Search Results - "Jin, Xiangshu"

Origins of specificity in protein-DNA recognition by Rohs, Remo, Jin, Xiangshu, West, Sean M, Joshi, Rohit, Honig, Barry, Mann, Richard S

“…Specific interactions between proteins and DNA are fundamental to many biological processes. In this review, we provide a revised view of protein-DNA…”
Get full text

Estrogen receptor β inhibits breast cancer cells migration and invasion through CLDN6-mediated autophagy by Song, Peiye, Li, Yanru, Dong, Yuan, Liang, Yingying, Qu, Huinan, Qi, Da, Lu, Yan, Jin, Xiangshu, Guo, Yantong, Jia, Yiyang, Wang, Xinqi, Xu, Wenhong, Quan, Chengshi

“…Estrogen receptor β (ERβ) has been reported to play an anti-cancer role in breast cancer, but the regulatory mechanism by which ERβ exerts this effect is not…”
Get full text

The Ankyrin Repeats of TRPV1 Bind Multiple Ligands and Modulate Channel Sensitivity by Lishko, Polina V., Procko, Erik, Jin, Xiangshu, Phelps, Christopher B., Gaudet, Rachelle

“…TRPV1 plays a key role in nociception, as it is activated by heat, low pH, and ligands such as capsaicin, leading to a burning pain sensation. We describe the…”
Get full text

The Extracellular Architecture of Adherens Junctions Revealed by Crystal Structures of Type I Cadherins by Harrison, Oliver J., Jin, Xiangshu, Hong, Soonjin, Bahna, Fabiana, Ahlsen, Goran, Brasch, Julia, Wu, Yinghao, Vendome, Jeremie, Felsovalyi, Klara, Hampton, Cheri M., Troyanovsky, Regina B., Ben-Shaul, Avinoam, Frank, Joachim, Troyanovsky, Sergey M., Shapiro, Lawrence, Honig, Barry

“…Adherens junctions, which play a central role in intercellular adhesion, comprise clusters of type I classical cadherins that bind via extracellular domains…”
Get full text

Gating of the TrkH ion channel by its associated RCK protein TrkA by Cao, Yu, Pan, Yaping, Huang, Hua, Jin, Xiangshu, Levin, Elena J., Kloss, Brian, Zhou, Ming

“…TrkH belongs to a superfamily of K + transport proteins required for growth of bacteria in low external K + concentrations. The crystal structure of TrkH from…”
Get full text

Cooperativity between trans and cis interactions in cadherin-mediated junction formation by Wu, Yinghao, Jin, Xiangshu, Harrison, Oliver, Shapiro, Lawrence, Honig, Barry H., Ben-Shaul, Avinoam

“…Intercellullar junctions formed by cadherins, including desmosomes and adherens junctions, comprise two dimensional arrays of "trans" dimers formed between…”
Get full text

The effect of whey protein on viral infection and replication of SARS-CoV-2 and pangolin coronavirus in vitro by Fan, Huahao, Hong, Bixia, Luo, Yuqian, Peng, Qi, Wang, Liqin, Jin, Xiangshu, Chen, Yangzhen, Hu, Yunjia, Shi, Yi, Li, Tong, Zhuang, Hui, Zhou, Yi-Hua, Tong, Yigang, Xiang, Kuanhui

Get full text

Clinical evaluation of an artificial intelligence-assisted cytological system among screening strategies for a cervical cancer high-risk population by Yang, Wen, Jin, Xiangshu, Huang, Liying, Jiang, Shufang, Xu, Jia, Fu, Yurong, Song, Yaoyao, Wang, Xueyan, Wang, Xueqing, Yang, Zhiming, Meng, Yuanguang

“…Primary cervical cancer screening and treating precancerous lesions are effective ways to prevent cervical cancer. However, the coverage rates of human…”
Get full text

Nectin ectodomain structures reveal a canonical adhesive interface by Harrison, Oliver J, Vendome, Jeremie, Brasch, Julia, Jin, Xiangshu, Hong, Soonjin, Katsamba, Phinikoula S, Ahlsen, Goran, Troyanovsky, Regina B, Troyanovsky, Sergey M, Honig, Barry, Shapiro, Lawrence

“…Nectins and nectin-like proteins promote intercellular adhesion and tissue patterning in vertebrates through homophilic or heterophilic interactions. Now the…”
Get full text

Elevated REG3α predicts refractory aGVHD in patients who received steroids-ruxolitinib as first-line therapy by Yang, Jingjing, Peng, Bo, Wang, Lu, Li, Xin, Li, Fei, Jin, Xiangshu, Jia, Mingyu, Xu, Lingmin, Dou, Liping, Liu, Daihong

“…We started a single-arm, phase II, open-label, prospective clinical trial using steroids-ruxolitinib as the first-line therapy for intermediate- to high-risk…”
Get full text

Structural and energetic determinants of adhesive binding specificity in type I cadherins by Vendome, Jeremie, Felsovalyi, Klara, Song, Hang, Yang, Zhongyu, Jin, Xiangshu, Brasch, Julia, Harrison, Oliver J., Ahlsen, Goran, Bahna, Fabiana, Kaczynska, Anna, Katsamba, Phinikoula S., Edmond, Darwin, Hubbell, Wayne L., Shapiro, Lawrence, Honig, Barry

