Search Results - "Jin, Xianming"

Structure-Based Drug Design of Novel Potent and Selective Tetrahydropyrazolo[1,5‑a]pyrazines as ATR Inhibitors by Barsanti, Paul A, Aversa, Robert J, Jin, Xianming, Pan, Yue, Lu, Yipin, Elling, Robert, Jain, Rama, Knapp, Mark, Lan, Jiong, Lin, Xiaodong, Rudewicz, Patrick, Sim, Janet, Taricani, Lorena, Thomas, George, Xiao, Linda, Yue, Qin

“…A saturation strategy focused on improving the selectivity and physicochemical properties of ATR inhibitor HTS hit 1 led to a novel series of highly potent and…”
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Structure-Based Drug Design of Novel, Potent, and Selective Azabenzimidazoles (ABI) as ATR Inhibitors by Barsanti, Paul A, Pan, Yue, Lu, Yipin, Jain, Rama, Cox, Matthew, Aversa, Robert J, Dillon, Michael P, Elling, Robert, Hu, Cheng, Jin, Xianming, Knapp, Mark, Lan, Jiong, Ramurthy, Savithri, Rudewicz, Patrick, Setti, Lina, Subramanian, Sharadha, Mathur, Michelle, Taricani, Lorena, Thomas, George, Xiao, Linda, Yue, Qin

“…Compound 13 was discovered through morphing of the ATR biochemical HTS hit 1. The ABI series was potent and selective for ATR. Incorporation of a 6-azaindole…”
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