Search Results - "Jin Guoxiang"

Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS by Zhang, Weina, Wang, Guihua, Xu, Zhi-Gang, Tu, Haiqing, Hu, Fuqing, Dai, Jiang, Chang, Yan, Chen, Yaqi, Lu, Yanjun, Zeng, Haolong, Cai, Zhen, Han, Fei, Xu, Chuan, Jin, Guoxiang, Sun, Li, Pan, Bo-Syong, Lai, Shiue-Wei, Hsu, Che-Chia, Xu, Jia, Chen, Zhong-Zhu, Li, Hong-Yu, Seth, Pankaj, Hu, Junbo, Zhang, Xuemin, Li, Huiyan, Lin, Hui-Kuan

“…RLR-mediated type I IFN production plays a pivotal role in elevating host immunity for viral clearance and cancer immune surveillance. Here, we report that…”
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SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis by Wang, Guihua, Long, Jie, Gao, Yuan, Zhang, Weina, Han, Fei, Xu, Chuan, Sun, Li, Yang, Shun-Chin, Lan, Jingqin, Hou, Zhenlin, Cai, Zhen, Jin, Guoxiang, Hsu, Che-Chia, Wang, Yu-Hui, Hu, Junbo, Chen, Tsai-Yu, Li, Hongyu, Lee, Min Gyu, Lin, Hui-Kuan

“…The serine/threonine kinase Akt plays a central role in cell proliferation, survival and metabolism, and its hyperactivation is linked to cancer progression…”
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The critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistance by Han, Fei, Li, Chien-Feng, Cai, Zhen, Zhang, Xian, Jin, Guoxiang, Zhang, Wei-Na, Xu, Chuan, Wang, Chi-Yun, Morrow, John, Zhang, Shuxing, Xu, Dazhi, Wang, Guihua, Lin, Hui-Kuan

“…PI3K/Akt signaling is activated in cancers and governs tumor initiation and progression, but how Akt is activated under diverse stresses is poorly understood…”
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Pharmacological Inactivation of Skp2 SCF Ubiquitin Ligase Restricts Cancer Stem Cell Traits and Cancer Progression by Chan, Chia-Hsin, Morrow, John Kenneth, Li, Chien-Feng, Gao, Yuan, Jin, Guoxiang, Moten, Asad, Stagg, Loren J., Ladbury, John E., Cai, Zhen, Xu, Dazhi, Logothetis, Christopher J., Hung, Mien-Chie, Zhang, Shuxing, Lin, Hui-Kuan

“…Skp2 E3 ligase is overexpressed in numerous human cancers and plays a critical role in cell-cycle progression, senescence, metabolism, cancer progression, and…”
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Mitophagy promotes sorafenib resistance through hypoxia-inducible ATAD3A dependent Axis by Wu, Hong, Wang, Tao, Liu, Yiqiang, Li, Xin, Xu, Senlin, Wu, Changtao, Zou, Hongbo, Cao, Mianfu, Jin, Guoxiang, Lang, Jinyi, Wang, Bin, Liu, Baohua, Luo, Xiaolin, Xu, Chuan

“…The identification of novel targets for recovering sorafenib resistance is pivotal for Hepatocellular carcinoma (HCC) patients. Mitophagy is the programmed…”
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Post-Translational Modification of Lamins: Mechanisms and Functions by Zheng, Mingyue, Jin, Guoxiang, Zhou, Zhongjun

“…Lamins are the ancient type V intermediate filament proteins contributing to diverse biological functions, such as the maintenance of nuclear morphology,…”
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Isthmin-1 (Ism1) modulates renal branching morphogenesis and mesenchyme condensation during early kidney development by Gao, Ge, Li, Xiaoping, Jiang, Zhixin, Osorio, Liliana, Tang, Ying Lam, Yu, Xueqing, Jin, Guoxiang, Zhou, Zhongjun

“…The outgrowth of epithelial bud followed by reiterated bifurcations during renal development is driven by the ligand-receptor interactions between the…”
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MOF-mediated acetylation of UHRF1 enhances UHRF1 E3 ligase activity to facilitate DNA methylation maintenance by Wang, Linsheng, Yang, Xi, Zhao, Kaiqiang, Huang, Shengshuo, Qin, Yiming, Chen, Zixin, Hu, Xiaobin, Jin, Guoxiang, Zhou, Zhongjun

