Search Results - "Jirgis, Ehab N.M."

Structural Views along the Mycobacterium tuberculosis MenD Reaction Pathway Illuminate Key Aspects of Thiamin Diphosphate-Dependent Enzyme Mechanisms by Jirgis, Ehab N.M., Bashiri, Ghader, Bulloch, Esther M.M., Johnston, Jodie M., Baker, Edward N.

“…Menaquinone (MQ) is an essential component of the respiratory chains of many pathogenic organisms, including Mycobacterium tuberculosis (Mtb). The first…”
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A revised biosynthetic pathway for the cofactor F 420 in prokaryotes by Bashiri, Ghader, Antoney, James, Jirgis, Ehab N M, Shah, Mihir V, Ney, Blair, Copp, Janine, Stuteley, Stephanie M, Sreebhavan, Sreevalsan, Palmer, Brian, Middleditch, Martin, Tokuriki, Nobuhiko, Greening, Chris, Scott, Colin, Baker, Edward N, Jackson, Colin J

“…Cofactor F plays critical roles in primary and secondary metabolism in a range of bacteria and archaea as a low-potential hydride transfer agent. It mediates a…”
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Allosteric regulation of menaquinone (vitamin K2) biosynthesis in the human pathogen Mycobacterium tuberculosis by Bashiri, Ghader, Nigon, Laura V., Jirgis, Ehab N.M., Ho, Ngoc Anh Thu, Stanborough, Tamsyn, Dawes, Stephanie S., Baker, Edward N., Bulloch, Esther M.M., Johnston, Jodie M.

“…Menaquinone (vitamin K2) plays a vital role in energy generation and environmental adaptation in many bacteria, including the human pathogen Mycobacterium…”
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Structure and inhibition of subunit I of the anthranilate synthase complex of Mycobacterium tuberculosis and expression of the active complex by Bashiri, Ghader, Johnston, Jodie M., Evans, Genevieve L., Bulloch, Esther M. M., Goldstone, David C., Jirgis, Ehab N. M., Kleinboelting, Silke, Castell, Alina, Ramsay, Rochelle J., Manos-Turvey, Alexandra, Payne, Richard J., Lott, J. Shaun, Baker, Edward N.

“…The tryptophan‐biosynthesis pathway is essential for Mycobacterium tuberculosis (Mtb) to cause disease, but not all of the enzymes that catalyse this pathway…”
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