Search Results - "Jiracek, J"

Phosphinic acid compounds in biochemistry, biology and medicine by Collinsová, M, Jirácek, J

“…This review summarizes our knowledge of biochemical, biological and medical applications and properties of phosphinic acid compounds. Phosphinic acid compounds…”
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Synthesis of N-succinyl-L,L-diaminopimelic acid mimetics via selective protection by Vanek, V, Pícha, J, Budesínský, M, Sanda, M, Jirácek, J, Holz, R C, Hlavácek, J

“…The search for potential inhibitors that target so far unexplored bacterial enzyme mono-N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE) has stimulated…”
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OR02-5 Insulin and insulin-like growth factor II differentially regulate endocytic sorting and stability of the insulin receptor isoform A by Morrione, A, Morcavallo, A, Genua, M, Palummo, A, Kletvikova, E, Jiracek, J, Brzozowski, A.M, Iozzo, R.V, Belfiore, A

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Gene expression responses in larvae of the fleshfly Sarcophaga bullata after immune stimulation by Másová, A, Sindelka, R, Kubista, M, Kindl, J, Jirácek, J

“…Insect larvae develop in decaying organic matter and their defence against various microorganisms must therefore be highly efficient. In the present study, we…”
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Development of the First Potent and Selective Inhibitor of the Zinc Endopeptidase Neurolysin Using a Systematic Approach Based on Combinatorial Chemistry of Phosphinic Peptides by Jiráček, Jiří, Yiotakis, Athanasios, Vincent, Bruno, Checler, Frédéric, Dive, Vincent

“…A new systematic approach, based on combinatorial chemistry of phosphinic peptides, is proposed for rapid development of highly potent and selective inhibitors…”
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Theory of the correlation between capillary and free-flow zone electrophoresis and its use for the conversion of analytical capillary separations to continuous free-flow preparative processes: Application to analysis and preparation of fragments of insulin by Kašička, Václav, Prusı́k, Zdeněk, Sázelová, Petra, Jiráček, Jiřı́, Barth, Tomislav

“…A basic theoretical description of the correlation between capillary zone electrophoresis (CZE) and free-flow zone electrophoresis (FFZE) is presented. The…”
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Side reactions during photochemical cleavage of an α-methyl-6-nitroveratryl-based photolabile linker by Rinnová, M, Nováková, M, Kasicka, V, Jirácek, J

“…The mechanisms of reactions causing irreversible inhibition of the activity of enzymes when irradiated in the presence of the recently developed…”
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12389 Viral Insulin/IGF-1-like Peptides: A New Dimension In Understanding The Insulin/IGF System by Chrudinova, M, Chuard, A, Zhang, F, Dogru, Y D, De Meyts, P, Kim, J K, Kirk, N, Jiracek, J, DiMarchi, R D, Altindis, E

“…Abstract Disclosure: M. Chrudinova: None. A. Chuard: None. F. Zhang: None. Y.D. Dogru: None. P. De Meyts: None. J.K. Kim: None. N. Kirk: None. J. Jiracek:…”
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Inhibitors of N(alpha)-acetyl-L-ornithine deacetylase: synthesis, characterization and analysis of their inhibitory potency by Hlavácek, J, Pícha, J, Vanek, V, Jirácek, J, Slaninová, J, Fucík, V, Budĕsínský, M, Gilner, D, Holz, R C

“…A series of N (alpha)-acyl (alkyl)- and N (alpha)-alkoxycarbonyl-derivatives of L- and D-ornithine were prepared, characterized, and analyzed for their potency…”
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Fluids in a backthrust regime (Southern Alps, New Zealand) by UPTON, P, CALDWELL, T. G, CHAMBERLAIN, C. P, CRAW, D, JAMES, Z, JIRACEK, G. J, KOONS, P. O, WANNAMAKER, P. E

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Dissecting the Catalytic Mechanism of Betaine-Homocysteine S-Methyltransferase Using Intrinsic Tryptophan Fluorescence and Site-Directed Mutagenesis by Castro, C., Gratson, A.A., Evans, J.C., Jiracek, J., Collinsova, M., Ludwig, M.L., Garrow, T.A.

