Search Results - "Jjunju, Samuel"
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Single-Dose Liposomal Amphotericin B Treatment for Cryptococcal Meningitis
Published in The New England journal of medicine (24-03-2022)“…Cryptococcal meningitis is a major complication of HIV infection. In this phase 3, randomized, controlled trial in sub-Saharan Africa, a single dose of…”
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Persistently elevated intracranial pressure in cryptococcal meningitis– 76 therapeutic lumbar punctures
Published in Medical mycology case reports (01-06-2023)“…Cryptococcal meningitis still remains the most common form of adult meningitis in sub-Saharan Africa, due to the burden of HIV/AIDS. Increased intracranial…”
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Distal jejunal obstruction due to Cryptococcus neoformans and rifampicin-resistant Mycobacterium tuberculosis co-infection: A case report
Published in Medical mycology case reports (01-12-2022)“…Jejunal obstruction secondary to Cryptococcus neoformans and rifampicin-resistant Mycobacterium tuberculosis co-infection in HIV is not previously reported…”
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Early empiric anti-Mycobacterium tuberculosis therapy for sepsis in sub-Saharan Africa: a protocol of a randomised clinical trial
Published in BMJ open (06-06-2022)“…IntroductionSub-Saharan Africa shoulders the highest burden of global sepsis and associated mortality. In high HIV and tuberculosis (TB) prevalent settings…”
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Diagnostic and Prognostic Value of Cerebrospinal Fluid Lactate and Glucose in HIV-Associated Tuberculosis Meningitis
Published in Microbiology spectrum (31-08-2022)“…The role of cerebrospinal fluid (CSF) lactate in tuberculosis meningitis (TBM) diagnosis and prognosis is unclear. The aim of this study was to evaluate the…”
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The role of optic nerve sheath diameter ultrasound in brain infection
Published in eNeurologicalSci (01-06-2021)“…Brain infections cause significant morbidity and mortality worldwide, especially in resource-limited settings with high HIV co-infection rates. Raised…”
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Outpatient Cryptococcal Antigen Screening Is Associated With Favorable Baseline Characteristics and Improved Survival in Persons With Cryptococcal Meningitis in Uganda
Published in Clinical infectious diseases (08-02-2023)“…It is unknown whether persons with symptomatic cryptococcal meningitis detected during routine blood cryptococcal antigen (CrAg) screening have better survival…”
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Clinical importance of cerebrospinal fluid protein levels in HIV-associated cryptococcal meningitis: Insights from a prospective cohort study in Uganda
Published in Medical mycology (Oxford) (04-10-2024)“…Cerebrospinal fluid (CSF) protein levels exhibit high variability in HIV-associated cryptococcal meningitis; however, its clinical implications remain unclear…”
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Determinants of cryptococcal antigen (CrAg) screening uptake in Kampala, Uganda: An assessment of health center characteristics
Published in Medical mycology (Oxford) (01-04-2022)“…Cryptococcal antigen (CrAg) screening and pre-emptive antifungal therapy for people with CD4 cell counts <100 cells/μl are recommended by the World Health…”
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Cost-effectiveness of single, high-dose, liposomal amphotericin regimen for HIV-associated cryptococcal meningitis in five countries in sub-Saharan Africa: an economic analysis of the AMBITION-cm trial
Published in The Lancet global health (01-12-2022)“…HIV-associated cryptococcal meningitis is a leading cause of AIDS-related mortality. The AMBITION-cm trial showed that a regimen based on a single high dose of…”
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Association of Hyponatremia on Mortality in Cryptococcal Meningitis: A Prospective Cohort
Published in Open forum infectious diseases (01-07-2022)“…Abstract Background Sodium abnormalities are frequent in central nervous system infections and may be caused by cerebral salt wasting, syndrome of…”
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5-Flucytosine Longitudinal Antifungal Susceptibility Testing of Cryptococcus neoformans : A Substudy of the EnACT Trial Testing Oral Amphotericin
Published in Open forum infectious diseases (01-12-2023)“…The EnACT trial was a phase 2 randomized clinical trial conducted in Uganda, which evaluated a novel orally delivered lipid nanocrystal (LNC) amphotericin B in…”
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