Search Results - "João Rocha"

Toxicology and pharmacology of selenium: emphasis on synthetic organoselenium compounds by Nogueira, Cristina W., Rocha, João B. T.

“…The advance in the area of synthesis and reactivity of organoselenium, as well as the discovery that selenium was the cause of severe intoxication episodes of…”
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Mechanisms of methylmercury-induced neurotoxicity: Evidence from experimental studies by Farina, Marcelo, Rocha, João B.T., Aschner, Michael

“…Neurological disorders are common, costly, and can cause enduring disability. Although mostly unknown, a few environmental toxicants are recognized causes of…”
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Toxicology and pharmacology of synthetic organoselenium compounds: an update by Nogueira, Cristina W., Barbosa, Nilda V., Rocha, João B. T.

“…Here, we addressed the pharmacology and toxicology of synthetic organoselenium compounds and some naturally occurring organoselenium amino acids. The use of…”
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Streptozotocin induces brain glucose metabolic changes and alters glucose transporter expression in the Lobster cockroach; Nauphoeta cinerea (Blattodea: Blaberidae) by Olagoke, Olawande C., Afolabi, Blessing A., Rocha, João B. T.

“…The development of new models to study diabetes in invertebrates is important to ensure adherence to the 3R’s principle and to expedite knowledge of the…”
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In the Chalcogenoxide Elimination Panorama: Systematic Insight into a Key Reaction by Madabeni, Andrea, Zucchelli, Simone, Nogara, Pablo A., Rocha, João B. T., Orian, Laura

“…The selenoxide elimination is a well-known reaction in organochalcogen chemistry, with wide synthetic, biological, and toxicological implications. In this…”
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Toxicity of ethylmercury (and Thimerosal): a comparison with methylmercury by Dórea, José G., Farina, Marcelo, Rocha, João B. T.

“…ABSTRACT Ethylmercury (etHg) is derived from the metabolism of thimerosal (o‐carboxyphenyl‐thio‐ethyl‐sodium salt), which is the most widely used form of…”
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Sulfhydryl groups as targets of mercury toxicity by Ajsuvakova, Olga P., Tinkov, Alexey A., Aschner, Michael, Rocha, João B.T., Michalke, Bernhard, Skalnaya, Margarita G., Skalny, Anatoly V., Butnariu, Monica, Dadar, Maryam, Sarac, Ioan, Aaseth, Jan, Bjørklund, Geir

“…•Interaction of Hg with biomolecules is mediated through its affinity to Cys thiol.•Cys and GSH Hg-conjugates play a significant role in Hg transport in…”
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Effect of Methylmercury Binding on the Peroxide-Reducing Potential of Cysteine and Selenocysteine by Madabeni, Andrea, Nogara, Pablo A, Bortoli, Marco, Rocha, João B. T, Orian, Laura

“…Methylmercury (CH3Hg+) binding to catalytically fundamental cysteine and selenocysteine of peroxide-reducing enzymes has long been postulated as the origin of…”
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Aqueous two‐phase systems and monolithic chromatography as alternative technological platforms for virus and virus‐like particle purification by Rocha, João M

“…There is a rising interest in viral and non‐viral gene delivery vehicles for human gene therapy and vaccination applications, and these vehicles include…”
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An assessment of the rescue action of resveratrol in parkin loss of function-induced oxidative stress in Drosophila melanogaster by Adedara, Adeola O., Babalola, Ayoade D., Stephano, Flora, Awogbindin, Ifeoluwa O., Olopade, James O., Rocha, João B. T., Whitworth, Alexander J., Abolaji, Amos O.

