Search Results - "Joan Carboni"

Insulin-Mediated Acceleration of Breast Cancer Development and Progression in a Nonobese Model of Type 2 Diabetes by NOVOSYADLYY, Ruslan, LANN, Danielle E, KURSHAN, Naamit, MEJIA, Wilson, SANTOPIETRO, Stefania, YAKAR, Shoshana, WOOD, Teresa L, LEROITH, Derek, VIJAYAKUMAR, Archana, ROWZEE, Anne, LAZZARINO, Deborah A, FIERZ, Yvonne, CARBONI, Joan M, GOTTARDIS, Marco M, PENNISI, Patricia A, MOLINOLO, Alfredo A

“…Epidemiologic studies suggest that type 2 diabetes (T2D) increases breast cancer risk and mortality, but there is limited experimental evidence supporting this…”
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BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR by Carboni, Joan M, Wittman, Mark, Yang, Zheng, Lee, Francis, Greer, Ann, Hurlburt, Warren, Hillerman, Stephen, Cao, Carolyn, Cantor, Glenn H, Dell-John, Janet, Chen, Cliff, Discenza, Lorell, Menard, Krista, Li, Aixin, Trainor, George, Vyas, Dolatrai, Kramer, Robert, Attar, Ricardo M, Gottardis, Marco M

“…BMS-754807 is a potent and reversible inhibitor of the insulin-like growth factor 1 receptor/insulin receptor family kinases (Ki, <2 nmol/L). It is currently…”
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Phosphorylated Insulin-Like Growth Factor-I/Insulin Receptor Is Present in All Breast Cancer Subtypes and Is Related to Poor Survival by LAW, Jennifer H, HABIBI, Golareh, NICHOLSON, Robert I, CARBONI, Joan, GOTTARDIS, Marco, POLLAK, Michael, DUNN, Sandra E, KAIJI HU, MASOUDI, Hamid, WANG, Michelle Y. C, STRATFORD, Anna L, PARK, Eugene, GEE, Julia M. W, FINLAY, Pauline, JONES, Helen E

“…Drugs that target the insulin-like growth factor-I receptor (IGF-IR) and/or insulin receptor (IR) are currently under investigation for a variety of…”
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Differential Mechanisms of Acquired Resistance to Insulin-like Growth Factor-I Receptor Antibody Therapy or to a Small-Molecule Inhibitor, BMS-754807, in a Human Rhabdomyosarcoma Model by FEI HUANG, HURLBURT, Warren, GREER, Ann, REEVES, Karen A, HILLERMAN, Stephen, HAN CHANG, FARGNOLI, Joseph, GRAF FINCKENSTEIN, Friedrich, GOTTARDIS, Marco M, CARBONI, Joan M

“…Agents targeting insulin-like growth factor-I receptor (IGF-IR), including antibodies and small-molecule inhibitors, are currently in clinical development for…”
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Constitutively Active Type I Insulin-Like Growth Factor Receptor Causes Transformation and Xenograft Growth of Immortalized Mammary Epithelial Cells and Is Accompanied by an Epithelial-to-Mesenchymal Transition Mediated by NF-κB and Snail by Kim, Hyun-Jung, Litzenburger, Beate C., Cui, Xiaojiang, Delgado, David A., Grabiner, Brian C., Lin, Xin, Lewis, Michael T., Gottardis, Marco M., Wong, Tai W., Attar, Ricardo M., Carboni, Joan M., Lee, Adrian V.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Insulin receptor isoform A and insulin-like growth factor II as additional treatment targets in human osteosarcoma by Avnet, Sofia, Sciacca, Laura, Salerno, Manuela, Gancitano, Giovanni, Cassarino, Maria Francesca, Longhi, Alessandra, Zakikhani, Mahvash, Carboni, Joan M, Gottardis, Marco, Giunti, Armando, Pollak, Michael, Vigneri, Riccardo, Baldini, Nicola

“…Despite the frequent presence of an insulin-like growth factor I receptor (IGFIR)-mediated autocrine loop in osteosarcoma (OS), interfering with this target…”
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Combined Inhibition of IGF-1R/IR and Src family kinases enhances antitumor effects in prostate cancer by decreasing activated survival pathways by Dayyani, Farshid, Parikh, Nila U, Varkaris, Andreas S, Song, Jian H, Moorthy, Shhyam, Chatterji, Tanushree, Maity, Sankar N, Wolfe, Adam R, Carboni, Joan M, Gottardis, Marco M, Logothetis, Christopher J, Gallick, Gary E

