Search Results - "Jirholt, P"

Memory B Cells in Mouse Models by Bergmann, B., Grimsholm, O., Thorarinsdottir, K., Ren, W., Jirholt, P., Gjertsson, I., Mårtensson, I.‐L.

“…One of the principles behind vaccination, as shown by Edward Jenner in 1796, and host protection is immunological memory, and one of the cells central to this…”
Get full text

Systemic cytokine signaling via IL-17 in smokers with obstructive pulmonary disease: a link to bacterial colonization? by Andelid, Kristina, Tengvall, Sara, Andersson, Anders, Levänen, Bettina, Christenson, Karin, Jirholt, Pernilla, Åhrén, Christina, Qvarfordt, Ingemar, Ekberg-Jansson, Ann, Lindén, Anders

“…We examined whether systemic cytokine signaling via interleukin (IL)-17 and growth-related oncogene-α (GRO-α) is impaired in smokers with obstructive pulmonary…”
Get full text

Systemic signs of neutrophil mobilization during clinically stable periods and during exacerbations in smokers with obstructive pulmonary disease by Andelid, Kristina, Andersson, Anders, Yoshihara, Shigemi, Åhrén, Christina, Jirholt, Pernilla, Ekberg-Jansson, Ann, Lindén, Anders

“…It is still unclear whether signs of neutrophil mobilization in the blood of patients with chronic obstructive pulmonary disease represent true systemic events…”
Get full text

Evaluation of macrophage-specific promoters using lentiviral delivery in mice by Levin, M C, Lidberg, U, Jirholt, P, Adiels, M, Wramstedt, A, Gustafsson, K, Greaves, D R, Li, S, Fazio, S, Linton, M F, Olofsson, S-O, Borén, J, Gjertsson, I

“…In gene therapy, tissue-specific promoters are useful tools to direct transgene expression and improve efficiency and safety. Macrophage-specific promoters…”
Get full text

Exploiting sequence space: shuffling in vivo formed complementarity determining regions into a master framework by Jirholt, P, Ohlin, M, Borrebaeck, C.A.K, Söderlind, E

“…A novel approach in molecular design is presented, where in vivo formed complementarity determining regions (CDR) from antibody genes were shuffled into a…”
Get full text

Retention of atherogenic lipoproteins in atherogenesis by Gustafsson, M, Flood, C, Jirholt, P, Borén, J

“…Atherosclerosis is a multifactorial disease whose pathogenesis is still unclear. Mounting evidence, however, supports the concept that subendothelial retention…”
Get full text

A central core structure in an antibody variable domain determines antigen specificity by Jirholt, Pernilla, Strandberg, Leif, Jansson, Bo, Krambovitis, Elias, Söderlind, Eskil, Borrebaeck, Carl A.K., Carlsson, Roland, Danielsson, Lena, Ohlin, Mats

“…Antibody binding sites provide an adaptable surface capable of interacting with essentially any molecular target. Using CDR shuffling, residues important for…”
Get full text

Gene Therapy Induces Antigen-Specific Tolerance in Experimental Collagen-Induced Arthritis by Tengvall, Sara, Eneljung, Tove, Jirholt, Pernilla, Turesson, Olof, Wing, Kajsa, Holmdahl, Rikard, Kihlberg, Jan, Stern, Anna, Mårtensson, Inga-Lill, Henningsson, Louise, Gustafsson, Kenth, Gjertsson, Inger

“…Here, we investigate induction of immunological tolerance by lentiviral based gene therapy in a mouse model of rheumatoid arthritis, collagen II-induced…”
Get full text

Collagen epitope expression on B cells is sufficient to confer tolerance to collagen-induced arthritis by Andersson, Sofia E M, Eneljung, Tove, Tengvall, Sara, Jirholt, Pernilla, Stern, Anna, Henningsson, Louise, Liang, Bibo, Thorarinsdottir, Katrin, Kihlberg, Jan, Holmdahl, Rikard, Mårtensson, Inga-Lill, Gustafsson, Kenth, Gjertsson, Inger

“…The mechanisms underlying tolerance induction and maintenance in autoimmune arthritis remain elusive. In a mouse model of rheumatoid arthritis, collagen type…”
Get full text

Rip2 Deficiency Leads to Increased Atherosclerosis Despite Decreased Inflammation by Levin, Malin C., Jirholt, Pernilla, Wramstedt, Anna, Johansson, Maria E., Lundberg, Anna M., Trajkovska, Maria Gustafsson, Ståhlman, Marcus, Fogelstrand, Per, Brisslert, Mikael, Fogelstrand, Linda, Yan, Zhong-Qun, Hansson, Göran K., Björkbacka, Harry, Olofsson, Sven-Olof, Borén, Jan

