Search Results - "Jing, Qiong"

Epileptic Mechanisms Shared by Alzheimer’s Disease: Viewed via the Unique Lens of Genetic Epilepsy by Kang, Jing-Qiong

“…Our recent work on genetic epilepsy (GE) has identified common mechanisms between GE and neurodegenerative diseases including Alzheimer’s disease (AD)…”
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Defects at the crossroads of GABAergic signaling in generalized genetic epilepsies by Kang, Jing-Qiong

“…•Impaired GABAergic signaling is a converging pathway for epilepsies associated with mutations in several unrelated genes.•GABAergic signaling could be…”
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Ongoing Pharmacological Developments in SLC6A1 Research & Treatment by DeLeeuw, Melissa B., Tiller, Jacob, Kang, Jing‐Qiong, Freed, Amber

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Mutations in GABAA receptor subunits associated with genetic epilepsies by Macdonald, Robert L., Kang, Jing‐Qiong, Gallagher, Martin J.

“…Mutations in inhibitory GABAA receptor subunit genes (GABRA1, GABRB3, GABRG2 and GABRD) have been associated with genetic epilepsy syndromes including…”
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Heterozygous GABAA receptor β3 subunit N110D knock‐in mice have epileptic spasms by Qu, Shimian, Jackson, Laurel G., Zhou, Chengwen, Shen, DingDing, Shen, Wangzhen, Nwosu, Gerald, Howe, Rachel, Catron, Mackenzie A., Flamm, Carson, Biven, Marshall, Kang, Jing‐Qiong, Macdonald, Robert L.

“…Objective Infantile spasms is an epileptic encephalopathy of childhood, and its pathophysiology is largely unknown. We generated a heterozygous knock‐in mouse…”
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Distinct roles of GRIN2A and GRIN2B variants in neurological conditions [version 1; peer review: awaiting peer review] by Myers, Scott J, Yuan, Hongjie, Kang, Jing-Qiong, Tan, Francis Chee Kuan, Traynelis, Stephen F, Low, Chian-Ming

“…Rapid advances in sequencing technology have led to an explosive increase in the number of genetic variants identified in patients with neurological disease…”
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Layered Birnessite Cathode with a Displacement/Intercalation Mechanism for High-Performance Aqueous Zinc-Ion Batteries by Zhai, Xian-Zhi, Qu, Jin, Hao, Shu-Meng, Jing, Ya-Qiong, Chang, Wei, Wang, Juan, Li, Wei, Abdelkrim, Yasmine, Yuan, Hongfu, Yu, Zhong-Zhen

“…Highlights A layered sodium-ion/crystal water co-intercalated Na 0.55 Mn 2 O 4 ·0.57H 2 O (NMOH) cathode is synthesized successfully with a selectively etching…”
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The human epilepsy mutation GABRG2(Q390X) causes chronic subunit accumulation and neurodegeneration by Kang, Jing-Qiong, Shen, Wangzhen, Zhou, Chengwen, Xu, Dong, Macdonald, Robert L

“…The Q390X mutation in the GABA A receptor GABRG2 has been associated with Dravet syndrome in humans. In this study, the authors generated a new genetic…”
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Genetic mosaicism, intrafamilial phenotypic heterogeneity, and molecular defects of a novel missense SLC6A1 mutation associated with epilepsy and ADHD by Poliquin, Sarah, Hughes, Inna, Shen, Wangzhen, Mermer, Felicia, Wang, Juexin, Mack, Taralynn, Xu, Dong, Kang, Jing-Qiong

“…Mutations in SLC6A1, encoding γ-aminobutyric acid (GABA) transporter 1 (GAT-1), have been recently associated with a spectrum of neurodevelopmental disorders…”
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4‐Phenylbutyrate promoted wild‐type γ‐aminobutyric acid type A receptor trafficking, reduced endoplasmic reticulum stress, and mitigated seizures in Gabrg2+/Q390X mice associated with Dravet syndrome by Shen, Wangzhen, Flamm, Carson, Delahanty, Aiden J., Casteel, Emmett, Biven, Marshall, DeLeeuw, Melissa B., Poliquin, Sarah, Nwosu, Gerald, Randhave, Karishma, Kang, Jing‐Qiong

“…Objective γ‐Aminobutyric acid type A (GABAA) receptor subunit gene mutations are major causes of various epilepsy syndromes, including severe kinds such as…”
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Common molecular mechanisms of SLC6A1 variant-mediated neurodevelopmental disorders in astrocytes and neurons by Mermer, Felicia, Poliquin, Sarah, Rigsby, Kathryn, Rastogi, Anuj, Shen, Wangzhen, Romero-Morales, Alejandra, Nwosu, Gerald, McGrath, Patrick, Demerast, Scott, Aoto, Jason, Bilousova, Ganna, Lal, Dennis, Gama, Vivian, Kang, Jing-Qiong

