Search Results - "João Ernesto Carvalho"

Synthesis of thiophene-thiosemicarbazone derivatives and evaluation of their in vitro and in vivo antitumor activities by de Oliveira, Jamerson Ferreira, da Silva, Anekécia Lauro, Vendramini-Costa, Débora Barbosa, da Cruz Amorim, Cezar Augusto, Campos, Júlia Furtado, Ribeiro, Amélia Galdino, Olímpio de Moura, Ricardo, Neves, Jorge Luiz, Ruiz, Ana Lúcia Tasca Gois, Ernesto de Carvalho, João, Alves de Lima, Maria do Carmo

“…A series of thiophene-2-thiosemicarbazones derivatives (5–14) was synthesized, characterized and evaluated for their antitumor activity. They were tested…”
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Reversal of Ovarian Cancer Cell Lines Multidrug Resistance Phenotype by the Association of Apiole with Chemotherapies by Afonso de Lima, Carolina, de Souza Bueno, Ian Lucas, Nunes Siqueira Vasconcelos, Stanley, Sciani, Juliana Mozer, Ruiz, Ana Lúcia Tasca Gois, Foglio, Mary Ann, Carvalho, João Ernesto de, Barbarini Longato, Giovanna

“…Multidrug resistance (MDR) is the main obstacle in anticancer therapy. The use of drug combinations to circumvent tumor resistance is a well-established…”
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Antiproliferative activity and induction of apoptosis in PC-3 cells by the chalcone cardamonin from Campomanesia adamantium (Myrtaceae) in a bioactivity-guided study by Pascoal, Aislan Cristina Rheder Fagundes, Ehrenfried, Carlos Augusto, Lopez, Begoña Gimenez-Cassina, de Araujo, Thiago Matos, Pascoal, Vinicius D'ávila Bitencourt, Gilioli, Rovilson, Anhê, Gabriel Forato, Ruiz, Ana Lúcia Tasca Goes, Carvalho, João Ernesto de, Stefanello, Maria Elida Alves, Salvador, Marcos José

“…The Myrtaceae family is a common source of medicines used in the treatment of numerous diseases in South America. In Brazil, fruits of the Campomanesia species…”
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Design and Synthesis of N-Acylated Aza-Goniothalamin Derivatives and Evaluation of Their in vitro and in vivo Antitumor Activity by Barcelos, Rosimeire Coura, Pastre, Julio Cezar, Vendramini-Costa, Débora Barbosa, Caixeta, Vanessa, Longato, Giovanna Barbarini, Monteiro, Paula Araújo, de Carvalho, João Ernesto, Pilli, Ronaldo Aloise

“…Herein we describe the synthesis of a focused library of compounds based on the structure of goniothalamin (1) and the evaluation of the potential antitumor…”
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Synthesis, Antitumor, Antitrypanosomal and Antileishmanial Activities of Benzo[4,5]canthin-6-ones Bearing the N′-(Substituted benzylidene)-carbohydrazide and N-Alkylcarboxamide Groups at C-2 by Camila Mareco Bento Leite Silva, Garcia, Francielle Pelegrin, Jean Henrique da Silva Rodrigues, Nakamura, Celso Vataru, Ueda-Nakamura, Tania, Meyer, Emerson, Ana Lucia Tasca Gois Ruiz, Foglio, Mary Ann, Carvalho, João Ernesto de, Costa, Willian Ferreira da, Sarragiotto, Maria Helena

“…A series of novel benzo[4,5]canthin-6-ones, bearing the N′-(substituted benzylidene)-carbohydrazide (11a-e) and N-alkylcarboxamide (13a-g) moieties at…”
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7,7-Dimethylaporphine and Other Alkaloids from the Bark of Guatteria friesiana by Costa, Emmanoel V, Pinheiro, Maria Lúcia B, Maia, Beatriz Helena L. N. S, Marques, Francisco A, Ruiz, Ana Lúcia T. G, Marchetti, Gabriela M, Carvalho, João Ernesto de, Soares, Milena B. P, Costa, Cinara O. S, Galvão, Alexandre F. C, Lopes, Norberto P, Koolen, Hector H. F, Bezerra, Daniel P, Barison, Andersson

“…Phytochemical investigation of the bark of Guatteria friesiana afforded 12 new aporphines (1–12), along with nine known alkaloids (13–21). The structures of…”
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Copper(II) Nitroaromatic Schiff Base Complexes: Synthesis, Biological Activity and Their Interaction with DNA and Albumins by Martins, Darliane A., Bomfim Filho, Lucius F., Silva, Cleiton M. da, Fátima, Ângelo de, Louro, Sonia R. W., Batista, Denise G. J., Soeiro, Maria de Nazaré C., Carvalho, João Ernesto de, Teixeira, Letícia R.

