Search Results - "Jin Gu Lee"

Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor by Lee, Jin-Gu, Huang, Weiliang, Lee, Hangnoh, van de Leemput, Joyce, Kane, Maureen A, Han, Zhe

“…SARS-CoV-2 causes COVID-19 which has a widely diverse disease profile. The mechanisms underlying its pathogenicity remain unclear. We set out to identify the…”
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Energy-Efficient Cluster-Head Selection for Wireless Sensor Networks Using Sampling-Based Spider Monkey Optimization by Lee, Jin-Gu, Chim, Seyha, Park, Ho-Hyun

“…Extending the lifetime and stability of wireless sensor networks (WSNs) through efficient energy consumption remains challenging. Though clustering has…”
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Unconventional secretion of misfolded proteins promotes adaptation to proteasome dysfunction in mammalian cells by Lee, Jin-Gu, Takahama, Shokichi, Zhang, Guofeng, Tomarev, Stanislav I., Ye, Yihong

“…To safeguard proteomic integrity, cells rely on the proteasome to degrade aberrant polypeptides, but it is unclear how cells remove defective proteins that…”
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Bag6/Bat3/Scythe: A novel chaperone activity with diverse regulatory functions in protein biogenesis and degradation by Lee, Jin-Gu, Ye, Yihong

“…Upon emerging from the ribosome exiting tunnel, polypeptide folding occurs immediately with the assistance of both ribosome‐associated and free chaperones…”
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The ERAD inhibitor Eeyarestatin I is a bifunctional compound with a membrane-binding domain and a p97/VCP inhibitory group by Wang, Qiuyan, Shinkre, Bidhan A, Lee, Jin-gu, Weniger, Marc A, Liu, Yanfen, Chen, Weiping, Wiestner, Adrian, Trenkle, William C, Ye, Yihong

“…Protein homeostasis in the endoplasmic reticulum (ER) has recently emerged as a therapeutic target for cancer treatment. Disruption of ER homeostasis results…”
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Commentary: Referral for Lung Transplantation Should Be Carefully Decided for Patients with COVID-19 Acute Respiratory Distress Syndrome by Jin Gu Lee

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Dilated Skip Convolution for Facial Landmark Detection by Chim, Seyha, Lee, Jin-Gu, Park, Ho-Hyun

“…Facial landmark detection has gained enormous interest for face-related applications due to its success in facial analysis tasks such as facial recognition,…”
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Functional analysis of SARS-CoV-2 proteins in Drosophila identifies Orf6-induced pathogenic effects with Selinexor as an effective treatment by Zhu, Jun-Yi, Lee, Jin-Gu, van de Leemput, Joyce, Lee, Hangnoh, Han, Zhe

“…SARS-CoV-2 causes COVID-19 with a widely diverse disease profile that affects many different tissues. The mechanisms underlying its pathogenicity in host…”
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DNAJC5 facilitates USP19-dependent unconventional secretion of misfolded cytosolic proteins by Xu, Yue, Cui, Lei, Dibello, Anthony, Wang, Lihui, Lee, Juhyung, Saidi, Layla, Lee, Jin-Gu, Ye, Yihong

“…Cell-to-cell transmission of misfolded proteins propagates proteotoxic stress in multicellular organisms when transmitted polypeptides serve as a seeding…”
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A Ubiquitin-like Domain Recruits an Oligomeric Chaperone to a Retrotranslocation Complex in Endoplasmic Reticulum-associated Degradation by Xu, Yue, Liu, Yanfen, Lee, Jin-gu, Ye, Yihong

“…The Bag6-Ubl4A-Trc35 complex is a multifunctional chaperone that regulates various cellular processes. The diverse functions of Bag6 are supported by its…”
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Characterization of the Deubiquitinating Activity of USP19 and Its Role in Endoplasmic Reticulum-associated Degradation by Lee, Jin-Gu, Kim, Woong, Gygi, Steven, Ye, Yihong

“…Deubiquitinating enzymes (DUBs) regulate various cellular processes ranging from protein degradation to cellular signaling. USP19, the only DUB containing a…”
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SSD-TSEFFM: New SSD Using Trident Feature and Squeeze and Extraction Feature Fusion by Hwang, Young-Joon, Lee, Jin-Gu, Moon, Un-Chul, Park, Ho-Hyun

