Search Results - "Jinhan, He"

Immune responses in diabetic nephropathy: Pathogenic mechanisms and therapeutic target by Chen, Jiahao, Liu, Qinhui, He, Jinhan, Li, Yanping

“…Diabetic nephropathy (DN) is a chronic, inflammatory disease affecting millions of diabetic patients worldwide. DN is associated with proteinuria and…”
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The Role of Sirt6 in Obesity and Diabetes by Kuang, Jiangying, Chen, Lei, Tang, Qin, Zhang, Jinhang, Li, Yanping, He, Jinhan

“…Sirt6 is one of the sirtuin family members, a kind of NAD+-dependent histone deacetylase and ADP-ribose transferase enzyme. It has an important role in…”
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The Constitutive Androstane Receptor Is an Anti-obesity Nuclear Receptor That Improves Insulin Sensitivity by Gao, Jie, He, Jinhan, Zhai, Yonggong, Wada, Taira, Xie, Wen

“…Obesity and type 2 diabetes are related metabolic disorders of high prevalence. The constitutive androstane receptor (CAR) was initially characterized as a…”
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PEG-Derivatized Dual-Functional Nanomicelles for Improved Cancer Therapy by Li, Yanping, Zhang, Ting, Liu, Qinhui, He, Jinhan

“…Polymeric micelles have attracted considerable attention for effective delivery of poorly water-soluble cancer drugs. Polyethylene glycol (PEG), which has been…”
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Direct Effect of Glucocorticoids on Lipolysis in Adipocytes by Xu, Chong, He, Jinhan, Jiang, Hongfeng, Zu, Luxia, Zhai, Wenjie, Pu, Shenshen, Xu, Guoheng

“…Hypercortisolemia and glucocorticoid treatment cause elevated level of circulating free fatty acids (FFAs). The basis of this phenomenon has long been linked…”
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Fat-Specific Sirt6 Ablation Sensitizes Mice to High-Fat Diet-Induced Obesity and Insulin Resistance by Inhibiting Lipolysis by Kuang, Jiangying, Zhang, Yuwei, Liu, Qinhui, Shen, Jing, Pu, Shiyun, Cheng, Shihai, Chen, Lei, Li, Hong, Wu, Tong, Li, Rui, Li, Yanping, Zou, Min, Zhang, Zhiyong, Jiang, Wei, Xu, Guoheng, Qu, Aijuan, Xie, Wen, He, Jinhan

“…Sirt6 is an NAD -dependent deacetylase that is involved in the control of energy metabolism. However, the tissue-specific function of Sirt6 in the adipose…”
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Advances in the Structure of GGGGCC Repeat RNA Sequence and Its Interaction with Small Molecules and Protein Partners by Liu, Xiaole, Zhao, Xinyue, He, Jinhan, Wang, Sishi, Shen, Xinfei, Liu, Qingfeng, Wang, Shenlin

“…The aberrant expansion of GGGGCC hexanucleotide repeats within the first intron of the gene represent the predominant genetic etiology underlying amyotrophic…”
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Irisin ameliorates angiotensin II‐induced cardiomyocyte apoptosis through autophagy by Li, Ruli, Wang, Xiaoxiao, Wu, Sisi, Wu, Yao, Chen, Hongying, Xin, Juanjuan, Li, He, Lan, Jie, Xue, Kunyue, Li, Xue, Zhuo, Caili, He, Jinhan, Tang, Chao‐Shu, Jiang, Wei

“…Cardiac hypertrophy is the main cause of heart failure and sudden death in patients. But the pathogenesis is unclear. Angiotensin II may contribute to cardiac…”
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A Novel Role for the Dioxin Receptor in Fatty Acid Metabolism and Hepatic Steatosis by Lee, Jung Hoon, Wada, Taira, Febbraio, Maria, He, Jinhan, Matsubara, Tsutomu, Lee, Min Jae, Gonzalez, Frank J, Xie, Wen

“…Background & Aims The aryl hydrocarbon receptor (AhR) also known as the dioxin receptor or xenobiotic receptor is a member of the basic helix-loop-helix/period…”
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PXR Ablation Alleviates Diet-Induced and Genetic Obesity and Insulin Resistance in Mice by He, Jinhan, Gao, Jie, Xu, Meishu, Ren, Songrong, Stefanovic-Racic, Maja, O'Doherty, Robert Martin, Xie, Wen

“…The pregnane X receptor (PXR), along with its sister receptor constitutive androstane receptor (CAR), was initially characterized as a xenobiotic receptor that…”
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Targeted delivery of celastrol to renal interstitial myofibroblasts using fibronectin-binding liposomes attenuates renal fibrosis and reduces systemic toxicity by Li, Rui, Li, Yanping, Zhang, Jinhang, Liu, Qinhui, Wu, Tong, Zhou, Jian, Huang, Hui, Tang, Qin, Huang, Cuiyuan, Huang, Ya, Zhang, Zijing, Zhang, Guorong, Zhao, Yingnan, Ma, Liang, Feng, Yanhuan, Mo, Li, Han, Min, He, Jinhan

