Search Results - "Jin, Wangrui"

A small molecule targeting myoferlin exerts promising anti-tumor effects on breast cancer by Zhang, Tao, Li, Jingjie, He, Yuan, Yang, Feifei, Hao, Yun, Jin, Wangrui, Wu, Jing, Sun, Zhenliang, Li, Yunqi, Chen, Yihua, Yi, Zhengfang, Liu, Mingyao

“…Breast cancer is one of the most lethal cancers in women when it reaches the metastatic stage. Here, we screen a library of small molecules for inhibitors of…”
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Inhibition of CDC25B With WG-391D Impedes the Tumorigenesis of Ovarian Cancer by Xiao, Yangjiong, Yu, Yang, Gao, Dan, Jin, Wangrui, Jiang, Pengcheng, Li, Yuhong, Wang, Chao, Song, Yuning, Zhan, Peng, Gu, Fei, Zhang, Cancan, Wang, Bin, Chen, Yihua, Du, Bing, Zhang, Rong

“…Novel inhibitors are urgently needed for use as targeted therapies to improve the overall survival (OS) of patients with ovarian cancer. Here, we show that…”
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Inhibition of HDACs-EphA2 Signaling Axis with WW437 Demonstrates Promising Preclinical Antitumor Activity in Breast Cancer by Zhang, Tao, Li, Jingjie, Ma, Xiaojun, Yang, Yang, Sun, Wei, Jin, Wangrui, Wang, Lei, He, Yuan, Yang, Feifei, Yi, Zhengfang, Hua, Yingqi, Liu, Mingyao, Chen, Yihua, Cai, Zhengdong

“…Histone deacetylase inhibitors (HDACi) are small molecules targeting epigenetic enzymes approved for hematologic neoplasms, which have also demonstrated…”
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Corrigendum to ‘Inhibition of HDACs-EphA2 signaling axis with WW437 demonstrates promising preclinical antitumor activity in breast cancer’ [EBioMedicine 31 (2018) 276–286] by Zhang, Tao, Li, Jingjie, Ma, Xiaojun, Yang, Yang, Sun, Wei, Jin, Wangrui, Wang, Lei, He, Yuan, Yang, Feifei, Yi, Zhengfang, Hua, Yingqi, Liu, Mingyao, Chen, Yihua, Cai, Zhengdong

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Update on the development of TGR5 agonists for human diseases by Jin, Wangrui, Zheng, Mingyue, Chen, Yihua, Xiong, Hai

“…The G protein-coupled bile acid receptor 1 (GPBAR1) or TGR5 is widely distributed across organs, including the small intestine, stomach, liver, spleen, and…”
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Discovery of 2‑Amino-3-cyanothiophene Derivatives as Potent STAT3 Inhibitors for the Treatment of Osteosarcoma Growth and Metastasis by Jin, Wangrui, Zhang, Tao, Zhou, Wenbo, He, Peng, Sun, Yue, Hu, Shijia, Chen, Huang, Ma, Xinglong, Peng, Yangrui, Yi, Zhengfang, Liu, Mingyao, Chen, Yihua

“…Osteosarcoma is one of the most common malignant bone tumors. However, the treatment and clinical outcomes of osteosarcoma have hardly changed over the past…”
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Discovery of a Novel Potent STAT3 Inhibitor HP590 with Dual p‑Tyr705/Ser727 Inhibitory Activity for Gastric Cancer Treatment by He, Peng, Miao, Ying, Sun, Yue, Bian, Aiwu, Jin, Wangrui, Chen, Huang, Ye, Jiangnan, He, Jia, Peng, Yangrui, Gu, Haijun, Liu, Mingyao, Yi, Zhengfang, Chen, Yihua

“…Accumulating evidence has documented that STAT3 phosphorylation at Tyr705 and Ser727 jointly promotes the initiation and progression of gastric cancer…”
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Discovery of a Highly Potent and Orally Bioavailable STAT3 Dual Phosphorylation Inhibitor for Pancreatic Cancer Treatment by He, Peng, Bian, Aiwu, Miao, Ying, Jin, Wangrui, Chen, Huang, He, Jia, Li, Liting, Sun, Yue, Ye, Jiangnan, Liu, Mingyao, Yi, Zhengfang, Zhou, Wenbo, Chen, Yihua

“…Increasing evidence has demonstrated that STAT3 phosphorylation at Tyr705 and Ser727 is closely associated with the progression and poor prognosis of…”
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Discovery of a Novel Potent STAT3 Inhibitor HP590 with Dual p-Tyr 705 /Ser 727 Inhibitory Activity for Gastric Cancer Treatment by He, Peng, Miao, Ying, Sun, Yue, Bian, Aiwu, Jin, Wangrui, Chen, Huang, Ye, Jiangnan, He, Jia, Peng, Yangrui, Gu, Haijun, Liu, Mingyao, Yi, Zhengfang, Chen, Yihua

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