“…The innate immune system and in particular the pattern-recognition receptors Toll-like receptors have recently been linked to atherosclerosis. Consequently,…”
Get full text

Interleukin 15 Mediates Joint Destruction in Staphylococcus Aureus Arthritis by Henningsson, Louise, Jirholt, Pernilla, Bogestål, Yalda Rahpeymai, Eneljung, Tove, Adiels, Martin, Lindholm, Catharina, McInnes, Iain, Bulfone-Paus, Silvia, Lerner, Ulf H., Gjertsson, Inger

“…Background. Staphylococcus aureus arthritis causes severe and rapid joint damage despite antibiotics. Thus, there is a need to identify new treatment targets…”
Get full text

Recombining germline-derived CDR sequences for creating diverse single-framework antibody libraries by Söderlind, Eskil, Strandberg, Leif, Jirholt, Pernilla, Kobayashi, Norihiro, Alexeiva, Vessela, Åberg, Anna-Maria, Nilsson, Anna, Jansson, Bo, Ohlin, Mats, Wingren, Christer, Danielsson, Lena, Carlsson, Roland, Borrebaeck, Carl A.K

“…We constructed a single-chain Fv antibody library that permits human complementarity-determining region (CDR) gene fragments of any germline to be incorporated…”
Get full text

Length of the antibody heavy chain complementarity determining region 3 as a specificity-determining factor by Barrios, Yvelise, Jirholt, Pernilla, Ohlin, Mats

“…The antigen binding site of an antibody is made up of residues residing in six hypervariable loops of the heavy and light chains. In most cases several or all…”
Get full text

Negative feedback on IL-23 exerted by IL-17A during pulmonary inflammation by Silverpil, Elin, Wright, Adam K A, Hansson, Marit, Jirholt, Pernilla, Henningsson, Louise, Smith, Margaretha E, Gordon, Stephen B, Iwakura, Yoichiro, Gjertsson, Inger, Glader, Pernilla, Lindén, Anders

“…It is now established that IL-17 has a broad pro-inflammatory potential in mammalian host defense, in inflammatory disease and in autoimmunity, whereas little…”
Get more information

Antigen-Specific Gene Therapy after Immunisation Reduces the Severity of Collagen-Induced Arthritis by Gjertsson, Inger, Holmdahl, Rikard, Henningsson, Louise, Jirholt, Pernilla, Tengvall, Sara, Eneljung, Tove, Gustafsson, Kenth

“…Reestablishment of tolerance induction in rheumatoid arthritis (RA) would be an optimal treatment with few, if any, side effects. However, to develop such a…”
Get full text

Endogenous B-cell-targeted antigen expression induces tolerance to collagen type II arthritis in mice by Andersson, S, Eneljung, T, Tengvall, S, Martensson, L, Gustafsson, K, Rikard, H, Kihlberg, J, Stern, A, Jirholt, P, Gjertsson, I

Get full text

Endogenous B Cell-targeted Antigen Expression Induces Tolerance to Collagen Type ii Arthritis in Mice by Andersson, S, Eneljung, T, Tengvall, S, Martensson, IL, Gustafsson, K, Holmdahl, R, Kihlberg, J, Stern, A, Jirholt, P, Gjertsson, I

Get full text

How Does Mutant Proprotein Convertase Neural Apoptosis-Regulated Convertase 1 Induce Autosomal Dominant Hypercholesterolemia? by Jirholt, Pernilla, Adiels, Martin, Borén, Jan

Get full text

Antibody Evolution from the Centre to the Periphery: Applied to a Human Antibody Fragment Recognising the Tumour-associated Antigen Mucin-1 by Jirholt, Pernilla, Borrebaeck, Carl A.K., Ohlin, Mats

“…Mucin-1 has proven to be a suitable target for antibody-based diagnosis and therapy of certain tumours, but no appropriate human antibody or antibody fragment…”
Get full text

135 RIP2 LINKS IMMUNE SIGNALING AND SUBENDOTHELIAL LIPID ACCUMULATION BY REGULATING TLR4-DEPENDENT LIPID UPTAKE IN MACROPHAGES by Levin, M., Jirholt, P., Johansson, M., Wramstedt, A., Lundberg, A., Ståhlman, M., Fogelstrand, P., Brisslert, M., Yan, Z.-Q., Hansson, G., Björkbacka, H., Olofsson, S.-O., Borén, J.

Get full text