The antimanic-like effect of phenytoin and carbamazepine on methylphenidate-induced hyperlocomotion: role of voltage-gated sodium channels

The objective of this study was to verify whether phenytoin modifies methylphenidate‐induced hyperlocomotion, an animal model for screening antimanic‐like drugs, and also evaluate the effect of veratrine, a voltage‐gated sodium channel opener, pretreatment on the effect of phenytoin in this model. C...

Full description

Saved in:

Bibliographic Details
Published in:	Fundamental & clinical pharmacology Vol. 27; no. 6; pp. 650 - 655
Main Authors:	Tonelli, Denise A.G., Pereira, Marcela, Siba, Isadora P., Martynhak, Bruno J., Correia, Diego, Casarotto, Plínio C., Biojone, Caroline, Guimarães, Francisco S., Joca, Samia L.R., Andreatini, Roberto
Format:	Journal Article
Language:	English
Published:	Oxford Blackwell Publishing Ltd 01-12-2013 Blackwell
Subjects:	Adult and adolescent clinical studies animal model Animals anticonvulsant Antimanic Agents - administration & dosage Antimanic Agents - pharmacology Biological and medical sciences bipolar Bipolar Disorder - drug therapy Bipolar Disorder - physiopathology Carbamazepine - administration & dosage Carbamazepine - pharmacology Disease Models, Animal Dose-Response Relationship, Drug Male Mania Medical sciences methylphenidate Methylphenidate - pharmacology Mice Mood disorders Motor Activity - drug effects Pharmacology. Drug treatments Phenytoin - administration & dosage Phenytoin - pharmacology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry veratrine Veratrine - pharmacology Voltage-Gated Sodium Channels - drug effects Voltage-Gated Sodium Channels - metabolism Mood disorder Animal model veratrine CNS stimulant Psychotropic Anticonvulsant Ionic channel Tricyclic compound Carbamazepine Alkaloid Sodium Mood stabilizer Piperidine derivatives Mania Carboxamide bipolar Gating Dibenzazepine derivatives Methylphenidate Phenytoin methylphenidate animal model anticonvulsant mania
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The objective of this study was to verify whether phenytoin modifies methylphenidate‐induced hyperlocomotion, an animal model for screening antimanic‐like drugs, and also evaluate the effect of veratrine, a voltage‐gated sodium channel opener, pretreatment on the effect of phenytoin in this model. Carbamazepine was used as a positive control. Methylphenidate (5 mg/kg, s.c.) increased open‐field locomotion, and phenytoin (5–10 mg/kg, i.p.) and carbamazepine (20 mg/kg, i.p.) blocked this effect. Veratrine (0.4 mg/kg, s.c.) pretreatment reversed the effects of phenytoin (10 mg/kg, i.p.) and carbamazepine (20 mg/kg, i.p.). Phenytoin (1–50 mg/kg, i.p.) and carbamazepine (10–20 mg/kg i.p.) alone did not change spontaneous locomotor activity. These results indicate that voltage‐gated sodium channels play an important role in antimanic‐like effects of phenytoin and carbamazepine on psychostimulant‐induced hyperlocomotion model.
Bibliography:	ark:/67375/WNG-SPJBJJF5-5 istex:722A5A2E133F373C43DA12AED466F86A5F663BA8 ArticleID:FCP12022 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0767-3981 1472-8206
DOI:	10.1111/fcp.12022