“…Solute carrier family 6 member 1 (SLC6A1) is abundantly expressed in the developing brain even before the CNS is formed. Its encoded GABA transporter 1 (GAT-1)…”
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MG53 ameliorates nerve injury induced neuropathic pain through the regulation of Nrf2/HO-1 signaling in rats by Zhu, Xuan-Zhi, Wang, Jing-Qiong, Wu, Yao-Hua

“…Neuropathic pain is one of the most common types of chronic pain, and it arises as a direct consequence of a lesion or disease that affects the somatosensory…”
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Astrocytic GABA transporter 1 deficit in novel SLC6A1 variants mediated epilepsy: Connected from protein destabilization to seizures in mice and humans by Mermer, Felicia, Poliquin, Sarah, Zhou, Shuizhen, Wang, Xiaodong, Ding, Yifeng, Yin, Fei, Shen, Wangzhen, Wang, Juexin, Rigsby, Kathryn, Xu, Dong, Mack, Taralynn, Nwosu, Gerald, Flamm, Carson, Stein, Matthew, Kang, Jing-Qiong

“…Mutations in γ-aminobutyric acid (GABA) transporter 1 (GAT-1)-encoding SLC6A1 have been associated with myoclonic atonic epilepsy and other phenotypes. We…”
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Disruption of the Ubiquitin-Proteasome System and Elevated Endoplasmic Reticulum Stress in Epilepsy by Poliquin, Sarah, Kang, Jing-Qiong

“…The epilepsies are a broad group of conditions characterized by repeated seizures, and together are one of the most common neurological disorders…”
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Modulating Endoplasmic Reticulum Chaperones and Mutant Protein Degradation in GABRG2(Q390X) Associated with Genetic Epilepsy with Febrile Seizures Plus and Dravet Syndrome by Poliquin, Sarah, Nwosu, Gerald, Randhave, Karishma, Shen, Wangzhen, Flamm, Carson, Kang, Jing-Qiong

“…A significant number of patients with genetic epilepsy do not obtain seizure freedom, despite developments in new antiseizure drugs, suggesting a need for…”
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Molecular basis for and chemogenetic modulation of comorbidities in GABRG2‐deficient epilepsies by Zhang, Chun‐Qing, McMahon, Bryan, Dong, Huancheng, Warner, Timothy, Shen, Wangzhen, Gallagher, Martin, Macdonald, Robert L., Kang, Jing‐Qiong

“…Objective γ‐Aminobutyric acid type A (GABAA) receptor subunit gene mutations are significant causes of epilepsy, which are often accompanied by various…”
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Trafficking-deficient mutant GABRG2 subunit amount may modify epilepsy phenotype by Kang, Jing-Qiong, Shen, Wangzhen, Macdonald, Robert L.

“…Objective Genetic epilepsies and many other human genetic diseases display phenotypic heterogeneity, often for unknown reasons. Disease severity associated…”
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Insights into the similarities and differences of whiteleg shrimp pre-soaked with sodium tripolyphosphate and sodium trimetaphosphate during frozen storage by Ying, Xiao-guo, Wu, Qiong-jing, Shui, Shan-shan, Zhang, Bin, Benjakul, Soottawat

“…•Similarities and differences in shrimp pre-soaked with STPP and STMP were investigated during storage.•STMP and STPP maintained the WHC, texture, and thermal…”
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Variable Expression of GABAA Receptor Subunit Gamma 2 Mutation in a Nuclear Family Displaying Developmental and Encephalopathic Phenotype by Nwosu, Gerald, Reddy, Shilpa B, Riordan, Heather Rose Mead, Kang, Jing-Qiong

“…Mutations in GABA receptor subunit genes ( ) are a major etiology for developmental and epileptic encephalopathies (DEEs). This article reports a case of a…”
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Endoplasmic reticulum stress increases inflammatory cytokines in an epilepsy mouse model Gabrg2+/Q390X knockin: A link between genetic and acquired epilepsy? by Shen, Wangzhen, Poliquin, Sarah, Macdonald, Robert L., Dong, Marco, Kang, Jing‐Qiong

“…Objective Neuroinflammation is a major theme in epilepsy, which has been characterized in acquired epilepsy but is poorly understood in genetic epilepsy…”
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