Search Results - "Jin-il Kim"
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Vitamin D-binding protein-loaded PLGA nanoparticles suppress Alzheimer's disease-related pathology in 5XFAD mice
Published in Nanomedicine (01-04-2019)“…The aggregation and accumulation of amyloid beta (Aβ) peptide is believed to be the primary cause of Alzheimer's disease (AD) pathogenesis. Vitamin D-binding…”
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2
Targeting KRAS4A splicing through the RBM39/DCAF15 pathway inhibits cancer stem cells
Published in Nature communications (13-07-2021)“…The commonly mutated human KRAS oncogene encodes two distinct KRAS4A and KRAS4B proteins generated by differential splicing. We demonstrate here that…”
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3
FBXW7 Targets mTOR for Degradation and Cooperates with PTEN in Tumor Suppression
Published in Science (American Association for the Advancement of Science) (12-09-2008)“…The enzyme mTOR (mammalian target of rapamycin) is a major target for therapeutic intervention to treat many human diseases, including cancer, but very little…”
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Omega-3 Fatty Acid-Type Docosahexaenoic Acid Protects against Aβ-Mediated Mitochondrial Deficits and Pathomechanisms in Alzheimer's Disease-Related Animal Model
Published in International journal of molecular sciences (29-05-2020)“…It has been reported that damage to the mitochondria affects the progression of Alzheimer's disease (AD), and that mitochondrial dysfunction is improved by…”
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5
Tailoring the refractive index and surface defects of CsPbBr3 quantum dots via alkyl cation-engineering for efficient perovskite light-emitting diodes
Published in Chemical engineering journal (Lausanne, Switzerland : 1996) (01-12-2021)“…Short-chained, aromatic phenethylammonium bromide (PEABr) bulky cation engineering mitigate the surface defects and tune the optical refractive index (n) and…”
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6
Ghrelin in Alzheimer's disease: Pathologic roles and therapeutic implications
Published in Ageing research reviews (01-11-2019)“…Ghrelin, which has many important physiological roles, such as stimulating food intake, regulating energy homeostasis, and releasing insulin, has recently been…”
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Red Ginseng Attenuates Aβ-Induced Mitochondrial Dysfunction and Aβ-mediated Pathology in an Animal Model of Alzheimer's Disease
Published in International journal of molecular sciences (21-06-2019)“…Alzheimer's disease (AD) is the most common neurodegenerative disease and is characterized by neurodegeneration and cognitive deficits. Amyloid beta (Aβ)…”
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Preparation and characterization of thermoresponsive poly(N‐isopropylacrylamide‐co‐N‐isopropylmethacrylamide) hydrogel materials for smart windows
Published in Journal of applied polymer science (10-02-2021)“…In this study, a series of thermoresponsive cross‐linked copolymer poly [N‐isopropylacrylamide(NIPAm)‐co‐N‐isopropylmethacrylamide(NIPMAm)] (P‐M series…”
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9
Inhibition of CK2α down-regulates Hedgehog/Gli signaling leading to a reduction of a stem-like side population in human lung cancer cells
Published in PloS one (29-06-2012)“…Protein kinase CK2 is frequently elevated in a variety of human cancers. The Hedgehog (Hh) signaling pathway has been implicated in stem cell maintenance, and…”
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Pharmacological Stimulation of Nurr1 Promotes Cell Cycle Progression in Adult Hippocampal Neural Stem Cells
Published in International journal of molecular sciences (18-12-2019)“…Nuclear receptor related-1 (Nurr1) protein performs a crucial role in hippocampal neural stem cell (hNSC) development as well as cognitive functions. We…”
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Systematic comparison of two whole-genome amplification methods for targeted next-generation sequencing using frozen and FFPE normal and cancer tissues
Published in Scientific reports (22-06-2017)“…Sequencing key cancer-driver genes using formalin-fixed, paraffin-embedded (FFPE) cancer tissues is becoming the standard for identifying the best treatment…”
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12
A mouse xenograft long‐term replication yields a SARS‐CoV‐2 Delta mutant with increased lethality
Published in Journal of medical virology (01-02-2024)“…We recently established a long‐term SARS‐CoV‐2 infection model using lung‐cancer xenograft mice and identified mutations that arose in the SARS‐CoV‐2 genome…”
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13
Synthesis of Pd or Pt/titanate nanotube and its application to catalytic type hydrogen gas sensor
Published in Sensors and actuators. B, Chemical (12-12-2007)“…A catalytic combustible gas sensor has been developed by using Pd and Pt/titanate nanotubes. Pd and Pt/titanate nanotube catalysts were synthesized by a…”
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14
Concomitant therapy achieved the best eradication rate for Helicobacter pylori among various treatment strategies
Published in World journal of gastroenterology : WJG (07-01-2015)“…AIM: To compare the Helicobacter pylori(H.pylori) eradication rate of clarithromycin-based triple therapy,metronidazole-based triple therapy,sequential therapy…”
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15
Gremlin is overexpressed in lung adenocarcinoma and increases cell growth and proliferation in normal lung cells
Published in PloS one (01-08-2012)“…Gremlin, a member of the Dan family of BMP antagonists, is a glycosylated extracellular protein. Previously Gremlin has been shown to play a role in…”
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Empirical Therapy Versus Tailored Therapy of Helicobacter pylori in Korea: Results of the K‐CREATE Study
Published in Helicobacter (Cambridge, Mass.) (01-07-2024)“…ABSTRACT Background The optimal duration of regimens for tailored therapy based on genotypic resistance for clarithromycin has yet to be established. Aim This…”
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Triple Therapy-Based on Tegoprazan, a New Potassium-Competitive Acid Blocker, for First-Line Treatment of Helicobacter pylori Infection: A Randomized, Double-Blind, Phase III, Clinical Trial
Published in Gut and liver (06-07-2022)“…Background/AimsWe examined the efficacy and safety of tegoprazan as a part of first-line triple therapy for Helicobacter pylori eradication. MethodsA…”
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The Potential Roles of Ghrelin in Metabolic Syndrome and Secondary Symptoms of Alzheimer’s Disease
Published in Frontiers in neuroscience (24-09-2020)“…Although the major causative factors of Alzheimer’s disease (AD) are the accumulation of amyloid beta and hyperphosphorylated tau, AD can also be caused by…”
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Adaptive mutations of neuraminidase stalk truncation and deglycosylation confer enhanced pathogenicity of influenza A viruses
Published in Scientific reports (07-09-2017)“…It has been noticed that neuraminidase (NA) stalk truncation has arisen from evolutionary adaptation of avian influenza A viruses (IAVs) from wild aquatic…”
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Jowiseungchungtang Inhibits Amyloid-β Aggregation and Amyloid-β-Mediated Pathology in 5XFAD Mice
Published in International journal of molecular sciences (13-12-2018)“…Alzheimer's disease (AD) is a neurodegenerative disease, which is accompanied by memory loss and cognitive dysfunction. Although a number of trials to treat AD…”
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