Search Results - "Jingushi, Kentaro"

AlkB homolog 3-mediated tRNA demethylation promotes protein synthesis in cancer cells by Ueda, Yuko, Ooshio, Ikumi, Fusamae, Yasuyuki, Kitae, Kaori, Kawaguchi, Megumi, Jingushi, Kentaro, Hase, Hiroaki, Harada, Kazuo, Hirata, Kazumasa, Tsujikawa, Kazutake

“…The mammalian AlkB homolog (ALKBH) family of proteins possess a 2-oxoglutarate- and Fe(II)-dependent oxygenase domain. A similar domain in the Escherichia coli…”
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Proteomic analysis of urinary and tissue‐exudative extracellular vesicles to discover novel bladder cancer biomarkers by Tomiyama, Eisuke, Matsuzaki, Kyosuke, Fujita, Kazutoshi, Shiromizu, Takashi, Narumi, Ryohei, Jingushi, Kentaro, Koh, Yoko, Matsushita, Makoto, Nakano, Kosuke, Hayashi, Yujiro, Wang, Cong, Ishizuya, Yu, Kato, Taigo, Hatano, Koji, Kawashima, Atsunari, Ujike, Takeshi, Uemura, Motohide, Takao, Tetsuya, Adachi, Jun, Tomonaga, Takeshi, Nonomura, Norio

“…Proteomic analysis of urinary extracellular vesicles (EVs) is a powerful approach to discover potential bladder cancer (BCa) biomarkers, however urine contains…”
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Gut Microbiota-Derived Short-Chain Fatty Acids Promote Prostate Cancer Growth via IGF1 Signaling by Matsushita, Makoto, Fujita, Kazutoshi, Hayashi, Takuji, Kayama, Hisako, Motooka, Daisuke, Hase, Hiroaki, Jingushi, Kentaro, Yamamichi, Gaku, Yumiba, Satoru, Tomiyama, Eisuke, Koh, Yoko, Hayashi, Yujiro, Nakano, Kosuke, Wang, Cong, Ishizuya, Yu, Kato, Taigo, Hatano, Koji, Kawashima, Atsunari, Ujike, Takeshi, Uemura, Motohide, Imamura, Ryoichi, Rodriguez Pena, Maria D C, Gordetsky, Jennifer B, Netto, George J, Tsujikawa, Kazutake, Nakamura, Shota, Takeda, Kiyoshi, Nonomura, Norio

“…Excessive intake of animal fat and resultant obesity are major risk factors for prostate cancer. Because the composition of the gut microbiota is known to…”
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Clinical significance of the mutational landscape and fragmentation of circulating tumor DNA in renal cell carcinoma by Yamamoto, Yoshiyuki, Uemura, Motohide, Fujita, Masashi, Maejima, Kazuhiro, Koh, Yoko, Matsushita, Makoto, Nakano, Kosuke, Hayashi, Yujiro, Wang, Cong, Ishizuya, Yu, Kinouchi, Toshiro, Hayashi, Takuji, Matsuzaki, Kyosuke, Jingushi, Kentaro, Kato, Taigo, Kawashima, Atsunari, Ujike, Takeshi, Nagahara, Akira, Fujita, Kazutoshi, Imamura, Ryoichi, Nakagawa, Hidewaki, Nonomura, Norio

“…Reliable biomarkers for renal cell carcinoma (RCC) have yet to be determined. Circulating tumor DNA (ctDNA) is an emerging resource to detect and monitor…”
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Diagnostic potential of TERT promoter and FGFR3 mutations in urinary cell‐free DNA in upper tract urothelial carcinoma by Hayashi, Yujiro, Fujita, Kazutoshi, Matsuzaki, Kyosuke, Matsushita, Makoto, Kawamura, Norihiko, Koh, Yoko, Nakano, Kosuke, Wang, Cong, Ishizuya, Yu, Yamamoto, Yoshiyuki, Jingushi, Kentaro, Kato, Taigo, Kawashima, Atsunari, Ujike, Takeshi, Nagahara, Akira, Uemura, Motohide, Imamura, Ryoichi, Takao, Tetsuya, Takada, Shingo, Netto, George J, Nonomura, Norio