“…The multi-domain protein UHRF1 (ubiquitin-like, containing PHD and RING finger domains, 1) recruits DNMT1 for DNA methylation maintenance during DNA…”
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A hypoxia-responsive TRAF6–ATM–H2AX signalling axis promotes HIF1α activation, tumorigenesis and metastasis by Rezaeian, Abdol-Hossein, Li, Chien-Feng, Wu, Ching-Yuan, Zhang, Xian, Delacerda, Jorge, You, M. James, Han, Fei, Cai, Zhen, Jeong, Yun Seong, Jin, Guoxiang, Phan, Liem, Chou, Ping-Chieh, Lee, Mong-Hong, Hung, Mien-Chie, Sarbassov, Dos, Lin, Hui-Kuan

“…The understanding of how hypoxia stabilizes and activates HIF1α in the nucleus with related oncogenic signals could revolutionize targeted therapy for cancers…”
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MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis by Wong, Hoi Leong Xavier, Jin, Guoxiang, Cao, Renhai, Zhang, Shuo, Cao, Yihai, Zhou, Zhongjun

“…Lymphangiogensis is involved in various pathological conditions, such as arthritis and cancer metastasis. Although many factors have been identified to…”
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Skp2-Dependent Ubiquitination and Activation of LKB1 Is Essential for Cancer Cell Survival under Energy Stress by Lee, Szu-Wei, Li, Chien-Feng, Jin, Guoxiang, Cai, Zhen, Han, Fei, Chan, Chia-Hsin, Yang, Wei-Lei, Li, Bin-Kui, Rezaeian, Abdol Hossein, Li, Hong-Yu, Huang, Hsuan-Ying, Lin, Hui-Kuan

“…LKB1 is activated by forming a heterotrimeric complex with STRAD and MO25. Recent studies suggest that LKB1 has pro-oncogenic functions, besides acting as a…”
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MOF-mediated acetylation of SIRT6 disrupts SIRT6-FOXA2 interaction and represses SIRT6 tumor-suppressive function by upregulating ZEB2 in NSCLC by Zhao, Kaiqiang, Zheng, Mingyue, Su, Zezhuo, Ghosh, Shrestha, Zhang, Chao, Zhong, Wenzhao, Ho, Joshua Wing Kei, Jin, Guoxiang, Zhou, Zhongjun

“…Mammalian sirtuin 6 (SIRT6) regulates a spectrum of vital biological processes and has long been implicated in the progression of cancer. However, the…”
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SIRPγ-expressing cancer stem-like cells promote immune escape of lung cancer via Hippo signaling by Xu, Chuan, Jin, Guoxiang, Wu, Hong, Cui, Wei, Wang, Yu-Hui, Manne, Rajesh Kumar, Wang, Guihua, Zhang, Weina, Zhang, Xian, Han, Fei, Cai, Zhen, Pan, Bo-Syong, Hsu, Che-Chia, Liu, Yiqiang, Zhang, Anmei, Long, Jie, Zou, Hongbo, Wang, Shuang, Ma, Xiaodan, Duan, Jinling, Wang, Bin, Liu, Weihui, Lan, Haitao, Xiong, Qing, Xue, Gang, Chen, Zhongzhu, Xu, Zhigang, Furth, Mark E, Haigh Molina, Sarah, Lu, Yong, Xie, Dan, Bian, Xiu-Wu, Lin, Hui-Kuan

“…Cancer stem-like cells (CSLCs) acquire enhanced immune checkpoint responses to evade immune cell killing and promote tumor progression. Here we showed that…”
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PRMT1 reverts the immune escape of necroptotic colon cancer through RIP3 methylation by Zhang, Lian, He, Yujiao, Jiang, Yi, Wu, Qi, Liu, Yanchen, Xie, Qingqiang, Zou, Yuxiu, Wu, Jiaqian, Zhang, Chundong, Zhou, Zhongjun, Bian, Xiu-Wu, Jin, Guoxiang

