Search Results - "Job, Laura"

Time-course and degradation rate of membrane scaffold protein (MSP1D1) during recombinant production by Faas, Ramona, Kiefer, Dirk, Job, Laura, Pohle, Annelie, Moß, Karin, Henkel, Marius, Hausmann, Rudolf

“…•Relevant efficiency parameters, productivities and production rates for recombinant MSP1D1 are presented for the first time.•Time-course of MSP1D1…”
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Breast cancer survival in Brazil: How much health care access impact on cancer outcomes? by Caleffi, Maira, Crivelatti, Isabel, Burchardt, Norah A., Ribeiro, Rodrigo A., Acevedo, Yulieth, Job, Laura Gianotti, Nonnemacher, Nouara, Rosa, Daniela Dornelles

“…Breast cancer has a high incidence and increasing mortality in Southern Brazil. The present study evaluated clinical and sociodemographic characteristics, and…”
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New in vitro system to predict chemotherapeutic efficacy of drug combinations in fresh tumor samples by Kischkel, Frank Christian, Eich, Julia, Meyer, Carina I, Weidemüller, Paula, Krapfl, Jens, Yassin-Kelepir, Rauaa, Job, Laura, Fraefel, Marius, Braicu, Ioana, Kopp-Schneider, Annette, Sehouli, Jalid, De Wilde, Rudy Leon

“…To find the best individual chemotherapy for cancer patients, the efficacy of different chemotherapeutic drugs can be predicted by pretesting tumor samples via…”
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Inhibition of an organophosphate-detoxifying bacterial phosphotriesterase by albumin and plasma thiol components by Köhler, Anja, Job, Laura, Worek, Franz, Skerra, Arne

“…•The phosphotriesterase from Brevundimonas diminuta can hydrolyse OP nerve agents.•BdPTE has shown less efficient breakdown of an OP in an animal model than in…”
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A catalytic bioscavenger with improved stability and reduced susceptibility to oxidation for treatment of acute poisoning with neurotoxic organophosphorus compounds by Job, Laura, Köhler, Anja, Escher, Benjamin, Worek, Franz, Skerra, Arne

“…•The phosphotriesterase from Brevundimonas diminuta can hydrolyze organophosphates.•Engineered BdPTE offers a catalytic bioscavenger of nerve agents and…”
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Structural and Functional Analysis of a Highly Active Designed Phosphotriesterase for the Detoxification of Organophosphate Nerve Agents Reveals an Unpredicted Conformation of the Active Site Loop by Job, Laura, Köhler, Anja, Eichinger, Andreas, Testanera, Mauricio, Escher, Benjamin, Worek, Franz, Skerra, Arne

“…Neurotoxic organophosphorus compounds (OPs) pose a severe threat if misused in military conflicts or by terrorists. Administration of a hydrolytic enzyme that…”
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Translating the Concept of Bispecific Antibodies to Engineering Heterodimeric Phosphotriesterases with Broad Organophosphate Substrate Recognition by Escher, Benjamin, Köhler, Anja, Job, Laura, Worek, Franz, Skerra, Arne

“…We have adopted the concept of bispecific antibodies, which can simultaneously block or cross-link two different biomolecular targets, to create bispecific…”
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Engineering of a phosphotriesterase with improved stability and enhanced activity for detoxification of the pesticide metabolite malaoxon by Job, Laura, Köhler, Anja, Testanera, Mauricio, Escher, Benjamin, Worek, Franz, Skerra, Arne

“…Abstract Organophosphorus (OP) pesticides are still widely applied but pose a severe toxicological threat if misused. For in vivo detoxification, the…”
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Catalytic activity and stereoselectivity of engineered phosphotriesterases towards structurally different nerve agents in vitro by Köhler, Anja, Escher, Benjamin, Job, Laura, Koller, Marianne, Thiermann, Horst, Skerra, Arne, Worek, Franz

“…Highly toxic organophosphorus nerve agents, especially the extremely stable and persistent V-type agents such as VX, still pose a threat to the human…”
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Post-VX exposure treatment of rats with engineered phosphotriesterases by Stigler, Lisa, Köhler, Anja, Koller, Marianne, Job, Laura, Escher, Benjamin, Potschka, Heidrun, Thiermann, Horst, Skerra, Arne, Worek, Franz, Wille, Timo

“…The biologically stable and highly toxic organophosphorus nerve agent (OP) VX poses a major health threat. Standard medical therapy, consisting of reactivators…”
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