“…Most upper tract urothelial carcinomas (UTUC) are muscle invasive at the time of diagnosis. Current standard methods for the diagnosis of UTUC are invasive…”
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The miR-130 family promotes cell migration and invasion in bladder cancer through FAK and Akt phosphorylation by regulating PTEN by Egawa, Hiroshi, Jingushi, Kentaro, Hirono, Takayuki, Ueda, Yuko, Kitae, Kaori, Nakata, Wataru, Fujita, Kazutoshi, Uemura, Motohide, Nonomura, Norio, Tsujikawa, Kazutake

“…Bladder cancer causes an estimated 150,000 deaths per year worldwide. Although 15% of the recurrent bladder cancer becomes an invasive type, currently used…”
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High-Fat Diet-Induced Inflammation Accelerates Prostate Cancer Growth via IL6 Signaling by Hayashi, Takuji, Fujita, Kazutoshi, Nojima, Satoshi, Hayashi, Yujiro, Nakano, Kosuke, Ishizuya, Yu, Wang, Cong, Yamamoto, Yoshiyuki, Kinouchi, Toshiro, Matsuzaki, Kyosuke, Jingushi, Kentaro, Kato, Taigo, Kawashima, Atsunari, Nagahara, Akira, Ujike, Takeshi, Uemura, Motohide, Pena, Maria Del Carmen Rodriguez, Gordetsky, Jennifer B, Morii, Eiichi, Tsujikawa, Kazutake, Netto, George J, Nonomura, Norio

“…High-fat diet (HFD) could induce prostate cancer progression. The aim of this study is to identify mechanisms of HFD-induced prostate cancer progression,…”
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Extracellular vesicles isolated from human renal cell carcinoma tissues disrupt vascular endothelial cell morphology via azurocidin by Jingushi, Kentaro, Uemura, Motohide, Ohnishi, Naomi, Nakata, Wataru, Fujita, Kazutoshi, Naito, Takuya, Fujii, Risa, Saichi, Naomi, Nonomura, Norio, Tsujikawa, Kazutake, Ueda, Koji

“…Cancer‐associated extracellular vesicles (EVs) are intimately involved in establishment of tumor microenvironment and occurrence of metastasis. However,…”
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MicroRNA-130b functions as an oncomiRNA in non-small cell lung cancer by targeting tissue inhibitor of metalloproteinase-2 by Hirono, Takayuki, Jingushi, Kentaro, Nagata, Toshiyuki, Sato, Masami, Minami, Kentaro, Aoki, Masaya, Takeda, Aya Harada, Umehara, Tadashi, Egawa, Hiroshi, Nakatsuji, Yoshino, Kitae, Kaori, Ueda, Yuko, Hase, Hiroaki, Yamamoto, Masatatsu, Shinsato, Yoshinari, Kawahara, Kohichi, Furukawa, Tatsuhiko, Tsujikawa, Kazutake

“…Non-small cell lung cancer (NSCLC) is the most frequent cause of cancer-related death worldwide. Although many molecular-targeted drugs for NSCLC have been…”
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MiR-21-5p in urinary extracellular vesicles is a novel biomarker of urothelial carcinoma by Matsuzaki, Kyosuke, Fujita, Kazutoshi, Jingushi, Kentaro, Kawashima, Atsunari, Ujike, Takeshi, Nagahara, Akira, Ueda, Yuko, Tanigawa, Go, Yoshioka, Iwao, Ueda, Koji, Hanayama, Rikinari, Uemura, Motohide, Miyagawa, Yasushi, Tsujikawa, Kazutake, Nonomura, Norio

