Search Results - "Jin, Yafei"

Efficacy and safety of olmesartan medoxomil‐amlodipine besylate tablet in Chinese patients with essential hypertension: A prospective, single‐arm, multi‐center, real‐world study by Cui, Zhaoqiang, Qiu, Zhaohui, Cheng, Wenli, Hu, Wei, Ma, Genshan, Cai, Xiaojun, Jin, Yafei, Zhao, Yi, He, Liqun, Li, Ying, Bu, Peili, Chen, Xiaoping, Wang, Ruxing, Chen, Lin, Dong, Peng, Feng, Liuliu, Han, Xuebin, Hong, Mei, Hou, Yinglong, Liao, Minlei, Wang, Mingliang, Wang, Xiaoyan, Xie, Jianhong, Xu, Yawei, Wang, Zhenxing, Huang, Kai, Li, Yongle, Li, Dongsheng, Ji, Xiaojun, Huang, Jing, Wang, Jun, Fang, Danhong, Wang, Jian'an, Tang, Lijiang, Liu, Yingwu, Fu, Guosheng, Du, Juan, Wang, Ling, Liu, Mengqi, Ge, Junbo

“…There lacks real‐world study with a large sample size assessing olmesartan medoxomil‐amlodipine besylate (OM‐AML) tablet. Therefore, this study aimed to…”
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Optimization of Eliglustat-Based Glucosylceramide Synthase Inhibitors as Substrate Reduction Therapy for Gaucher Disease Type 3 by Wilson, Michael W, Shu, Liming, Hinkovska-Galcheva, Vania, Jin, Yafei, Rajeswaran, Walajapet, Abe, Akira, Zhao, Ting, Luo, Ruijuan, Wang, Lu, Wen, Bo, Liou, Benjamin, Fannin, Venette, Sun, Duxin, Sun, Ying, Shayman, James A, Larsen, Scott D

“…There remain no approved therapies for rare but devastating neuronopathic glyocosphingolipid storage diseases, such as Sandhoff, Tay-Sachs, and Gaucher disease…”
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Enhanced external counterpulsation inhibits intimal hyperplasia by modifying shear stress-responsive gene expression in hypercholesterolemic pigs by YAN ZHANG, XIAOHONG HE, DIANQIU FANG, KUIJIAN WANG, LAWSON, William E, HUI, John C. K, ZHENSHENG ZHENG, GUIFU WU, XIAOLIN CHEN, HONG MA, DONGHONG LIU, JINYUN LUO, ZHIMIN DU, YAFEI JIN, YAN XIONG, JIANGUI HE

“…Enhanced external counterpulsation (EECP) is a circulation assist device that may improve endothelial dysfunction by increasing shear stress. Chronic exposure…”
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Enhanced External Counterpulsation Attenuates Atherosclerosis Progression Through Modulation of Proinflammatory Signal Pathway by Zhang, Yan, He, Xiaohong, Liu, Donghong, Wu, Guifu, Chen, Xiaolin, Ma, Hong, Du, Zhimin, Dong, Yugang, Jin, Yafei, He, Wen, Wang, Kuijian, Lawson, William E, Hui, John C.K, Zheng, Zhensheng

“…OBJECTIVE—Shear stress may be the most crucial local factor affecting atherogenesis. The present study investigated the effect of exposure to increased shear…”
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Synthesis and structure–activity relationships of novel substituted 8-amino, 8-thio, and 1,8-pyrazole congeners of antitubercular rifamycin S and rifampin by Jin, Yafei, Gill, Sumandeep K., Kirchhoff, Paul D., Wan, Baojie, Franzblau, Scott G., Garcia, George A., Showalter, H.D. Hollis

“…A series of rifamycin S and rifampin analogues incorporating substituted 8-amino, 8-thio, and 1,8-pyrazole substituents has been synthesized. The compounds…”
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Study on Oxygen-Enriched Combustion Characteristics of Blast Furnace Gas Boiler by Hu, Yuxuan, Wang, Du, Liao, Li, Jin, Yafei, Wang, Tingju

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Mechanism of Action and Structural Requirements of Constrained Peptide Inhibitors of RGS Proteins by Roof, Rebecca A., Jin, Yafei, Roman, David L., Sunahara, Roger K., Ishii, Masaru, Mosberg, Henry I., Neubig, Richard R.