“…The single shot multi-box detector (SSD) exhibits low accuracy in small-object detection; this is because it does not consider the scale contextual information…”
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A SNARE protective pool antagonizes APOL1 renal toxicity in Drosophila nephrocytes by Lee, Jin-Gu, Fu, Yulong, Zhu, Jun-Yi, Wen, Pei, van de Leemput, Joyce, Ray, Patricio E, Han, Zhe

“…People of Sub-Saharan African ancestry are at higher risk of developing chronic kidney disease (CKD), attributed to the Apolipoprotein L1 (APOL1) gene risk…”
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Risk factors and mortality of acute kidney injury within 1 month after lung transplantation by Kim, Nam Eun, Kim, Chi Young, Kim, Song Yee, Kim, Ha Eun, Lee, Jin Gu, Paik, Hyo Chae, Park, Moo Suk

“…After lung transplantation (LT), some patients are at risk of acute kidney injury (AKI), which is associated with worse outcomes and increased mortality…”
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Analysis of Unexpected Conversion to Thoracotomy During Thoracoscopic Lobectomy in Lung Cancer by Byun, Chun Sung, MD, Lee, Sungsoo, MD, PhD, Kim, Dae Joon, MD, Lee, Jin Gu, MD, Lee, Chang Young, MD, Jung, Inkyung, PhD, Chung, Kyung Young, MD

“…Background Since anatomical lung resection by video-assisted thoracoscopic surgery (VATS) was first introduced, VATS has played a major role in lung cancer…”
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RGS2 Suppresses Breast Cancer Cell Growth via a MCPIP1-Dependent Pathway by Lyu, Ji Hyo, Park, Dae-Weon, Huang, Bin, Kang, Su Hwan, Lee, Soo Jung, Lee, Chuhee, Bae, Yoe-Sik, Lee, Jin-Gu, Baek, Suk-Hwan

“…ABSTRACT Regulator of G protein signaling 2 (RGS2) is a member of a family of proteins that functions as a GTPase‐activating protein (GAP) for Gα subunits…”
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APOL1-G2 accelerates nephrocyte cell death by inhibiting the autophagy pathway by Zhu, Jun-Yi, Lee, Jin-Gu, Fu, Yulong, van de Leemput, Joyce, Ray, Patricio E, Han, Zhe

“…People of African ancestry who carry the APOL1 risk alleles G1 or G2 are at high risk of developing kidney diseases through not fully understood mechanisms…”
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USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation by Liu, Yanfen, Soetandyo, Nia, Lee, Jin-Gu, Liu, Liping, Xu, Yue, Clemons, Jr, William M, Ye, Yihong

“…Physiological adaptation to proteotoxic stress in the endoplasmic reticulum (ER) requires retrotranslocation of misfolded proteins into the cytoplasm for…”
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Thoracoscopic esophagectomy for esophageal cancer: Feasibility and safety of robotic assistance in the prone position by Kim, Dae Joon, MD, Hyung, Woo Jin, MD, PhD, Lee, Chang Young, MD, Lee, Jin-Gu, MD, Haam, Seok Jin, MD, Park, In-Kyu, MD, Chung, Kyung Young, MD

“…Objective To assess the feasibility and safety of robot-assisted thoracoscopic esophagectomy for esophageal cancer in the prone position. Methods Twenty-one…”
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Long-term clinical course and progression of lymphangioleiomyomatosis in a single lung transplant referral centre in Korea by Chang, Shihwan, Choi, Ji Soo, Leem, Ah Young, Lee, Su Hwan, Lee, Sang Hoon, Kim, Song Yee, Chung, Kyung Soo, Jung, Ji Ye, Kang, Young Ae, Kim, Young Sam, Lee, Jin Gu, Paik, Hyo Chae, Shim, Hyo Sup, Lee, Eun Hye, Park, Moo Suk

“…We aimed to describe the clinical features of lymphangioleiomyomatosis (LAM) in Korean patients and identify factors associated with progressive disease (PD)…”
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