“…Extracellular vesicles are lipid bilayer vesicles containing protein, messengerRNA and microRNA. Cancer cell-derived extracellular vesicles may be diagnostic…”
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ALKBH4 promotes tumourigenesis with a poor prognosis in non-small-cell lung cancer by Jingushi, Kentaro, Aoki, Masaya, Ueda, Kazuhiro, Kogaki, Takahiro, Tanimoto, Masaya, Monoe, Yuya, Ando, Masayuki, Matsumoto, Takuya, Minami, Kentaro, Ueda, Yuko, Kitae, Kaori, Hase, Hiroaki, Nagata, Toshiyuki, Harada-Takeda, Aya, Yamamoto, Masatatsu, Kawahara, Kohichi, Tabata, Kazuhiro, Furukawa, Tatsuhiko, Sato, Masami, Tsujikawa, Kazutake

“…The human AlkB homolog family (ALKBH) of proteins play a critical role in some types of cancer. However, the expression and function of the lysine demethylase…”
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MicroRNA-130a-3p regulates osimertinib resistance by targeting runt-related transcription factor 3 in lung adenocarcinoma by Shintani, Takuya, Shun, Yu-Ting, Toyozumi, Yuji, Ikemura, Kenji, Shiroyama, Takayuki, Nagatomo, Izumi, Jingushi, Kentaro, Takeda, Yoshito, Kumanogoh, Atsushi, Okuda, Masahiro

“…Overcoming resistance to epidermal growth factor receptor tyrosine kinase inhibitors, including osimertinib, is urgent to improve lung cancer treatment…”
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Expression level of CXCL7 in peripheral blood cells is a potential biomarker for the diagnosis of renal cell carcinoma by Kinouchi, Toshiro, Uemura, Motohide, Wang, Cong, Ishizuya, Yu, Yamamoto, Yoshiyuki, Hayashi, Takuji, Matsuzaki, Kyosuke, Nakata, Wataru, Yoshida, Takahiro, Jingushi, Kentaro, Kawashima, Atsunari, Ujike, Takeshi, Nagahara, Akira, Fujita, Kazutoshi, Imamura, Ryoichi, Ueda, Yuko, Kitae, Kaori, Tsujikawa, Kazutake, Nonomura, Norio

“…There are no blood biomarkers for the diagnosis of renal cell carcinoma (RCC) in routine clinical use. We focused on the gene expression profile of peripheral…”
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Circulating extracellular vesicles carrying Firmicutes reflective of the local immune status may predict clinical response to pembrolizumab in urothelial carcinoma patients by Jingushi, Kentaro, Kawashima, Atsunari, Saito, Takuro, Kanazawa, Takayuki, Motooka, Daisuke, Kimura, Tomonori, Mita, Masashi, Yamamoto, Akinaru, Uemura, Toshihiro, Yamamichi, Gaku, Okada, Koichi, Tomiyama, Eisuke, Koh, Yoko, Matsushita, Makoto, Kato, Taigo, Hatano, Koji, Uemura, Motohide, Tsujikawa, Kazutake, Wada, Hisashi, Nonomura, Norio

“…Bacterial flora has clinical significance for the host. The metabolic environment created by this flora influences immunotherapy in urothelial carcinoma…”
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MicroRNA‐92b‐3p is a prognostic oncomiR that targets TSC1 in clear cell renal cell carcinoma by Wang, Cong, Uemura, Motohide, Tomiyama, Eisuke, Matsushita, Makoto, Koh, Yoko, Nakano, Kosuke, Hayashi, Yujiro, Ishizuya, Yu, Jingushi, Kentaro, Kato, Taigo, Hatano, Koji, Kawashima, Atsunari, Ujike, Takeshi, Nagahara, Akira, Fujita, Kazutoshi, Imamura, Ryoichi, Tsujikawa, Kazutake, Nonomura, Norio