“…Regulators of G‐protein signaling (RGS) accelerate guanine triphosphate hydrolysis by Gα‐subunits and profoundly inhibit signaling by G protein‐coupled…”
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Association between ambient particulate matter (PM10) and incidence of diabetes in northwest of China: A prospective cohort study by Wang, Minzhen, Jin, Yafei, Dai, Tian, Yu, Cheng, Zheng, Shan, Nie, Yonghong, Bai, Yana

“…We aimed to assess the association between long-term exposure to ambient PM10 and risk of diabetes incidence, based on the “Jinchang Cohort” platform in the…”
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A novel synthesis of substituted 3‐amino and 3‐thio pyrimido[5,4‐e]‐1,2,4‐triazine‐5,7(1H,6H)‐diones by Xu, Hao, Powelson, Ian A., Jin, Yafei, Showalter, Hollis D.

“…Fervenulin is a natural product that has been extensively studied due to its molecular features and breadth of biological activities. Published studies have…”
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Synthesis of CID-cleavable protein crosslinking agents containing quaternary amines for structural mass spectrometry by Hagen, Susan E, Liu, Kun, Jin, Yafei, Piersimoni, Lolita, Andrews, Philip C, Showalter, Hollis D

“…Two novel cyclic quaternary amine crosslinking probes are synthesized for structural mass spectrometry of protein complexes in solution and for analysis of…”
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Design and synthesis of triarylacrylonitrile analogues of tamoxifen with improved binding selectivity to protein kinase C by Carpenter, Colleen, Sorenson, Roderick J., Jin, Yafei, Klossowski, Szymon, Cierpicki, Tomasz, Gnegy, Margaret, Showalter, Hollis D.

“…[Display omitted] The clinical selective estrogen receptor modulator tamoxifen is also a modest inhibitor of protein kinase C, a target implicated in several…”
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Design, synthesis, and biological activity of 5′-phenyl-1,2,5,6-tetrahydro-3,3′-bipyridine analogues as potential antagonists of nicotinic acetylcholine receptors by Jin, Yafei, Huang, Xiaoqin, Papke, Roger L., Jutkiewicz, Emily M., Showalter, Hollis D., Zhan, Chang-Guo

“…Structure-based molecular design starting from a known non-specific agonist (1) of nicotinic acetylcholine receptors has generated a novel antagonist (3a) that…”
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Efficacy and safety of olmesartan medoxomil‑amlodipine besylate tablets (Sevikar ® ) in older patients with essential hypertension: Subgroup analysis from the Sevikar study by Cui, Zhaoqiang, Qiu, Zhaohui, Cheng, Wenli, Hu, Wei, Ma, Genshan, Cai, Xiaojun, Jin, Yafei, Zhao, Yi, He, Liqun, Li, Ying, Bu, Peili, Chen, Xiaoping, Wang, Ruxing, Chen, Lin, Dong, Peng, Feng, Liuliu, Han, Xuebin, Hong, Mei, Hou, Yinglong, Liao, Minlei, Wang, Mingliang, Wang, Xiaoyan, Xie, Jianhong, Xu, Yawei, Wang, Zhenxing, Huang, Kai, Li, Yongle, Li, Dongsheng, Ji, Xiaojun, Huang, Jing, Wang, Jun, Fang, Danhong, Wang, Jian'An, Tang, Lijiang, Liu, Yingwu, Fu, Guosheng, Du, Juan, Wang, Ling, Liu, Mengqi, Ge, Junbo