“…Necroptosis plays a double-edged sword role in necroptotic cancer cell death and tumor immune escape. How cancer orchestrates necroptosis with immune escape…”
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Skp2–MacroH2A1–CDK8 axis orchestrates G2/M transition and tumorigenesis by Xu, Dazhi, Li, Chien-Feng, Zhang, Xian, Gong, Zhaohui, Chan, Chia-Hsin, Lee, Szu-Wei, Jin, Guoxiang, Rezaeian, Abdol-Hossein, Han, Fei, Wang, Jing, Yang, Wei-Lei, Feng, Zi-Zhen, Chen, Wei, Wu, Ching-Yuan, Wang, Ying-Jan, Chow, Lu-Ping, Zhu, Xiao-Feng, Zeng, Yi-Xin, Lin, Hui-Kuan

“…Understanding the mechanism by which cell growth, migration, polyploidy, and tumorigenesis are regulated may provide important therapeutic strategies for…”
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Single-cell transcriptome atlas in C57BL/6 mice encodes morphological phenotypes in the aging kidneys by Yang, Shanzhi, Liu, Peimin, Zhang, Yan, Xu, Haosen, Lan, Jinyi, Jiang, Huan, Jin, Guoxiang, Bai, Xiaoyan

“…C57BL/6 mice are frequently utilized as murine models with the desired genetic background for altertion in multiple research contexts. So far, there is still a…”
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Skp2-Mediated RagA Ubiquitination Elicits a Negative Feedback to Prevent Amino-Acid-Dependent mTORC1 Hyperactivation by Recruiting GATOR1 by Jin, Guoxiang, Lee, Szu-Wei, Zhang, Xian, Cai, Zhen, Gao, Yuan, Chou, Ping-Chieh, Rezaeian, Abdol Hossein, Han, Fei, Wang, Chi-Yun, Yao, Juo-Chin, Gong, Zhaohui, Chan, Chia-Hsin, Huang, Chih-Yang, Tsai, Fuu-Jen, Tsai, Chang-Hai, Tu, Shih-Hsin, Wu, Chih-Hsiung, Sarbassov, Dos D., Ho, Yuan-Soon, Lin, Hui-Kuan

“…The regulation of RagAGTP is important for amino-acid-induced mTORC1 activation. Although GATOR1 complex has been identified as a negative regulator for mTORC1…”
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MPC1 deficiency accelerates lung adenocarcinoma progression through the STAT3 pathway by Zou, Hongbo, Chen, Qian, Zhang, Anmei, Wang, Songtao, Wu, Hong, Yuan, Ye, Wang, Shuang, Yu, Jing, Luo, Mao, Wen, Xianmei, Cui, Wei, Fu, Wenjuan, Yu, Ruilian, Chen, Lin, Zhang, Ming, Lan, Haitao, Zhang, Xia, Xie, Qichao, Jin, Guoxiang, Xu, Chuan

“…Mitochondrial pyruvate carrier 1 (MPC1), a key factor that controls pyruvate transportation in the mitochondria, is known to be frequently dysregulated in…”
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H3 ubiquitination by NEDD4 regulates H3 acetylation and tumorigenesis by Zhang, Xian, Li, Binkui, Rezaeian, Abdol Hossein, Xu, Xiaohong, Chou, Ping-Chieh, Jin, Guoxiang, Han, Fei, Pan, Bo-Syong, Wang, Chi-Yun, Long, Jie, Zhang, Anmei, Huang, Chih-Yang, Tsai, Fuu-Jen, Tsai, Chang-Hai, Logothetis, Christopher, Lin, Hui-Kuan

“…Dynamic changes in histone modifications under various physiological cues play important roles in gene transcription and cancer. Identification of new histone…”
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Author Correction: SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis by Wang, Guihua, Long, Jie, Gao, Yuan, Zhang, Weina, Han, Fei, Xu, Chuan, Sun, Li, Yang, Shun-Chin, Lan, Jingqin, Hou, Zhenlin, Cai, Zhen, Jin, Guoxiang, Hsu, Che-Chia, Wang, Yu-Hui, Hu, Junbo, Chen, Tsai-Yu, Li, Hongyu, Lee, Min Gyu, Lin, Hui-Kuan

“…A Correction to this paper has been published: https://doi.org/10.1038/s41556-021-00686-x…”
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