“…Although several studies have reported that microRNA (miR)‐92b‐3p is involved in various cellular processes related to carcinogenesis, its physiological role…”
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Pharmacological Inhibition of miR-130 Family Suppresses Bladder Tumor Growth by Targeting Various Oncogenic Pathways via PTPN1 by Monoe, Yuya, Jingushi, Kentaro, Kawase, Akitaka, Hirono, Takayuki, Hirose, Ryo, Nakatsuji, Yoshino, Kitae, Kaori, Ueda, Yuko, Hase, Hiroaki, Abe, Yuichi, Adachi, Jun, Tomonaga, Takeshi, Tsujikawa, Kazutake

“…Previously, we have revealed that the miR-130 family (miR-130b, miR-301a, and miR-301b) functions as an oncomiR in bladder cancer. The pharmacological…”
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ALKBH8 promotes bladder cancer growth and progression through regulating the expression of survivin by Ohshio, Ikumi, Kawakami, Ryoji, Tsukada, Yohei, Nakajima, Kazuhiro, Kitae, Kaori, Shimanoe, Tomoki, Saigo, Yasuka, Hase, Hiroaki, Ueda, Yuko, Jingushi, Kentaro, Tsujikawa, Kazutake

“…Human AlkB homolog 8 (ALKBH8) is highly expressed in high-grade, superficially and deeply invasive bladder cancer. Moreover, ALKBH8 knockdown induces apoptosis…”
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Development of a highly sensitive method for the quantitative analysis of modified nucleosides using UHPLC-UniSpray-MS/MS by Kogaki, Takahiro, Ohshio, Ikumi, Ura, Hasumi, Iyama, Souta, Kitae, Kaori, Morie, Toshiya, Fujii, Shintarou, Sato, Shohei, Nagata, Toshiyuki, Takeda, Aya Harada, Aoki, Masaya, Ueda, Kazuhiro, Minami, Kentaro, Yamamoto, Masatatsu, Kawahara, Kohichi, Furukawa, Tatsuhiko, Sato, Masami, Ueda, Yuko, Jingushi, Kentaro, Tozuka, Zenzaburo, Saigusa, Daisuke, Hase, Hiroaki, Tsujikawa, Kazutake

“…[Display omitted] •We developed a novel method to detect modified nucleosides by combining a new ion source (UniSpray) with UHPLC-MS/MS.•UniSpray could detect…”
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Peripheral blood monocyte count reflecting tumor‐infiltrating macrophages is a predictive factor of adverse pathology in radical prostatectomy specimens by Hayashi, Takuji, Fujita, Kazutoshi, Nojima, Satoshi, Hayashi, Yujiro, Nakano, Kosuke, Ishizuya, Yu, Wang, Cong, Yamamoto, Yoshiyuki, Kinouchi, Toshiro, Matsuzaki, Kyosuke, Kawamura, Norihiko, Jingushi, Kentaro, Kawashima, Atsunari, Nagahara, Akira, Ujike, Takeshi, Uemura, Motohide, Imamura, Ryoichi, Morii, Eiichi, Nonomura, Norio

“…Background Tumor‐infiltrating macrophages, which are thought to be derived from blood monocytes, interact with tumor cells to promote cancer progression. The…”
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Increased level and fragmentation of plasma circulating cell-free DNA are diagnostic and prognostic markers for renal cell carcinoma by Yamamoto, Yoshiyuki, Uemura, Motohide, Nakano, Kosuke, Hayashi, Yujiro, Wang, Cong, Ishizuya, Yu, Kinouchi, Toshiro, Hayashi, Takuji, Matsuzaki, Kyosuke, Jingushi, Kentaro, Kato, Taigo, Kawashima, Atsunari, Ujike, Takeshi, Nagahara, Akira, Fujita, Kazutoshi, Imamura, Ryoichi, Nonomura, Norio

“…Reliable biomarkers for renal cell carcinoma (RCC) have yet to be found. Circulating cell-free DNA (cfDNA) is an emerging resource for the diagnosis and…”
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