Search Results - "Jindra, P. T."
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Tolerance to MHC class II disparate allografts through genetic modification of bone marrow
Published in Gene therapy (01-05-2013)“…Induction of molecular chimerism through genetic modification of bone marrow is a powerful tool for the induction of tolerance. Here, we demonstrate for the…”
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Phosphorylated S6 Ribosomal Protein: A Novel Biomarker of Antibody‐Mediated Rejection in Heart Allografts
Published in American journal of transplantation (01-07-2006)“…We tested the hypothesis that phosphorylation of S6 ribosomal protein (S6RP), a downstream target of the PI3K/Akt/mTOR pathway, is a biomarker of…”
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Anti-HLA class I antibody–mediated activation of the PI3K/Akt signaling pathway and induction of Bcl-2 and Bcl-xL expression in endothelial cells
Published in Human immunology (01-04-2004)“…Anti–human leukocyte antigen (HLA) antibodies (Ab) have long been implicated in the process of acute and chronic allograft rejection, yet their mechanism(s) of…”
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Sequence Selective Recognition in the Minor Groove of dsDNA by Pyrrole, Imidazole-Substituted Bis-benzimidazole Conjugates
Published in Journal of the American Chemical Society (02-07-2003)“…A series of pyrrole, imidazole-substituted bis-benzimidazole conjugates, Py-Py-Im-γ-biBenz, Py-Py-γ-biBenz, Py-Im-γ-biBenz, and Im-Py-γ-biBenz (1−4), were…”
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Glomerular mRNA Expression of Prothrombotic and Antithrombotic Factors in Renal Transplants With Thrombotic Microangiopathy
Published in Transplantation (27-05-2013)“…BACKGROUNDThrombotic microangiopathy (TMA) in renal transplants (rTx-TMA) is a serious complication and is usually either recurrent TMA (RecTMA) due to humoral…”
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Anti-HLA antibodies can induce endothelial cell survival or proliferation depending on their concentration
Published in Transplantation (15-07-2006)“…Patients exhibiting a humoral immune response to the transplanted organ are at increased risk of antibody-mediated rejection and development of transplant…”
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Conference Proceeding Journal Article -
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MHC class I and integrin ligation induce ERK activation via an mTORC2-dependent pathway
Published in Biochemical and biophysical research communications (02-05-2008)“…The aim of this study was to characterize the interaction between mTOR and ERK in primary endothelial cells (EC) following MHC class I and integrin ligation…”
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Anti-HLA class I antibodies activate endothelial cells and promote chronic rejection
Published in Transplantation (15-02-2005)“…Transplant recipients exhibiting a humoral immune response to the allograft demonstrate lower graft survival and increased risk for the development of chronic…”
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Conference Proceeding Journal Article