“…Renal fibrosis often occurs in chronic kidney disease, and effective treatment is needed. Celastrol (CEL) may attenuate renal fibrosis, but it distributes…”
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Novel Therapeutic Targets in Liver Fibrosis by Zhang, Jinhang, Liu, Qinhui, He, Jinhan, Li, Yanping

“…Liver fibrosis is end-stage liver disease that can be rescued. If irritation continues due to viral infection, schistosomiasis and alcoholism, liver fibrosis…”
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The emerging roles of fatty acid translocase/CD36 and the aryl hydrocarbon receptor in fatty liver disease by He, Jinhan, Lee, Jung Hoon, Febbraio, Maria, Xie, Wen

“…The fatty acid translocase (FAT)/CD36 belongs to the class B scavenger receptor family. In addition to the known functions of CD36 in the uptake of oxidized…”
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CRELD2, endoplasmic reticulum stress, and human diseases by Tang, Qin, Liu, Qinhui, Li, Yanping, Mo, Li, He, Jinhan

“…CRELD2, a member of the cysteine-rich epidermal growth factor-like domain (CRELD) protein family, is both an endoplasmic reticulum (ER)-resident protein and a…”
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Irisin Is Regulated by CAR in Liver and Is a Mediator of Hepatic Glucose and Lipid Metabolism by Mo, Li, Shen, Jing, Liu, Qinhui, Zhang, Yuwei, Kuang, Jiangying, Pu, Shiyun, Cheng, Shihai, Zou, Min, Jiang, Wei, Jiang, Changtao, Qu, Aijuan, He, Jinhan

“…Irisin, a hormone proteolytically processed from fibronectin type III domain-containing protein 5 (FNDC5), has been reported to induce the browning of sc…”
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Telmisartan attenuates obesity-induced insulin resistance via suppression of AMPK mediated ER stress by Huang, Ya, Li, Yanping, Liu, Qinhui, Zhang, Jinhang, Zhang, Zijing, Wu, Tong, Tang, Qin, Huang, Cuiyuan, Li, Rui, Zhou, Jian, Zhang, Guorong, Zhao, Yingnan, Huang, Hui, He, Jinhan

“…Telmisartan is a known angiotensin II (Ang II) AT1 receptor blocker (ARB). While the beneficial effect of Telmisartan on glucose and lipid metabolism has been…”
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Adipocyte-derived kynurenine promotes obesity and insulin resistance by activating the AhR/STAT3/IL-6 signaling by Huang, Teng, Song, Jia, Gao, Jia, Cheng, Jia, Xie, Hao, Zhang, Lu, Wang, Yu-Han, Gao, Zhichao, Wang, Yi, Wang, Xiaohui, He, Jinhan, Liu, Shiwei, Yu, Qilin, Zhang, Shu, Xiong, Fei, Zhou, Qing, Wang, Cong-Yi

“…Aberrant amino acid metabolism is a common event in obesity. Particularly, subjects with obesity are characterized by the excessive plasma kynurenine (Kyn)…”
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B3galt5 functions as a PXR target gene and regulates obesity and insulin resistance by maintaining intestinal integrity by Zhang, Jinhang, Huang, Ya, Li, Hong, Xu, Pengfei, Liu, Qinhui, Sun, Yang, Zhang, Zijing, Wu, Tong, Tang, Qin, Jia, Qingyi, Xia, Yan, Xu, Ying, Jing, Xiandan, Li, Jiahui, Mo, Li, Xie, Wen, Qu, Aijuan, He, Jinhan, Li, Yanping

“…Pregnane X receptor (PXR) has been reported to regulate glycolipid metabolism. The dysfunction of intestinal barrier contributes to metabolic disorders…”
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The diabetes medication canagliflozin promotes mitochondrial remodelling of adipocyte via the AMPK-Sirt1-Pgc-1α signalling pathway by Yang, Xuping, Liu, Qinhui, Li, Yanping, Tang, Qin, Wu, Tong, Chen, Lei, Pu, Shiyun, Zhao, Yingnan, Zhang, Guorong, Huang, Cuiyuan, Zhang, Jinhang, Zhang, Zijing, Huang, Ya, Zou, Min, Shi, Xiongjie, Jiang, Wei, Wang, Rui, He, Jinhan

“…The diabetes medication canagliflozin (Cana) is a sodium glucose cotransporter 2 (SGLT2) inhibitor acting by increasing urinary glucose excretion and thus…”
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Activation of the Aryl Hydrocarbon Receptor Sensitizes Mice to Nonalcoholic Steatohepatitis by Deactivating Mitochondrial Sirtuin Deacetylase Sirt3 by He, Jinhan, Hu, Bingfang, Shi, Xiongjie, Weidert, Eric R., Lu, Peipei, Xu, Meishu, Huang, Min, Kelley, Eric E., Xie, Wen

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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