“…Treatment of metastatic prostate cancer (PCa) with single agents has shown only modest efficacy. We hypothesized dual inhibition of different pathways in PCa…”
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High IGF-IR Activity in Triple-Negative Breast Cancer Cell Lines and Tumorgrafts Correlates with Sensitivity to Anti-IGF-IR Therapy by LITZENBURGER, Beate C, CREIGHTON, Chad J, LEWIS, Michael T, RIMAWI, Mothaffar F, LEE, Adrian V, TSIMELZON, Anna, CHAN, Bonita T, HILSENBECK, Susan G, TAO WANG, CARBONI, Joan M, GOTTARDIS, Marco M, FEI HUANG, CHANG, Jenny C

“…We previously reported an insulin-like growth factor (IGF) gene expression signature, based on genes induced or repressed by IGF-I, which correlated with poor…”
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The Mechanisms of Differential Sensitivity to an Insulin-like Growth Factor-1 Receptor Inhibitor (BMS-536924) and Rationale for Combining with EGFR/HER2 Inhibitors by FEI HANG, GREET, Ann, LEE, Francis Y, GOTTARDIS, Marco M, CLARK, Edwin, HELMAN, Lee, ATTAR, Ricardo M, DONGRE, Ashok, CARBONIC, Joan M, HURLBURT, Warren, XIA HAN, HAFEZI, Rameh, WITTENBERG, Gayle M, REEVES, Karen, JIWEN CHEN, ROBINSON, Douglas, AIXIN LI

“…Overexpression and enhanced activity of insulin-like growth factor-I receptor (IGF-IR) in diverse tumor types make it an attractive target for cancer therapy…”
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HER receptor signaling confers resistance to the insulin-like growth factor-I receptor inhibitor, BMS-536924 by Haluska, Paul, Carboni, Joan M, TenEyck, Cynthia, Attar, Ricardo M, Hou, Xiaonan, Yu, Chunrong, Sagar, Malvika, Wong, Tai W, Gottardis, Marco M, Erlichman, Charles

“…We have reported previously the activity of the insulin-like growth factor-I (IGF-IR)/insulin receptor (InsR) inhibitor, BMS-554417, in breast and ovarian…”
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Dual IGF-1R/InsR Inhibitor BMS-754807 Synergizes with Hormonal Agents in Treatment of Estrogen-Dependent Breast Cancer by XIAONAN HOU, FEI HUANG, HALUSKA, Paul, MACEDO, Luciana F, HARRINGTON, Sean C, REEVES, Karen A, GREER, Ann, GRAF FINCKENSTEIN, Friedrich, BRODIE, Angela, GOTTARDIS, Marco M, CARBONI, Joan M

“…Insulin-like growth factor (IGF) signaling has been implicated in the resistance to hormonal therapy in breast cancer. Using a model of postmenopausal,…”
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Discovery of a 2,4-Disubstituted Pyrrolo[1,2-f][1,2,4]triazine Inhibitor (BMS-754807) of Insulin-like Growth Factor Receptor (IGF-1R) Kinase in Clinical Development by Wittman, Mark D, Carboni, Joan M, Yang, Zheng, Lee, Francis Y, Antman, Melissa, Attar, Ricardo, Balimane, Praveen, Chang, Chiehying, Chen, Cliff, Discenza, Lorell, Frennesson, David, Gottardis, Marco M, Greer, Ann, Hurlburt, Warren, Johnson, Walter, Langley, David R, Li, Aixin, Li, Jianqing, Liu, Peiying, Mastalerz, Harold, Mathur, Arvind, Menard, Krista, Patel, Karishma, Sack, John, Sang, Xiaopeng, Saulnier, Mark, Smith, Daniel, Stefanski, Kevin, Trainor, George, Velaparthi, Upender, Zhang, Guifen, Zimmermann, Kurt, Vyas, Dolatrai M

“…This report describes the biological activity, characterization, and SAR leading to 9d (BMS-754807) a small molecule IGF-1R kinase inhibitor in clinical…”
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ETV6-NTRK3―Mediated Breast Epithelial Cell Transformation Is Blocked by Targeting the IGF1R Signaling Pathway by TOGNON, Cristina E, SOMASIRI, Aruna M, SORENSEN, Poul H. B, EVDOKIMOVA, Valentina E, TRIGO, Genny, UY, Evett E, MELNYK, Nataliya, CARBONI, Joan M, GOTTARDIS, Marco M, ROSKELLEY, Calvin D, POLLAK, Michael