“…Essential hypertension is a notable threat for the older (age, [greater than or equal to] 65 years) population. However, to the best of our knowledge, a…”
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GW27-e0567 Elevation in blood flow and shear stress attenuates endothelial barrier disruption induced by Oxidized Low-Density Lipoprotein by Yan, Zhang, He, Xiaohong, Li, Yanling, Zhong, Tingting, Liu, Donghong, Chen, Xiaolin, Jin, Yafei, Ma, Hong, Du, Zhimin, Dong, Yugang, Lawson, William E, Hui, John C.K, Zheng, Zhensheng, Zhang, Yan

“…Methods Human umbilical vein endothelial cells (HUVECs) monolayers were exposed to 0, 5, 25 dyne/cm2 laminar shear stress (LSS) with 10ug/ml oxidized low-…”
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GW27-e0567 Elevation in blood flow and shear stress attenuates endothelial barrier disruption induced by Oxidized Low-Density Lipoprotein: Translational Medical Research of Cardiovascular Disease by Yan, Zhang, He, Xiaohong, Li, Yanling, Zhong, Tingting, Liu, Donghong, Chen, Xiaolin, Jin, Yafei, Ma, Hong, Du, Zhimin, Dong, Yugang, Lawson, William E, Hui, John CK, Zheng, Zhensheng, Zhang, Yan

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Synthesis and structure–activity relationships of 2-amino-3-carboxy-4-phenylthiophenes as novel atypical protein kinase C inhibitors by Titchenell, Paul M., Hollis Showalter, H.D., Pons, Jean-François, Barber, Alistair J., Jin, Yafei, Antonetti, David A.

“…Recent evidence suggests atypical protein kinase C (aPKC) isoforms are required for both TNF- and VEGF-induced breakdown of the blood–retinal barrier (BRB) and…”
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ENHANCED EXTERNAL COUNTERPULSATION REDUCES VASCULAR INFLAMMATION PROMOTED BY HYPERCHOLESTEROLEMIA by Lawson, William E, Zhang, Yan, He, Xiaohong, Liu, Donghong, Wu, Guifu, Chen, Xiaolin, Ma, Hong, Du, Zhimin, Dong, Yugang, Jin, Yafei, He, Wen, Wang, Kuijian, Hui, John CK, Zheng, Zhensheng

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Abstract 3759: Enhanced External Counterpulsation Arrests the Progression of Atherosclerosis by Regulating Cellular Apoptosis and Proliferation Signaling Pathway by Zhang, Yan, Ma, Hong, He, Xiaohong, Wu, Guifu, Chen, Xiaolin, Liu, Donghong, Du, Zhimin, Dong, Yugan, Jin, Yafei, He, Wen, Wang, Kuijian, Luo, Jinyun, Xiong, Yan, Lawson, William E, Hui, John C, Zheng, Zhensheng

“…Abstract only Shear stress may be the most crucial local factor affecting atherogenesis. Enhanced External Counterpulsation (EECP) has been documented to…”
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Research Article: Mechanism of Action and Structural Requirements of Constrained Peptide Inhibitors of RGS Proteins by Roof, Rebecca A, Jin, Yafei, Roman, David L, Sunahara, Roger K, Ishii, Masaru, Mosberg, Henry I, Neubig, Richard R

“…Regulators of G-protein signaling (RGS) accelerate guanine triphosphate hydrolysis by G alpha -subunits and profoundly inhibit signaling by G protein-coupled…”
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Structure-based design, synthesis, and activity of peptide inhibitors of RGS4 GAP activity by Jin, Yafei, Zhong, Huailing, Omnaas, John R, Neubig, Richard R, Mosberg, Henry I

“…One of the principal roles of the multifunctional regulator of G-protein signaling (RGS) proteins is to terminate G-protein-coupled receptor (GPCR) signaling…”
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