Search Results - "Joannides, E T"

Structure-activity relationships of quinolone agents against mycobacteria: effect of structural modifications at the 8 position by RENAU, T. E, GAGE, J. W, REYNOLDS, R. C, DEVER, J. A, ROLAND, G. E, JOANNIDES, E. T, SHAPIRO, M. A, SANCHEZ, J. P, GRACHECK, S. J, DOMAGALA, J. M, JACOBS, M. R

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In vivo therapeutic efficacies of PD 138312 and PD 140248, two novel fluoronaphthyridines with outstanding gram-positive potency by SHAPIRO, M. A, DEVER, J. A, JOANNIDES, E. T, SESNIE, J. C, VANDERROEST, S. R

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New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk by Sanchez, J. P, Bridges, A. J, Bucsh, R, Domagala, J. M, Gogliotti, R. D, Hagen, S. E, Heifetz, C. L, Joannides, E. T, Sesnie, J. C

“…A series of 8-(trifluoromethyl)-substituted quinolones has been prepared and evaluated for in vitro and in vivo antibacterial activity, and phototolerance in a…”
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In vitro evaluation of cefdinir (FK482), a new oral cephalosporin with enhanced antistaphylococcal activity and beta-lactamase stability by Cohen, M A, Joannides, E T, Roland, G E, Meservey, M A, Huband, M D, Shapiro, M A, Sesnie, J C, Heifetz, C L

“…Cefdinir (FK482), a new oral cephalosporin with enhanced beta-lactamase stability, was tested by microbroth dilution against respiratory, urogenital, and skin…”
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A novel rapid throughput phototolerance screen in mice by Shapiro, Martin A., Sesnie, Josephine C., Joannides, E.Themis, Malta, Thomas E., Dever, Julie A., Heifetz, Carl L.

“…A relatively simple, rapid throughput phototolerance screen in small animals would be very useful in early drug development. It could prioritize or select…”
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3-Aminoquinazolinediones as a New Class of Antibacterial Agents Demonstrating Excellent Antibacterial Activity Against Wild-Type and Multidrug Resistant Organisms by Ellsworth, EL, Tran, T P, Showalter, HDH, Sanchez, J P, Watson, B M, Stier, MA, Domagala, J M, Gracheck, S J, Joannides, E T, Shapiro, MA, Dunham, SA, Hanna, D L, Huband, MD, Gage, J W

“…The 3-aminoquinzolinediones represent a new series of antibacterial agents structurally related to the fluoroquinolones. They are inhibitors of bacterial…”
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Synthesis and structural–activity relationships of 3-hydroxyquinazoline-2,4-dione antibacterial agents by Tran, Tuan P., Ellsworth, Edmund L., Stier, Michael A., Domagala, John M., Hollis Showalter, H.D., Gracheck, Stephen J., Shapiro, Martin A., Joannides, Themis E., Singh, Rajeshwar

“…The synthesis and SAR of the 3-hydroxyquinazoline diones, a novel class of bacterial topoisomerase inhibitors, is reported. A series of…”
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