Search Results - "Jing, Xuping"
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Stringent control of the RNA-dependent RNA polymerase translocation revealed by multiple intermediate structures
Published in Nature communications (25-05-2020)“…Each polymerase nucleotide addition cycle is associated with two primary conformational changes of the catalytic complex: the pre-chemistry active site closure…”
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Crystal structure of Bacillus thuringiensis Cry7Ca1 toxin active against Locusta migratoria manilensis
Published in Protein science (01-03-2019)“…Insecticidal crystal (Cry) proteins produced by Bacillus thuringiensis (Bt) are widely used as environmentally friendly insecticides. As the only known Cry…”
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Crystal structure of a tick-borne flavivirus RNA-dependent RNA polymerase suggests a host adaptation hotspot in RNA viruses
Published in Nucleic acids research (22-02-2021)“…The RNA-dependent RNA polymerases (RdRPs) encoded by RNA viruses represent a unique class of nucleic acid polymerases. RdRPs are essential in virus life cycle…”
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The two-stage interaction of Ebola virus VP40 with nucleoprotein results in a switch from viral RNA synthesis to virion assembly/budding
Published in Protein & cell (01-02-2022)“…Ebola virus (EBOV) is an enveloped negative-sense RNA virus and a member of the filovirus family. Nucleoprotein (NP) expression alone leads to the formation of…”
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A jingmenvirus RNA-dependent RNA polymerase structurally resembles the flavivirus counterpart but with different features at the initiation phase
Published in Nucleic acids research (12-04-2024)“…Jingmenviruses are a category of emerging segmented viruses that have garnered global attention in recent years, and are close relatives of the flaviviruses in…”
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Cataract-causing Y204X mutation of crystallin protein CRYβB1 promotes its C-terminal degradation and higher-order oligomerization
Published in The Journal of biological chemistry (01-08-2023)“…Crystallin proteins are a class of main structural proteins of the vertebrate eye lens, and their solubility and stability directly determine transparency and…”
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Crystallographic Snapshots of the Zika Virus NS3 Helicase Help Visualize the Reactant Water Replenishment
Published in ACS infectious diseases (08-02-2019)“…Zika virus (ZIKV), a positive-strand RNA virus belonging to the Flavivirus genus, has become an urgent public health concern since recent outbreaks worldwide…”
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