“…Type I cadherin cell-adhesion proteins are similar in sequence and structure and yet are different enough to mediate highly specific cell-cell recognition…”
Get full text

Simultaneous occurrence of two distinct histotypes of ovarian endometriosis-associated cancer in bilateral ovaries: implications for monoclonal histogenesis from a case report by Zhao, Luyang, Liu, Yunyue, Liu, Feng, Jin, Xiangshu, Xu, Jia, Zhou, Shuting, Meng, Yuanguang, Liu, Aijun, Yang, Weng

“…Transformation of endometriosis to malignancy is a rare occurrence. Clear cell ovarian cancer and endometrioid ovarian cancer are the two histotypes most…”
Get full text

Survival outcomes of abdominal radical hysterectomy, laparoscopic radical hysterectomy, robot-assisted radical hysterectomy and vaginal radical hysterectomy approaches for early-stage cervical cancer: a retrospective study by Zhang, Nina, Jin, Xiangshu, Yang, Wen, Gu, Chenglei, Li, Li'an, Xu, Jia, Tang, Qiting, Fan, Wensheng, Meng, Yuanguang

“…This study compared the survival outcomes of abdominal radical hysterectomy (ARH) (N = 32), laparoscopic radical hysterectomy (LRH) (N = 61), robot-assisted…”
Get full text

Structure of the N-terminal Ankyrin Repeat Domain of the TRPV2 Ion Channel by Jin, Xiangshu, Touhey, Jason, Gaudet, Rachelle

“…The TRPV ion channels mediate responses to many sensory stimuli including heat, low pH, neuropeptides, and chemical ligands. All TRPV subfamily members contain…”
Get full text

OCT4 maintains self-renewal and reverses senescence in human hair follicle mesenchymal stem cells through the downregulation of p21 by DNA methyltransferases by Lu, Yan, Qu, Huinan, Qi, Da, Xu, Wenhong, Liu, Shutong, Jin, Xiangshu, Song, Peiye, Guo, Yantong, Jia, Yiyang, Wang, Xinqi, Li, Hairi, Li, Yulin, Quan, Chengshi

“…Self-renewal is dependent on an intrinsic gene regulatory network centered on OCT4 and on an atypical cell cycle G1/S transition, which is also regulated by…”
Get full text

DNA methylation of claudin-6 promotes breast cancer cell migration and invasion by recruiting MeCP2 and deacetylating H3Ac and H4Ac by Liu, Yafang, Jin, Xiangshu, Li, Yanru, Ruan, Yang, Lu, Yan, Yang, Minlan, Lin, Dongjing, Song, Peiye, Guo, Yantong, Zhao, Shuai, Dong, Bing, Xie, Yinping, Dang, Qihua, Quan, Chengshi

“…Claudin-6 (CLDN6), a member of claudin transmembrane protein family, has recently been reported to be undetectable or at low levels in human breast cancer cell…”
Get full text

Molecular basis of sidekick-mediated cell-cell adhesion and specificity by Goodman, Kerry M, Yamagata, Masahito, Jin, Xiangshu, Mannepalli, Seetha, Katsamba, Phinikoula S, Ahlsén, Göran, Sergeeva, Alina P, Honig, Barry, Sanes, Joshua R, Shapiro, Lawrence

“…Sidekick (Sdk) 1 and 2 are related immunoglobulin superfamily cell adhesion proteins required for appropriate synaptic connections between specific subtypes of…”
Get full text

Identification of 10 differentially expressed genes involved in the tumorigenesis of cervical cancer via next-generation sequencing by Xu, Jia, Yang, Wen, Xie, Xiufeng, Gu, Chenglei, Zhao, Luyang, Liu, Feng, Zhang, Nina, Bai, Yuge, Liu, Dan, Liu, Hainan, Jin, Xiangshu, Meng, Yuanguang

“…The incidence and mortality of cervical cancer remain high in female malignant tumors worldwide. There is still a lack of diagnostic and prognostic markers for…”
Get full text

SMAD2 Inactivation Inhibits CLDN6 Methylation to Suppress Migration and Invasion of Breast Cancer Cells by Lu, Yan, Wang, Liping, Li, Hairi, Li, Yanru, Ruan, Yang, Lin, Dongjing, Yang, Minlan, Jin, Xiangshu, Guo, Yantong, Zhang, Xiaoli, Quan, Chengshi

“…The downregulation of tight junction protein CLDN6 promotes breast cancer cell migration and invasion; however, the exact mechanism underlying CLDN6…”
Get full text

Crystal structure of a potassium ion transporter, TrkH by Cao, Yu, Jin, Xiangshu, Huang, Hua, Derebe, Mehabaw Getahun, Levin, Elena J., Kabaleeswaran, Venkataraman, Pan, Yaping, Punta, Marco, Love, James, Weng, Jun, Quick, Matthias, Ye, Sheng, Kloss, Brian, Bruni, Renato, Martinez-Hackert, Erik, Hendrickson, Wayne A., Rost, Burkhard, Javitch, Jonathan A., Rajashankar, Kanagalaghatta R., Jiang, Youxing, Zhou, Ming

“…The TrkH/TrkG/KtrB proteins mediate K + uptake in bacteria and probably evolved from simple K + channels by multiple gene duplications or fusions. Here we…”
Get full text