Search Results - "Jingjun, Lyu"

Single-cell transcriptomic analysis of the immune cell landscape in the aged mouse brain after ischemic stroke by Li, Xuan, Lyu, Jingjun, Li, Ran, Jain, Vaibhav, Shen, Yuntian, Del Águila, Ángela, Hoffmann, Ulrike, Sheng, Huaxin, Yang, Wei

“…Ischemic stroke is a medical emergency that primarily affects the elderly. A complex immune response in the post-stroke brain constitutes a key component of…”
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LncRNA GAS5/miR-137 Is a Hypoxia-Responsive Axis Involved in Cardiac Arrest and Cardiopulmonary Cerebral Resuscitation by Jing, Wang, Tuxiu, Xie, Xiaobing, Long, Guijun, Jiang, Lulu, Kang, Jie, Jiang, Lu, Ye, Liying, Zhan, Xiaoxing, Xiong, Jingjun, Lyu

“…Cardiac arrest/cardiopulmonary resuscitation (CA/CPR) represents one of the devastating medical emergencies and is associated with high mortality and…”
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MCC950, a selective NLPR3 inflammasome inhibitor, improves neurologic function and survival after cardiac arrest and resuscitation by Jiang, Maorong, Li, Ran, Lyu, Jingjun, Li, Xuan, Wang, Wei, Wang, Zhuoran, Sheng, Huaxin, Zhang, Weiguo, Karhausen, Jörn, Yang, Wei

“…Abstract Background Cardiac arrest (CA) is associated with high morbidity and mortality, even after spontaneous circulation is re-established. This dire…”
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Development and Evaluation of a Novel Mouse Model of Asphyxial Cardiac Arrest Revealed Severely Impaired Lymphopoiesis After Resuscitation by Wang, Wei, Li, Ran, Miao, Wanying, Evans, Cody, Lu, Liping, Lyu, Jingjun, Li, Xuan, Warner, David S, Zhong, Xiaoping, Hoffmann, Ulrike, Sheng, Huaxin, Yang, Wei

“…Background Animal disease models represent the cornerstone in basic cardiac arrest (CA) research. However, current experimental models of CA and resuscitation…”
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The effect of tacrolimus-containing polyethylene glycol-modified maghemite nanospheres on reducing oxidative stress and accelerating the healing spinal cord injury of rats based on increasing M2 macrophages by Wang, Jing, Xie, Tuxiu, Long, Xiaobing, Gao, Rukai, Kang, Lulu, Wang, Qingyuan, Jiang, Jie, Ye, Lu, Lyu, Jingjun

“…One of the key factors in repairing spinal cord injury is reducing inflammation and oxidative stress. So, it was tried to increase the growth of neurons more…”
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IL-12p40 deletion aggravates lipopolysaccharide-induced cardiac dysfunction in mice by Liu, Menglin, Wang, Zhen, Zhang, Jishou, Ye, Di, Wang, Menglong, Xu, Yao, Zhao, Mengmeng, Feng, Yongqi, Lu, Xiyi, Pan, Heng, Pan, Wei, Wei, Cheng, Tian, Dan, Li, Wenqiang, Lyu, Jingjun, Ye, Jing, Wan, Jun

“…Background Cardiac dysfunction is one of the most common complications of sepsis and is associated with the adverse outcomes and high mortality of sepsis…”
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PERK (Protein Kinase RNA-Like ER Kinase) Branch of the Unfolded Protein Response Confers Neuroprotection in Ischemic Stroke by Suppressing Protein Synthesis by Wang, Ya-chao, Li, Xuan, Shen, Yuntian, Lyu, Jingjun, Sheng, Huaxin, Paschen, Wulf, Yang, Wei

“…BACKGROUND AND PURPOSE—Ischemic stroke impairs endoplasmic reticulum (ER) function, causes ER stress, and activates the unfolded protein response. The unfolded…”
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Cardiac arrest and resuscitation activates the hypothalamic-pituitary-adrenal axis and results in severe immunosuppression by Zhao, Qiang, Shen, Yuntian, Li, Ran, Wu, Jiangbo, Lyu, Jingjun, Jiang, Maorong, Lu, Liping, Zhu, Minghua, Wang, Wei, Wang, Zhuoran, Liu, Qiang, Hoffmann, Ulrike, Karhausen, Jörn, Sheng, Huaxin, Zhang, Weiguo, Yang, Wei

“…In patients who are successfully resuscitated after initial cardiac arrest (CA), mortality and morbidity rates are high, due to ischemia/reperfusion injury to…”
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Copper oxide nanoparticles promote α-synuclein oligomerization and underlying neurotoxicity as a model of Parkinson's disease by Lyu, Jingjun, Long, Xiaobing, Xie, Tuxiu, Jiang, Guijun, Jiang, Jie, Ye, Lu, Li, Qiongzi

“…Parkinson's disease is associated with the formation of protein aggregates called amyloid fibrils. α-synuclein amyloid accumulation is known to be a key factor…”
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Small ubiquitin‐like modifier 2 (SUMO2) is critical for memory processes in mice by Yu, Shu, Galeffi, Francesca, Rodriguiz, Ramona M., Wang, Zhuoran, Shen, Yuntian, Lyu, Jingjun, Li, Ran, Bernstock, Joshua D., Johnson, Kory R., Liu, Shuai, Sheng, Huaxin, Turner, Dennis A., Wetsel, William C., Paschen, Wulf, Yang, Wei

“…Small ubiquitin‐like modifier (SUMO1‐3) conjugation (SUMOylation), a posttranslational modification, modulates almost all major cellular processes. Mounting…”
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Neutrophil-to-lymphocyte ratio is a powerful predictor of adult patients with acute respiratory distress syndrome who might benefit from corticosteroid therapy by Wang, Qingyuan, Xie, Tuxiu, Gao, Rukai, Long, Xiaobing, Wei, Jie, Ye, Lu, Jiang, Jie, Kang, Lulu, Wang, Jing, Jun, Chen, Lyu, Jingjun

“…BACKGROUNDThere is no convincing pharmacological treatment for patients withacute respiratory distress syndrome (ARDS). The efficacy of corticosteroids in ARDS…”
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