“…Betaine-homocysteine S-methyltransferase (BHMT) is a zinc-dependent enzyme that catalyzes the transfer of a methyl group from glycine betaine (Bet) to…”
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The insulin active surface problem; 3D studies on insulin analogues by Sopkova, J, Jiracek, J, Novakova, M, Svoboda, I, Jezek, J, Velek, J, Barth, T

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Betaine-Homocysteine Methyltransferase: Zinc in a Distorted Barrel by Evans, John C., Huddler, Donald P., Jiracek, Jiri, Castro, Carmen, Millian, Norman S., Garrow, Timothy A., Ludwig, Martha L.

“…Betaine-homocysteine methyl transferase (BHMT) catalyzes the synthesis of methionine from betaine and homocysteine (Hcy), utilizing a zinc ion to activate Hcy…”
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Development of Highly Potent and Selective Phosphinic Peptide Inhibitors of Zinc Endopeptidase 24-15 Using Combinatorial Chemistry (∗) by Jirácek, Jirí, Yiotakis, Athanasios, Vincent, Bruno, Lecoq, Alain, Nicolaou, Anna, Checler, Frédéric, Dive, Vincent

“…Several hundred phosphinic peptides having the general formula Z-(L,D)Pheψ(PO2CH2)(L,D)Xaa‘-Yaa‘-Zaa‘, where Xaa‘ = Gly or Ala and Yaa‘ and Zaa‘ represent 20…”
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RXP 407, a Phosphinic Peptide, Is a Potent Inhibitor of Angiotensin I Converting Enzyme Able to Differentiate between Its Two Active Sites by Dive, Vincent, Cotton, Joël, Yiotakis, Athanasios, Michaud, Annie, Vassiliou, Stamatia, Jiracek, Jiri, Vazeux, Gilles, Chauvet, Marie-Thérèse, Cuniasse, Philippe, Corvol, Pierre

“…The human somatic angiotensin converting enzyme (ACE) contains two homologous domains, each bearing a zinc-dependent active site. All of the synthetic…”
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Inhibitors of N super( alpha )-acetyl-l-ornithine deacetylase: synthesis, characterization and analysis of their inhibitory potency by Hlavacek, J, Picha, J, Vank, V, Jiracek, J, Slaninova, J, Fucik, V, Budsinsky, M, Gilner, D, Holz, R C

“…A series of N super( alpha )-acyl (alkyl)- and N super( alpha )-alkoxycarbonyl-derivatives of l- and d-ornithine were prepared, characterized, and analyzed for…”
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Physicochemical characterization of phosphinic pseudopeptides by capillary zone electrophoresis in highly acidic background electrolytes by Koval, Dušan, Kašička, Václav, Jiráček, Jiří, Collinsová, Michaela

“…Phosphinic pseudopeptides (i.e., peptide isosteres with one peptide bond replaced by a phosphinic acid moiety) were analyzed and physicochemically…”
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Shortened Insulin Analogues:  Marked Changes in Biological Activity Resulting from Replacement of TyrB26 and N-Methylation of Peptide Bonds in the C-Terminus of the B-Chain by Žáková, Lenka, Barth, Tomislav, Jiráček, Jiří, Barthová, Jana, Zórad, Štefan

“…The role of three highly conserved insulin residues PheB24, PheB25, and TyrB26 was studied to better understand the subtleties of the structure−function…”
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Dissecting the Catalytic Mechanism of Betaine−Homocysteine S-Methyltransferase by Use of Intrinsic Tryptophan Fluorescence and Site-Directed Mutagenesis by Castro, Carmen, Gratson, Alejandra A, Evans, John C, Jiracek, Jiri, Collinsová, Michaela, Ludwig, Martha L, Garrow, Timothy A

“…Betaine−homocysteine S-methyltransferase (BHMT) is a zinc-dependent enzyme that catalyzes the transfer of a methyl group from glycine betaine (Bet) to…”
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Protection of the Hydroxyphosphinyl Function of Phosphinic Dipeptides by Adamantyl. Application to the Solid-Phase Synthesis of Phosphinic Peptides by Yiotakis, Athanasios, Vassiliou, Stamatia, Jiráček, Jiří, Dive, Vincent

“…To develop solid-phase synthesis of phosphinic peptides, different FmocXaaΨ{PO(OAd)CH2}XaaOH building blocks have been prepared, where Fmoc is…”
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