Search Results - "Jobe, A H"

Chorioamnionitis induces enteric nervous system injury: effects of timing and inflammation in the ovine fetus by Heymans, C, de Lange, I H, Lenaerts, K, Kessels, L C G A, Hadfoune, M, Rademakers, G, Melotte, V, Boesmans, W, Kramer, B W, Jobe, A H, Saito, M, Kemp, M W, van Gemert, W G, Wolfs, T G A M

“…Chorioamnionitis, inflammation of the chorion and amnion, which often results from intrauterine infection, is associated with premature birth and contributes…”
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Contribution of inflammation to lung injury and development by Kallapur, S G, Jobe, A H

“…Inflammation interferes with lung development in model systems and is present chronically in the lungs of preterm infants who develop bronchopulmonary…”
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Clinical interventions to reduce stillbirths in sub‐Saharan Africa: a mathematical model to estimate the potential reduction of stillbirths associated with specific obstetric conditions by Goldenberg, RL, Griffin, JB, Kamath‐Rayne, BD, Harrison, M, Rouse, DJ, Moran, K, Hepler, B, Jobe, AH, McClure, EM

“…Objective Stillbirths are among the most common adverse pregnancy outcomes, with 98% occurring in low‐income countries. More than one‐third occur in…”
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Mechanisms initiating lung injury in the preterm by Jobe, Alan H., Ikegami, Machiko

“…Bronchopulmonary dysplasia (BPD)/chronic lung disease occurs primarily in very low birth weight infants (VLBW) often without antecedent severe respiratory…”
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Lung development and function in preterm infants in the surfactant treatment era by Jobe, A H, Ikegami, M

“…Mortality of infants of < 1-kg birth weight has decreased because of surfactant treatments, antenatal glucocorticoid treatments, and new ventilation…”
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The clinical use of corticosteroids in pregnancy by Kemp, M W, Newnham, J P, Challis, J G, Jobe, A H, Stock, S J

“…The use of antenatal steroid therapy is common in pregnancy. In early pregnancy, steroids may be used in women for the treatment of recurrent miscarriage or…”
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Fetal Versus Maternal and Gestational Age Effects of Repetitive Antenatal Glucocorticoids by Jobe, Alan H, Newnham, John, Willet, Karen, Sly, Peter, Ikegami, Machiko

“…Although single courses of antenatal glucocorticoids decrease respiratory distress syndrome and mortality, repetitive courses of antenatal glucocorticoids are…”
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Single and repetitive maternal glucocorticoid exposures reduce fetal growth in sheep by Jobe, Alan H., Wada, Norihisa, Berry, Lynne M., Ikegami, Machiko, Ervin, M.Gore

“…OBJECTIVE: We evaluated the effects of single or three repeated doses of maternal betamethasone on fetal growth at preterm and term delivery in sheep. STUDY…”
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Bronchopulmonary dysplasia by JOBE, Alan H, BANCALARI, Eduardo

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Endotoxin-induced lung maturation in preterm lambs is not mediated by cortisol by JOBE, Alan H, NEWNHAM, John P, WILLET, Karen E, MOSS, Timothy J, ERVIN, M. Gore, PADBURY, James F, SLY, Peter, IKEGAMI, Machiko

“…Antenatal exposure to glucocorticoids, amnionitis, intraamniotic interleukin (IL)-1alpha, or endotoxin can improve postnatal lung function after preterm…”
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Tidal volume effects on surfactant treatment responses with the initiation of ventilation in preterm lambs by Wada, Kazuko, Jobe, Alan H, Ikegami, Machiko

“…Kazuko Wada, Alan H. Jobe, and Machiko Ikegami Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California 90502 Received 7 March 1997; accepted…”
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What is BPD in 2012 and what will BPD become? by Jobe, A.H

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Repetitive prenatal glucocorticoids improve lung function and decrease growth in preterm lambs by IKEGAMI, M, JOBE, A. H, NEWNHAM, J, POLK, D. H, WILLET, K. E, SLY, P

“…We evaluated the effects of multiple fetal exposures to glucocorticoids on postnatal lung function and growth. Ewes were randomized to receive 1 to 4 doses of…”
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Positive end-expiratory pressure preserves surfactant function in preterm lambs by MICHNA, J, JOBE, A. H, IKEGAMI, M

“…Ventilation style influences lung injury and the amount of large-aggregate biophysically active surfactant in adult lungs. We asked how positive end-expiratory…”
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Surfactant metabolism in transgenic mice after granulocyte macrophage-colony stimulating factor ablation by Ikegami, M, Ueda, T, Hull, W, Whitsett, J A, Mulligan, R C, Dranoff, G, Jobe, A H

“…Mice made granulocyte macrophage-colony stimulating factor (GM-CSF)-deficient by homologous recombination maintain normal steady-state hematopoiesis but have…”
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Surfactant metabolism in surfactant protein A-deficient mice by Ikegami, M, Korfhagen, T R, Bruno, M D, Whitsett, J A, Jobe, A H

“…In the present study we asked if surfactant metabolism was altered in surfactant protein (SP) A-deficient mice in vivo. Although previous studies in vitro…”
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Altered Surfactant Function and Structure in SP-A Gene Targeted Mice by Korfhagen, Thomas R., Bruno, Michael D., Ross, Gary F., Huelsman, Karen M., Ikegami, Machiko, Jobe, Alan H., Wert, Susan E., Stripp, Barry R., Morris, Randal E., Glasser, Stephan W., Bachurski, Cindy J., Iwamoto, Harriet S., Whitsett, Jeffrey A.

“…The surfactant protein A (SP-A) gene was disrupted by homologous recombination in embryonic stem cells that were used to generate homozygous SP-A-deficient…”
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Effects of antenatal endotoxin and glucocorticoids on the lungs of preterm lambs by Jobe, Alan H., Newnham, John P., Willet, Karen E., Sly, Peter, Ervin, M.Gore, Bachurski, Cindy, Possmayer, Fred, Hallman, Mikko, Ikegami, Machiko

“…Objective: We hypothesized that the proinflammatory response to intra-amniotic endotoxin would induce lung maturation in preterm lambs. Study Design: Ewes were…”
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Preterm newborn lamb renal and cardiovascular responses after fetal or maternal antenatal betamethasone by Berry, L M, Polk, D H, Ikegami, M, Jobe, A H, Padbury, J F, Ervin, M G

“…The optimal dose, route of administration, and treatment-to-delivery interval necessary to induce beneficial extrapulmonary effects of glucocorticoids are not…”
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Lung morphometry after repetitive antenatal glucocorticoid treatment in preterm sheep by WILLET, Karen E, JOBE, Alan H, IKEGAMI, Machiko, KOVAR, Jana, SLY, Peter D

“…Antenatal glucocorticoids are thought to be less effective when delivery occurs more than 7 d after initiation of treatment; therefore, repeat courses are…”
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