2 and p53-MDMX interfaces by BÖTTGER, V, BÖTTGER, A, GARCIA-ECHEVERRIA, C, RAMOS, Y. F. M, VAN DER EB, A. J, JOCHEMSEN, A. G, LANE, D. P

“…Mdm2 and MDMX are two structurally related p53-binding proteins which show the highest level of sequence similarity in the N-terminal p53-binding domains…”
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Isolation and Identification of the Human Homolog of a New p53-Binding Protein, Mdmx by Shvarts, Avi, Bazuine, Merlijn, Dekker, Patrick, Ramos, Yolande F.M., Steegenga, Wilma T., Merckx, Gerard, van Ham, Reinier C.A., van der Houven van Oordt, Willemien, van der Eb, Alex J., Jochemsen, A.G.

“…We recently reported the identification of a mouse cDNA encoding a new p53-associating protein that we called Mdmx because of its structural similarity to…”
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Mice engineered for an obligatory Mdm4 exon skipping express higher levels of the Mdm4-S isoform but exhibit increased p53 activity by Bardot, B, Bouarich-Bourimi, R, Leemput, J, Lejour, V, Hamon, A, Plancke, L, Jochemsen, A G, Simeonova, I, Fang, M, Toledo, F

“…Mdm4, a protein related to the ubiquitin-ligase Mdm2, is an essential inhibitor of tumor suppressor protein p53. In both human and mouse cells, the Mdm4 gene…”
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Synergistic growth inhibition based on small-molecule p53 activation as treatment for intraocular melanoma by de Lange, J, Ly, L V, Lodder, K, Verlaan-de Vries, M, Teunisse, A F A S, Jager, M J, Jochemsen, A G

“…The prognosis of patients with uveal melanoma is poor. Because of the limited efficacy of current treatments, new therapeutic strategies need to be developed…”
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Multiple neurotoxic stresses converge on MDMX proteolysis to cause neuronal apoptosis by Benosman, S, Gross, I, Clarke, N, Jochemsen, A G, Okamoto, K, Loeffler, J-P, Gaiddon, C

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Novel splice variants of CXCR4 identified by transcriptome sequencing by Sand, L.G.L., Jochemsen, A.G., Beletkaia, E., Schmidt, T., Hogendoorn, P.C.W., Szuhai, K.

“…Chemokine receptor CXCR4 is involved in tumor growth, angiogenesis and metastasis. Its function is regulated in many ways and one of them is alternative…”
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Chk2 mediates RITA-induced apoptosis by de Lange, J, Verlaan-de Vries, M, Teunisse, A F A S, Jochemsen, A G

“…Reactivation of the p53 tumor-suppressor protein by small molecules like Nutlin-3 and RITA (reactivation of p53 and induction of tumor cell apoptosis) is a…”
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Distinct p53‐independent apoptotic cell death signalling pathways in testicular germ cell tumour cell lines by Burger, Herman, Nooter, Kees, Boersma, Antonius W.M., van Wingerden, Kyra E., Looijenga, Leendert H.J., Jochemsen, Aart G., Stoter, Gerrit

“…The induction of apoptosis by diverse apoptotic stimuli was studied in a panel of 6 testicular germ cell tumour(TGCT) cell lines with defined p53 status…”
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Mdmx as an essential regulator of p53 activity by Marine, Jean-Christophe, Jochemsen, Aart G.

“…The murine double minute 2 (Mdm2) is a critical negative regulator of the p53 tumor suppressor. Almost 10 years ago, a search for new p53-interactors revealed…”
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How Phosphorylation Regulates the Activity of p53 by Steegenga, Wilma T., van der Eb, Alex J., Jochemsen, A.G.

“…P53 is of key importance for the protection of an organism against carcinogenesis. P53 performs this function by the regulation of several cellular processes,…”
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