Search Results - "Jin, Ya‐Ge"

Activating transcription factor 3 in cardiovascular diseases: a potential therapeutic target by Zhou, Heng, Li, Ning, Yuan, Yuan, Jin, Ya-Ge, Guo, Haipeng, Deng, Wei, Tang, Qi-Zhu

“…Cardiovascular diseases (CVDs) are the primary causes of death worldwide. Among the numerous signaling molecules involved in CVDs, transcriptional factors…”
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TMEM173 protects against pressure overload‐induced cardiac hypertrophy by modulating autophagy by Jin, Ya‐Ge, Zhou, Heng, Fan, Di, Che, Yan, Wang, Zhao‐Peng, Wang, Sha‐Sha, Tang, Qi‐Zhu

“…TMEM173 has been reported to participate in endoplasmic reticulum stress, inflammation and immunology, all of which closely involved with cardiac hypertrophy…”
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Nobiletin attenuates cardiac dysfunction, oxidative stress, and inflammatory in streptozotocin: induced diabetic cardiomyopathy by Zhang, Ning, Yang, Zheng, Xiang, Shi-Zhao, Jin, Ya-Ge, Wei, Wen-Ying, Bian, Zhou-Yan, Deng, Wei, Tang, Qi-Zhu

“…Diabetic cardiomyopathy, characterized by the presence of diastolic and/or systolic myocardial dysfunction, is one of the major causes of heart failure…”
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T-bet deficiency attenuates cardiac remodelling in rats by Ma, Zhen-Guo, Dai, Jia, Yuan, Yu-Pei, Bian, Zhou-Yan, Xu, Si-Chi, Jin, Ya-Ge, Zhang, Xin, Tang, Qi-Zhu

“…Previous studies have suggested the involvement of CD4 + T lymphocytes in cardiac remodelling. T-bet can direct Th1 lineage commitment. This study aimed to…”
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Role of autophagy in a model of obesity: A long‑term high fat diet induces cardiac dysfunction by Che, Yan, Wang, Zhao-Peng, Yuan, Yuan, Zhang, Ning, Jin, Ya-Ge, Wan, Chun-Xia, Tang, Qi-Zhu

“…Obesity may induce end‑organ damage through metabolic syndrome, and autophagy serves a vital role in the pathogenesis of metabolic syndrome. The purpose of the…”
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Leukocyte immunoglobulin-like receptor B4 protects against cardiac hypertrophy via SHP-2-dependent inhibition of the NF-κB pathway by Zhou, Heng, Li, Ning, Yuan, Yuan, Jin, Ya-Ge, Wu, Qingqing, Yan, Ling, Bian, Zhou-Yan, Deng, Wei, Shen, Di-Fei, Li, Hongliang, Tang, Qi-Zhu

“…Cardiac hypertrophy is a complex pathological process, and the molecular mechanisms underlying hypertrophic remodeling have not been clearly elucidated…”
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Sesamin Protects Against Cardiac Remodeling Via Sirt3/ROS Pathway by Fan, Di, Yang, Zheng, Liu, Fang-yuan, Jin, Ya-Ge, Zhang, Ning, Ni, Jian, Yuan, Yuan, Liao, Hai-Han, Wu, Qing-Qing, Xu, Man, Deng, Wei, Tang, Qi-Zhu

“…Background/Aims: Cardiac remodeling is associated with oxidative stress. Sesamin, a well-known antioxidant from sesamin seeds, have been used extensively as…”
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Nobiletin, a Polymethoxy Flavonoid, Protects Against Cardiac Hypertrophy Induced by Pressure-Overload via Inhibition of NAPDH Oxidases and Endoplasmic Reticulum Stress by Zhang, Ning, Wei, Wen-Ying, Yang, Zheng, Che, Yan, Jin, Ya-Ge, Liao, Hai-Han, Wang, Sha-sha, Deng, Wei, Tang, Qi-Zhu

“…Abstract Background/Aims: An increase in oxidative stress has been implicated in the pathophysiology of pressure-overload induced cardiac hypertrophy…”
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Corosolic acid ameliorates cardiac hypertrophy via regulating autophagy by Wang, Zhao-Peng, Shen, Difei, Che, Yan, Jin, Ya-Ge, Wang, Sha-Sha, Wu, Qing-Qing, Zhou, Heng, Meng, Yan-Yan, Yuan, Yuan

“…Abstract Aim: In this work, we explored the role of corosolic acid (CRA) during pressure overload-induced cardiac hypertrophy. Methods and results: Cardiac…”
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Protective role of berberine in isoprenaline-induced cardiac fibrosis in rats by Che, Yan, Shen, Di-Fei, Wang, Zhao-Peng, Jin, Ya-Ge, Wu, Qing-Qing, Wang, Sha-Sha, Yuan, Yuan

“…Cardiac fibrosis is a crucial aspect of cardiac remodeling that can severely affect cardiac function. Cardiac fibroblasts surely influence this process…”
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Tetrandrine Attenuated Doxorubicin-Induced Acute Cardiac Injury in Mice by Wang, Cheng-Yu, Jie, Qiqiang, Jin, Ya-Ge, Li, Gang, Wu, Lin