“…Copper(II) complexes of the Schiff base ligands 2-((5-nitrofuran-2-yl)methyleneamino)phenol (HL1) and 2-(4-nitrobenzylideneamino)phenol (HL2) were prepared and…”
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Antiulcerative and Antinociceptive Activities of Casein and Whey Proteins by Carrillo, Wilman, Monteiro, Karin Maia, Spindola, Humberto, Ramos, Mercedes, de Carvalho, João Ernesto

“…The aim of this study was to evaluate the antiulcerative and antinociceptive activities of milk proteins using the induced gastric ulcer with ethanol rat model…”
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Chemical constituents isolated from the bark of Guatteria blepharophylla (Annonaceae) and their antiproliferative and antimicrobial activities by Costa, Emmanoel V., Marques, Francisco de Assis, Pinheiro, Maria Lúcia B., Braga, Raquel M., Delarmelina, Camila, Duarte, Marta Cristina T., Ruiz, Ana Lúcia T. G., Carvalho, João Ernesto de, Maia, Beatriz H. L. N. S.

“…Phytochemical study of the bark of Guatteria blepharophylla (Mart.) Mart. afforded twelve compounds, namely two sesquiterpenes, caryophyllene oxide (1) and…”
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Antiproliferative Activity of Three Methoxylated Flavonoids Isolated from Zeyheria montana Mart. (Bignoniaceae) Leaves by Seito, Leonardo Noboru, Ruiz, Ana Lucia Tasca Goiz, Vendramini‐Costa, Debora, Tinti, Sirlene Valério, Carvalho, João Ernesto, Bastos, Jairo Kenupp, Di Stasi, Luiz Claudio

“…The present study isolated three major active flavonoids, two flavones named 4’,5,7‐trimethoxy‐luteolin (1) and 6‐hydroxy‐5,7‐dimethoxyflavone (2) and the…”
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Aporphine and Tetrahydroprotoberberine Alkaloids from the Leaves of Guatteria friesiana (Annonaceae) and their Cytotoxic Activities by Costa, Emmanoel Vilaça, Cruz, Pedro Ernesto O. da, Pinheiro, Maria Lúcia B., Marques, Francisco A., Ruiz, Ana Lúcia T. G., Marchetti, Gabriela M., Carvalho, João Ernesto de, Barison, Andersson, Maia, Beatriz Helena L. N. S.

“…Phytochemical investigation of the leaves of Guatteria friesiana (Annonaceae) afforded three new isoquinoline alkaloids, 13-hydroxy-discretinine,…”
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Açaí (Euterpe oleracea Mart) Consumption and Prevention of Chronic Diseases: Is There an Association? A Preliminary Study by Rosa, Ivone Garros, de Carvalho, João Ernesto, Soares Brandão Nascimento, Maria do Desterro, Muniz Filho, Walbert Edson, Bezerra, Geusa Felipa de Barros, Brito, Luciane Maria Oliveira, Barbosa, Maria do Carmo Lacerda, Vidal, Flávia Castello Branco, Rodrigues, Gabrielle Meirelles, Custódio Neto da Silva, Marcos Antonio, Silva, Dulcelena Ferreira, Borges, Katia Regina Assunção

“…Background. Flavonoids from a variety of fruits, including açaí, have beneficial antioxidant activity in several diseases, including cancer. Breast cancer is…”
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Synthesis and differential antiproliferative activity of Biginelli compounds against cancer cell lines: Monastrol, oxo-monastrol and oxygenated analogues by Russowsky, Dennis, Canto, Rômulo F.S., Sanches, Sergio A.A., D’Oca, Marcelo G.M., de Fátima, Ângelo, Pilli, Ronaldo A., Kohn, Luciana K., Antônio, Márcia A., de Carvalho, João Ernesto

