Search Results - "Jing, Ruirui"
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Engineering Cytoplasmic Signaling of CD28ζ CARs for Improved Therapeutic Functions
Published in Frontiers in immunology (19-06-2020)“…Chimeric antigen receptor modified T cells (CAR-T) have yielded impressive clinical outcomes in treating hematopoietic malignancies. However, relapses have…”
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Sequential CD7 CAR T-Cell Therapy and Allogeneic HSCT without GVHD Prophylaxis
Published in The New England journal of medicine (25-04-2024)“…Of 10 patients with relapsed or refractory hematologic cancers who received sequential CAR T-cell infusion followed by allogeneic stem-cell transplantation…”
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Recognition of Key Information in Non-Stationary Signals Based on Wavelet Threshold Denoising and Back Propagation Neural Network Optimized by Manta Ray Foraging Optimization Algorithm
Published in IEEE access (2022)“…The identification of key information hidden in non-stationary signals is challenging in various fields such as logistics and transportation, biomedicine, and…”
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Relapsed/Refractory Peripheral T-Cell Lymphoma-Associated Hemophagocytic Lymphohistiocytosis With UNC13D and CD27 Germline Mutations
Published in Cell transplantation (01-01-2024)“…Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory disease characterized by familial and acquired forms. Here, we present the case of a…”
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CRISPR/Cas-based CAR-T cells: production and application
Published in Biomarker research (31-05-2024)“…Chimeric antigen receptor T cell (CAR-T) therapy has revolutionized the treatment approach for cancer, autoimmune disease, and heart disease. The integration…”
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Incidence, clinical characteristics and prognosis of tumor lysis syndrome following B-cell maturation antigen-targeted chimeric antigen receptor-T cell therapy in relapsed/refractory multiple myeloma
Published in Frontiers in immunology (04-05-2023)“…B-cell maturation antigen (BCMA)-targeted chimeric antigen receptor-T cell (CAR-T) therapy is used for refractory or relapsed multiple myeloma (r/r MM)…”
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Correction: CRISPR/Cas-based CAR-T cells: production and application
Published in Biomarker research (23-07-2024)Get full text
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Unraveling Molecular Differences of Gastric Cancer by Label-Free Quantitative Proteomics Analysis
Published in International journal of molecular sciences (01-01-2016)“…Gastric cancer (GC) has significant morbidity and mortality worldwide and especially in China. Its molecular pathogenesis has not been thoroughly elaborated…”
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LC-MS/MS Analysis Unravels Deep Oxidation of Manganese Superoxide Dismutase in Kidney Cancer
Published in International journal of molecular sciences (04-02-2017)“…Manganese superoxide dismutase (MNSOD) is one of the major scavengers of reactive oxygen species (ROS) in mitochondria with pivotal regulatory role in ischemic…”
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Treatment of allergic eosinophilic asthma through engineered IL-5-anchored chimeric antigen receptor T cells
Published in Cell discovery (16-08-2022)“…Severe eosinophilic asthma (SEA) is a therapy-resistant respiratory condition with poor clinical control. Treatment efficacy and patient compliance of current…”
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Label-Free Quantitative Proteomics Unravels Carboxypeptidases as the Novel Biomarker in Pancreatic Ductal Adenocarcinoma
Published in Translational oncology (01-06-2018)“…Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers, with a high mortality rate and poor prognosis. However, little is known concerning…”
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Post-Translational Modification of Human Histone by Wide Tolerance of Acetylation
Published in Cells (Basel, Switzerland) (12-10-2017)“…Histone acetylation adds an acetyl group on the lysine residue commonly found within the N-terminal tail protruding from the histone core of the nucleosome,…”
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H2A/K pseudogene mutation may promote cell proliferation
Published in Mutation research (01-05-2016)“…Little attention has been paid to the histone H2A/K pseudogene. Results from our laboratory showed that 7 of 10 kidney cancer patients carried a mutant H2A/K…”
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Effects of music therapy on cancer-related fatigue, anxiety, and depression in patients with digestive tumors: A protocol for systematic review and meta-analysis
Published in Medicine (Baltimore) (04-06-2021)“…Digestive tumor is one of the most common cancers, its symptoms and treatment will bring patients with anxiety, depression and other negative emotions, and…”
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Multiple Signaling Roles of CD3ε and Its Application in CAR-T Cell Therapy
Published in Cell (20-08-2020)“…A T cell receptor (TCR) mediates antigen-induced signaling through its associated CD3ε, δ, γ, and ζ, but the contributions of different CD3 chains remain…”
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Mitochondrial isocitrate dehydrogenase impedes CAR T cell function by restraining antioxidant metabolism and histone acetylation
Published in Cell metabolism (02-01-2024)“…The efficacy of chimeric antigen receptor (CAR) T cell therapy is hampered by relapse in hematologic malignancies and by hyporesponsiveness in solid tumors…”
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Exploiting Ca2+ signaling in T cells to advance cancer immunotherapy
Published in Seminars in immunology (01-06-2020)“…Decades of basic research has established the importance of Ca2+ to various T cell functions, such as cytotoxicity, proliferation, differentiation and cytokine…”
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HBV reactivation in patients with chronic or resolved HBV infection following BCMA-targeted CAR-T cell therapy
Published in Bone marrow transplantation (Basingstoke) (01-06-2023)“…B-cell maturation antigen (BCMA)-targeted chimeric antigen receptor-T cell (CAR-T) therapy is used for refractory or relapsed multiple myeloma (r/r MM)…”
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Neither Conditioning Chemotherapy Nor GvHD-Prophylaxis: CD7 CAR-T Treatment Bridging to Haplo-HSCT
Published in Blood (02-11-2023)“…BACKGROUND: Relapsed/refractory (R/R) acute leukemia patients ineligible for allo-HSCT have poor prognosis. CAR-T therapy has shown promising therapeutic…”
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