“…Loss-of-function mutations in parkin is associated with onset of juvenile Parkinson’s disease (PD). Resveratrol is a polyphenolic stilbene with neuroprotective…”
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New Organochalcogen Multitarget Drug: Synthesis and Antioxidant and Antitumoral Activities of Chalcogenozidovudine Derivatives by de Souza, Diego, Mariano, Douglas O. C, Nedel, Fernanda, Schultze, Eduarda, Campos, Vinícius F, Seixas, Fabiana, da Silva, Rafael S, Munchen, Taiana S, Ilha, Vinicius, Dornelles, Luciano, Braga, Antonio L, Rocha, João B. T, Collares, Tiago, Rodrigues, Oscar E. D

“…In this article we present the synthesis, characterization, and in vitro biological and biochemical activities of new chalcogenozidovudine derivatives as…”
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Organoselenium compounds as mimics of selenoproteins and thiol modifier agents by Barbosa, Nilda V, Nogueira, Cristina W, Nogara, Pablo A, de Bem, Andreza F, Aschner, Michael, Rocha, João B T

“…Selenium is an essential trace element for animals and its role in the chemistry of life relies on a unique functional group: the selenol (-SeH) group. The…”
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Biomarkers of mercury toxicity: Past, present, and future trends by Branco, Vasco, Caito, Sam, Farina, Marcelo, Teixeira da Rocha, João, Aschner, Michael, Carvalho, Cristina

“…Mercury (Hg) toxicity continues to represent a global health concern. Given that human populations are mostly exposed to low chronic levels of mercurial…”
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On the valorization of lactose and its derivatives from cheese whey as a dairy industry by-product: an overview by Rocha, João M., Guerra, Alexandra

“…The resulting whey from cheese manufacture consists mainly of water and lactose, a sugar with little sweetening and fermentable power and low commercial value…”
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Factors Associated with COVID-19 Vaccine Hesitancy by Soares, Patricia, Rocha, João Victor, Moniz, Marta, Gama, Ana, Laires, Pedro Almeida, Pedro, Ana Rita, Dias, Sónia, Leite, Andreia, Nunes, Carla

“…It is critical to develop tailored strategies to increase acceptability of the COVID-19 vaccine and decrease hesitancy. Hence, this study aims to assess and…”
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Avoidable hospitalizations in Brazil and Portugal: Identifying and comparing critical areas through spatial analysis by Rocha, João Victor Muniz, Nunes, Carla, Santana, Rui

“…Hospitalizations for ambulatory care sensitive conditions have been used to assess the performance of primary health care. Few studies have compared geographic…”
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Developmental Methylmercury Exposure Induced and Age-Dependent Glutamatergic Neurotoxicity in Caenorhabditis elegans by Ke, Tao, Santamaria, Abel, Barbosa, Fernando, Rocha, João B. T., Skalny, Anatoly V., Tinkov, Alexey A., Bowman, Aaron B., Aschner, Michael

“…Developmental methylmercury (MeHg) exposures cause latent neurotoxic effects in adults; however, the mechanisms underlying the latent neurotoxicity are not…”
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The importance of inflammatory biomarkers in non-specific acute and chronic low back pain: a systematic review by Pinto, Eduardo Moreira, Neves, João Rocha, Laranjeira, Manuel, Reis, Joaquim

“…Objective The purpose of this study was to systematically review the evidence on inflammatory biomarkers as analytic predictors of non-specific low back pain…”
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Methylmercury's chemistry: From the environment to the mammalian brain by Nogara, Pablo A., Oliveira, Cláudia S., Schmitz, Gabriela L., Piquini, Paulo C., Farina, Marcelo, Aschner, Michael, Rocha, João B.T.

“…Methylmercury is a neurotoxicant that is found in fish and rice. MeHg's toxicity is mediated by blockage of -SH and -SeH groups of proteins. However, the…”
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Brain diseases in changing climate by Ruszkiewicz, Joanna A., Tinkov, Alexey A., Skalny, Anatoly V., Siokas, Vasileios, Dardiotis, Efthimios, Tsatsakis, Aristidis, Bowman, Aaron B., da Rocha, João B.T., Aschner, Michael

“…Climate change is one of the biggest and most urgent challenges for the 21st century. Rising average temperatures and ocean levels, altered precipitation…”
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