Search Results - "Jin, Zhongmou"

Accumulation of microbial DNAs promotes to islet inflammation and β cell abnormalities in obesity in mice by Gao, Hong, Luo, Zhenlong, Ji, Yudong, Tang, Kechun, Jin, Zhongmou, Ly, Crystal, Sears, Dorothy D., Mahata, Sushil, Ying, Wei

“…Various microbial products leaked from gut lumen exacerbate tissue inflammation and metabolic disorders in obesity. Vsig4+ macrophages are key players…”
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Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis by Gao, Hong, Jin, Zhongmou, Bandyopadhyay, Gautam, Wang, Gaowei, Zhang, Dinghong, Rocha, Karina Cunha e, Liu, Xiao, Zhao, Huayi, Kisseleva, Tatiana, Brenner, David A., Karin, Michael, Ying, Wei

“…Hepatocytes have important roles in liver iron homeostasis, abnormalities in which are tightly associated with liver steatosis and fibrosis. Here, we show that…”
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Adipose Tissue Macrophages Modulate Obesity-Associated β Cell Adaptations through Secreted miRNA-Containing Extracellular Vesicles by Gao, Hong, Luo, Zhenlong, Jin, Zhongmou, Ji, Yudong, Ying, Wei

“…Obesity induces an adaptive expansion of β cell mass and insulin secretion abnormality. Expansion of adipose tissue macrophages (ATMs) is a hallmark of…”
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Microbial DNA Enrichment Promotes Adrenomedullary Inflammation, Catecholamine Secretion, and Hypertension in Obese Mice by Gao, Hong, Jin, Zhongmou, Tang, Kechun, Ji, Yudong, Suarez, Jorge, Suarez, Jorge A, Cunha E Rocha, Karina, Zhang, Dinghong, Dillmann, Wolfgang H, Mahata, Sushil K, Ying, Wei

“…Background Obesity is an established risk factor for hypertension. Although obesity-induced gut barrier breach leads to the leakage of various…”
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Gut lumen-leaked microbial DNA causes myocardial inflammation and impairs cardiac contractility in ageing mouse heart by Gao, Hong, Wang, Ke, Suarez, Jorge A, Jin, Zhongmou, Rocha, Karina Cunha E, Zhang, Dinghong, Farrell, Andrea, Truong, Tyler, Tekin, Yasemin, Tan, Breanna, Jung, Hyun Suh, Kempf, Julia, Mahata, Sushil K, Dillmann, Wolfgang H, Suarez, Jorge, Ying, Wei

“…Emerging evidence indicates the critical roles of microbiota in mediating host cardiac functions in ageing, however, the mechanisms underlying the…”
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Gut microbial DNA and immune checkpoint gene Vsig4/CRIg are key antagonistic players in healthy aging and age-associated development of hypertension and diabetes by Liu, Matthew A, Shahabi, Shandy, Jati, Suborno, Tang, Kechun, Gao, Hong, Jin, Zhongmou, Miller, Wyatt, Meunier, Frédéric A, Ying, Wei, van den Bogaart, Geert, Ghosh, Gourisankar, Mahata, Sushil K

“…Aging is associated with the development of insulin resistance and hypertension which may stem from inflammation induced by accumulation of toxic bacterial DNA…”
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MiR-690, an exosomal-derived miRNA from M2-polarized macrophages, improves insulin sensitivity in obese mice by Ying, Wei, Gao, Hong, Dos Reis, Felipe Castellani Gomes, Bandyopadhyay, Gautam, Ofrecio, Jachelle M., Luo, Zhenlong, Ji, Yudong, Jin, Zhongmou, Ly, Crystal, Olefsky, Jerrold M.

“…Insulin resistance is a major pathophysiologic defect in type 2 diabetes and obesity, while anti-inflammatory M2-like macrophages are important in maintaining…”
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Microbial DNA enrichment promotes liver steatosis and fibrosis in the course of non‐alcoholic steatohepatitis by Luo, Zhenlong, Ji, Yudong, Zhang, Dinghong, Gao, Hong, Jin, Zhongmou, Yang, Meixiang, Ying, Wei

“…Aim Low‐grade inflammation is the hallmark of non‐alcoholic fatty liver diseases (NAFLD) and non‐alcoholic steatohepatitis (NASH). The leakage of…”
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CRIg+ Macrophages Prevent Gut Microbial DNA–Containing Extracellular Vesicle–Induced Tissue Inflammation and Insulin Resistance by Luo, Zhenlong, Ji, Yudong, Gao, Hong, Gomes Dos Reis, Felipe Castellani, Bandyopadhyay, Gautam, Jin, Zhongmou, Ly, Crystal, Chang, Ya-ju, Zhang, Dinghong, Kumar, Deepak, Ying, Wei

“…Liver CRIg+ (complement receptor of the immunoglobulin superfamily) macrophages play a critical role in filtering bacteria and their products from circulation…”
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MiR-690 treatment causes decreased fibrosis and steatosis and restores specific Kupffer cell functions in NASH by Gao, Hong, Jin, Zhongmou, Bandyopadhyay, Gautam, Cunha E Rocha, Karina, Liu, Xiao, Zhao, Huayi, Zhang, Dinghong, Jouihan, Hani, Pourshahian, Soheil, Kisseleva, Tatiana, Brenner, David A, Ying, Wei, Olefsky, Jerrold M

“…Nonalcoholic steatohepatitis (NASH) is a liver disease associated with significant morbidity. Kupffer cells (KCs) produce endogenous miR-690 and, via exosome…”
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Microbial DNA Enrichment Promotes Adrenomedullary Inflammation, Catecholamine Secretion, and Hypertension in Obese Mice by Jin, Zhongmou

“…Obesity is an established risk factor for hypertension. Building upon the known fact that obesity-induced gut barrier breach leads to the leakage of various…”
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Restoring SRSF3 in Kupffer cells attenuates obesity-related insulin resistance by Gao, Hong, Rocha, Karina Cunha E, Jin, Zhongmou, Kumar, Deepak, Zhang, Dinghong, Wang, Ke, Das, Manasi, Farrell, Andrea, Truong, Tyler, Tekin, Yasemin, Jung, Hyun Suh, Kempf, Julia, Webster, Nicholas J G, Ying, Wei

“…In obesity, depletion of Kupffer cells (KCs) expressing CRIg (complement receptor of the immunoglobulin superfamily) leads to microbial DNA accumulation, which…”
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Hepatocyte-derived exosomes from early onset obese mice promote insulin sensitivity through miR-3075 by Ji, Yudong, Luo, Zhenlong, Gao, Hong, Dos Reis, Felipe Castellani Gomes, Bandyopadhyay, Gautam, Jin, Zhongmou, Manda, Kameswari Ananthakrishnan, Isaac, Roi, Yang, Meixiang, Fu, Wenxian, Ying, Wei, Olefsky, Jerrold M.

“…In chronic obesity, hepatocytes become insulin resistant and exert important effects on systemic metabolism. Here we show that in early onset obesity (4 weeks…”
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