“…The insulin-like growth factor (IGF) 1 receptor (IGF1R) is an important therapeutic target under study in many cancers. Here, we describe a breast cancer model…”
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In vitro and in vivo antitumor effects of the dual insulin-like growth factor-I/insulin receptor inhibitor, BMS-554417 by Haluska, Paul, Carboni, Joan M, Loegering, David A, Lee, Francis Y, Wittman, Mark, Saulnier, Mark G, Frennesson, David B, Kalli, Kimberly R, Conover, Cheryl A, Attar, Ricardo M, Kaufmann, Scott H, Gottardis, Marco, Erlichman, Charles

“…The insulin-like growth factor receptor (IGF-IR) and insulin receptor are either overactivated and/or overexpressed in a wide range of tumor types and…”
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IRS2 copy number gain, KRAS and BRAF mutation status as predictive biomarkers for response to the IGF-1R/IR inhibitor BMS-754807 in colorectal cancer cell lines by Huang, Fei, Chang, Han, Greer, Ann, Hillerman, Stephen, Reeves, Karen A, Hurlburt, Warren, Cogswell, John, Patel, Dharmesh, Qi, Zhenhao, Fairchild, Craig, Ryseck, Rolf-Peter, Wong, Tai W, Finckenstein, Friedrich G, Jackson, Jeffrey, Carboni, Joan M

“…Insulin-like growth factor receptor 1 (IGF-1R)-targeting therapies are currently at an important crossroad given the low clinical response rates seen in…”
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Molecular markers for novel therapies in neuroendocrine (carcinoid) tumors by Gilbert, Judith A, Adhikari, Laura J, Lloyd, Ricardo V, Rubin, Joseph, Haluska, Paul, Carboni, Joan M, Gottardis, Marco M, Ames, Matthew M

“…Neuroendocrine (carcinoid) tumors (NETs) are endocrine neoplasms occurring most frequently in gastrointestinal and bronchopulmonary (BP) systems. The majority…”
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Synthetic Lethality Screens Reveal RPS6 and MST1R as Modifiers of Insulin-like Growth Factor-1 Receptor Inhibitor Activity in Childhood Sarcomas by POTRATZ, Jenny C, SAUNDERS, Darren N, APARICIO, Samuel A, SORENSEN, Poul H. B, WAI, Daniel H, NG, Tony L, MCKINNEY, Steven E, CARBONI, Joan M, GOTTARDIS, Marco M, TRICHE, Timothy J, JÜRGENS, Heribert, POLLAK, Michael N

“…The insulin-like growth factor-1 receptor (IGF1R) is emerging as a promising therapeutic target in human cancers. In the high-risk childhood sarcomas Ewing…”
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IGFBP Ratio Confers Resistance to IGF Targeting and Correlates with Increased Invasion and Poor Outcome in Breast Tumors by BECKER, Marc A, XIAONAN HOU, HARRINGTON, Sean C, WEROHA, S. John, GONZALEZ, Sergio E, JACOB, Kristina A, CARBONI, Joan M, GOTTARDIS, Marco M, HAIUSKA, Paul

“…To improve the significance of insulin-like growth factor-binding protein 5 (IGFBP-5) as a prognostic and potentially predictive marker in patients with breast…”
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IGF1/insulin receptor kinase inhibition by BMS-536924 is better tolerated than alloxan-induced hypoinsulinemia and more effective than metformin in the treatment of experimental insulin-responsive breast cancer by Dool, Carly Jade, Mashhedi, Haider, Zakikhani, Mahvash, David, Stéphanie, Zhao, Yunhua, Birman, Elena, Carboni, Joan M, Gottardis, Marco, Blouin, Marie-José, Pollak, Michael

“…Epidemiologic and experimental evidence suggest that a subset of breast cancer is insulin responsive, but it is unclear whether safe and effective therapies…”
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Expression of Insulin Receptor Isoform A and Insulin-like Growth Factor-1 Receptor in Human Acute Myelogenous Leukemia: Effect of the Dual-Receptor Inhibitor BMS-536924 In vitro by WAHNER HENDRICKSON, Andrea E, HALUSKA, Paul, CARBONI, Joan M, KAUFMANN, Scott H, SCHNEIDER, Paula A, LOEGERING, David A, PETERSON, Kevin L, ATTAR, Ricardo, SMITH, B. Douglas, ERLICHMAN, Charles, GOTTARDIS, Marco, KARP, Judith E

“…The insulin receptor (IR) and insulin-like growth factor-1 receptor (IGF1R) are receptor tyrosine kinases that participate in mitogenic and antiapoptotic…”
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