“…The synthesis and differential antiproliferative activity of monastrol ( 1a), oxo-monastrol ( 1b) and eight oxygenated derivatives 3a, b– 6a, b on seven human…”
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Biological activities of the essential oil from the leaves of Xylopia laevigata (Annonaceae) by Costa, Emmanoel Vilaça, Silva, Thanany Brasil da, Menezes, Leociley Rocha Alencar, Ribeiro, Luis Henrique Gonzaga, Gadelha, Fernanda Ramos, Carvalho, João Ernesto de, Souza, Lígia Moraes Barizon de, Silva, Mario Antonio Navarro da, Siqueira, Carlos Alberto Theodoro, Salvador, Marcos José

“…The essential oil from the leaves of Xylopia laevigata was obtained by hydrodistillation and analyzed by gas chromatography/mass spectrometry (GC/MS) and…”
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Synthesis, antiproliferative activity and molecular properties predictions of galloyl derivatives by da Silva, Marciane Maximo, Comin, Marina, Duarte, Thiago Santos, Foglio, Mary Ann, de Carvalho, João Ernesto, do Vieira, Maria Carmo, Formagio, Anelise Samara Nazari

“…The present study was designed to investigate the in vitro antiproliferative activity against ten human cancer cell lines of a series of galloyl derivatives…”
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Antimicrobial and antiproliferative activities of stingless bee Melipona scutellaris geopropolis by da Cunha, Marcos Guilherme, Franchin, Marcelo, de Carvalho Galvão, Lívia Câmara, de Ruiz, Ana Lúcia Tasca Góis, de Carvalho, João Ernesto, Ikegaki, Masarahu, de Alencar, Severino Matias, Koo, Hyun, Rosalen, Pedro Luiz

“…Geopropolis is a type of propolis containing resin, wax, and soil, collected by threatened stingless bee species native to tropical countries and used in folk…”
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Anti-Estrogenic Activity of Guajadial Fraction, from Guava Leaves ( Psidium guajava L.) by Bazioli, Jaqueline Moraes, Costa, Jonas Henrique, Shiozawa, Larissa, Ruiz, Ana Lúcia Tasca Gois, Foglio, Mary Ann, Carvalho, João Ernesto de

“…The research of natural products has allowed for the discovery of biologically relevant compounds inspired by plant secondary metabolites, which contributes to…”
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Antioxidant, anti-inflammatory, antiproliferative and antimycobacterial activities of the essential oil of Psidium guineense Sw. and spathulenol by do Nascimento, Kamilla Felipe, Moreira, Flora Martinez Figueira, Alencar Santos, Joyce, Kassuya, Candida Aparecida Leite, Croda, Julio Henrique Rosa, Cardoso, Claudia Andrea Lima, Vieira, Maria do Carmo, Góis Ruiz, Ana Lúcia Tasca, Ann Foglio, Mary, de Carvalho, João Ernesto, Formagio, Anelise Samara Nazari

“…Leaves from Psidium guineense Sw. are used in popular medicine for the treatment of inflammatory disease. However, there is no scientific evidence…”
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Synthesis, DNA Binding, and Antiproliferative Activity of Novel Acridine-Thiosemicarbazone Derivatives by de Almeida, Sinara Mônica Vitalino, Lafayette, Elizabeth Almeida, da Silva, Lúcia Patrícia Bezerra Gomes, Amorim, Cézar Augusto da Cruz, de Oliveira, Tiago Bento, Ruiz, Ana Lucia Tasca Gois, de Carvalho, João Ernesto, de Moura, Ricardo Olímpio, Beltrão, Eduardo Isidoro Carneiro, de Lima, Maria do Carmo Alves, de Carvalho Júnior, Luiz Bezerra

“…In this work, the acridine nucleus was used as a lead-compound for structural modification by adding different substituted thiosemicarbazide moieties. Eight…”
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Chitosan-tripolyphosphate nanoparticles as Arrabidaea chica standardized extract carrier: synthesis, characterization, biocompatibility, and antiulcerogenic activity by Servat-Medina, Leila, González-Gómez, Alvaro, Reyes-Ortega, Felisa, Sousa, Ilza Maria Oliveira, Queiroz, Nubia de Cássia Almeida, Zago, Patricia Maria Wiziack, Jorge, Michelle Pedrosa, Monteiro, Karin Maia, de Carvalho, João Ernesto, San Román, Julio, Foglio, Mary Ann

“…Natural products using plants have received considerable attention because of their potential to treat various diseases. Arrabidaea chica (Humb. & Bonpl.) B…”
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