“…Oxidative damage is closely involved in the development of doxorubicin- (DOX-) induced cardiotoxicity. It has been reported that tetrandrine can prevent the…”
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Puerarin Protects against Cardiac Fibrosis Associated with the Inhibition of TGF-β1/Smad2-Mediated Endothelial-to-Mesenchymal Transition by Tang, Qi-Zhu, Wang, Sha-Sha, Wang, Zhao-Peng, Che, Yan, Fan, Di, Zhang, Ning, Wu, Qing-Qing, Yuan, Yuan, Jin, Ya-Ge, Xiao, Yang

“…Background. Puerarin is a kind of flavonoids and is extracted from Chinese herb Kudzu root. Puerarin is widely used as an adjuvant therapy in Chinese clinics…”
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Sesamin prevents apoptosis and inflammation after experimental myocardial infarction by JNK and NF-κB pathways by Fan, Di, Yang, Zheng, Yuan, Yuan, Wu, Qing-Qing, Xu, Man, Jin, Ya-Ge, Tang, Qi-Zhu

“…Myocardial infarction is a devastating event, especially when reperfusion is not performed. The inflammatory response has been associated with the pathogenesis…”
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RNF13 protects against pathological cardiac hypertrophy through p62-NRF2 pathway by Guo, Sen, Zhang, Bin-Bin, Gao, Lu, Yu, Xiao-Yue, Shen, Ji-Hong, Yang, Fan, Zhang, Wen-Cai, Jin, Ya-Ge, Li, Gang, Wang, Yan-Ge, Han, Zhan-Ying, Liu, Yuan

“…Heart failure (HF) severely impairs human health because of its high incidence and mortality. Cardiac hypertrophy is the main cause of HF, while its underlying…”
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Mnk1 (Mitogen-Activated Protein Kinase–Interacting Kinase 1) Deficiency Aggravates Cardiac Remodeling in Mice by Yuan, Yuan, Yan, Ling, Wu, Qing-Qing, Zhou, Heng, Jin, Ya-Ge, Bian, Zhou-Yan, Deng, Wei, Yang, Zheng, Shen, Di-Fei, Zeng, Xiao-Feng, Wang, Sha-Sha, Li, Hongliang, Tang, Qi-Zhu

“…Identifying the key factor involved in cardiac remodeling is critically important for developing novel strategies to protect against heart failure. Here, the…”
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Corosolic acid attenuates cardiac fibrosis following myocardial infarction in mice by Wang, Zhao-Peng, Che, Yan, Zhou, Heng, Meng, Yan-Yan, Wu, Hai-Ming, Jin, Ya-Ge, Wu, Qing-Qing, Wang, Sha-Sha, Yuan, Yuan

“…Corosolic acid (CRA) is a pentacyclic triterpenoid isolated from Lagerstroemia speciosa. The aim of the present study was to determine whether CRA reduces…”
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Puerarin Protects against Cardiac Fibrosis Associated with the Inhibition of TGF-[beta]1/Smad2-Mediated Endothelial-to-Mesenchymal Transition by Jin, Ya-Ge, Yuan, Yuan, Wu, Qing-Qing, Zhang, Ning, Fan, Di, Che, Yan, Wang, Zhao- Peng, Xiao, Yang, Wang, Sha-Sha, Tang, Qi-Zhu

“…Background. Puerarin is a kind of flavonoids and is extracted from Chinese herb Kudzu root. Puerarin is widely used as an adjuvant therapy in Chinese clinics…”
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Aucubin Protects against TGFβ1-Induced Cardiac Fibroblasts Activation by Mediating the AMPKα/mTOR Signaling Pathway by Xiao, Yang, Chang, Wei, Wu, Qing-Qing, Jiang, Xiao-Han, Duan, Ming-Xia, Jin, Ya-Ge, Tang, Qi-Zhu

“…Fibrosis is a key feature of various cardiovascular diseases and compromises cardiac systolic and diastolic performance. The lack of effective anti-fibrosis…”
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Puerarin Protects against Cardiac Fibrosis Associated with the Inhibition of TGF- β 1/Smad2-Mediated Endothelial-to-Mesenchymal Transition by Jin, Ya-Ge, Yuan, Yuan, Wu, Qing-Qing, Zhang, Ning, Fan, Di, Che, Yan, Wang, Zhao-Peng, Xiao, Yang, Wang, Sha-Sha, Tang, Qi-Zhu

“…Puerarin is a kind of flavonoids and is extracted from Chinese herb Kudzu root. Puerarin is widely used as an adjuvant therapy in Chinese clinics. But little…”
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GW27-e0398 Mitogen-activated protein kinase interacting kinase 1 (Mnk1) Deficiency Aggravates Cardiac Remodeling via Regulation of Sprouty2-dependent ERK1/2 pathway by Yuan, Yuan, Yan, Ling, Wu, Qing-Qing, Zhou, Heng, Jin, Ya-Ge, Bian, Zhou-Yan, Deng, Wei, Yang, Zheng, Shen, Di-Fei, Zeng, Xiao-Feng, Wang, Sha-Sha, Li, Hongliang, Tang, Qi-Zhu

“…In line with the in vivo studies, Mnk1 knockdown by Mnk1 siRNA transfection resulted in exaggerated cardiomyocyte hypertrophy in Ang II-treated NRVMs…”
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