Search Results - "Jin, Qihuang"

AF9 YEATS Domain Links Histone Acetylation to DOT1L-Mediated H3K79 Methylation by Li, Yuanyuan, Wen, Hong, Xi, Yuanxin, Tanaka, Kaori, Wang, Haibo, Peng, Danni, Ren, Yongfeng, Jin, Qihuang, Dent, Sharon Y.R., Li, Wei, Li, Haitao, Shi, Xiaobing

“…The recognition of modified histones by “reader” proteins constitutes a key mechanism regulating gene expression in the chromatin context. Compared with the…”
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DNA Sensing in Mismatch Repair-Deficient Tumor Cells Is Essential for Anti-tumor Immunity by Lu, Changzheng, Guan, Junhong, Lu, Steve, Jin, Qihuang, Rousseau, Benoit, Lu, Tianshi, Stephens, Dennis, Zhang, Hongyi, Zhu, Jiankun, Yang, Mingming, Ren, Zhenhua, Liang, Yong, Liu, Zhida, Han, Chuanhui, Liu, Longchao, Cao, Xuezhi, Zhang, Anli, Qiao, Jian, Batten, Kimberly, Chen, Mingyi, Castrillon, Diego H., Wang, Tao, Li, Bo, Diaz, Luis A., Li, Guo-Min, Fu, Yang-Xin

“…Increased neoantigens in hypermutated cancers with DNA mismatch repair deficiency (dMMR) are proposed as the major contributor to the high objective response…”
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UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity by Wang, Chaochen, Lee, Ji-Eun, Cho, Young-Wook, Xiao, Ying, Jin, Qihuang, Liu, Chengyu, Ge, Kai

“…To investigate the role of histone H3K27 demethylase UTX in embryonic stem (ES) cell differentiation, we have generated UTX knockout (KO) and enzyme-dead…”
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Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation by Jin, Qihuang, Yu, Li-Rong, Wang, Lifeng, Zhang, Zhijing, Kasper, Lawryn H, Lee, Ji-Eun, Wang, Chaochen, Brindle, Paul K, Dent, Sharon Y R, Ge, Kai

“…Histone acetyltransferases (HATs) GCN5 and PCAF (GCN5/PCAF) and CBP and p300 (CBP/p300) are transcription co‐activators. However, how these two distinct…”
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Histone H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis by Wang, Lifeng, Jin, Qihuang, Lee, Ji-Eun, Su, I. hsin, Ge, Kai

“…Wnt/β-catenin signaling inhibits adipogenesis. Genome-wide profiling studies have revealed the enrichment of histone H3K27 methyltransferase Ezh2 on Wnt genes…”
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High performance of targeted next generation sequencing on variance detection in clinical tumor specimens in comparison with current conventional methods by Su, Dan, Zhang, Dadong, Chen, Kaiyan, Lu, Jing, Wu, Junzhou, Cao, Xinkai, Ying, Lisha, Jin, Qihuang, Ye, Yizhou, Xie, Zhenghua, Xiong, Lei, Mao, Weimin, Li, Fugen

“…Next generation sequencing (NGS) is being increasingly applied for assisting cancer molecular diagnosis. However, it is still needed to validate NGS accuracy…”
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EZH2 Mediates Epigenetic Silencing of Neuroblastoma Suppressor Genes CASZ1, CLU, RUNX3, and NGFR by CHUNXI WANG, ZHIHUI LIU, KAI GE, THIELE, Carol J, WOO, Chan-Wook, ZHIJIE LI, LIFENG WANG, WEI, Jun S, MARQUEZ, Victor E, BATES, Susan E, QIHUANG JIN, KHAN, Javed

“…Neuroblastoma (NB) is the most common extracranial pediatric solid tumor with an undifferentiated status and generally poor prognosis, but the basis for these…”
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Cytoplasm-localized SIRT1 enhances apoptosis by Jin, Qihuang, Yan, Tingting, Ge, Xinjian, Sun, Cheng, Shi, Xianglin, Zhai, Qiwei

“…In general, SIRT1 is localized in nuclei. Here, we showed that endogenous and exogenous SIRT1 were both able to partially localize in cytoplasm in certain cell…”
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Promoter-bound p300 complexes facilitate post-mitotic transmission of transcriptional memory by Wong, Madeline M, Byun, Jung S, Sacta, Maria, Jin, Qihuang, Baek, SongJoon, Gardner, Kevin

“…A central hallmark of epigenetic inheritance is the parental transmission of changes in patterns of gene expression to progeny without modification of DNA…”
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Repurposing picropodophyllin as a potential thyroid eye disease treatment via delaying mitotic clonal expansion through a patient‐derived preclinical platform by Hu, Jing, Wu, Jiali, Jin, Qihuang, Zhang, Ling, Shen, Ning, Shu, Yiyang, Cheng, Lu, Zhang, Jian, Hu, Guangyi, Lv, Kangjia, Jian, Qizhi, Chen, Hui, Zhang, Fang, Sun, Xiaodong

“…Brightfield images and Bodipy staining showed similar formations of intracellular lipid droplets during adipogenic differentiation (Figures 1G,H and S2C),…”
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Matrine upregulates the cell cycle protein E2F-1 and triggers apoptosis via the mitochondrial pathway in K562 cells by Jiang, Hua, Hou, ChunHui, Zhang, ShuBing, Xie, HengYue, Zhou, WeiYing, Jin, QiHuang, Cheng, XiaoDong, Qian, RuoLan, Zhang, XueJun

“…Matrine is a major component of Sophora Flavescens and has been reported to stimulate differentiation of erythroleukemia cells. Here we show that matrine…”
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GSK3β mediates the induced expression of synaptic acetylcholinesterase during apoptosis by Jing, Peng, Jin, Qihuang, Wu, Jun, Zhang, Xue-Jun

“…Besides its role in terminating acetylcholine-mediated neurotransmission, acetylcholinesterase (AChE) is found to be expressed and participate in the process…”
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High glucose promotes IL-17A-induced gene expression through histone acetylation in retinal pigment epithelium cells by Wu, Jiali, Hu, Jing, Zhang, Fang, Jin, Qihuang, Sun, Xiaodong

“…•Diabetic retinopathy is the leading cause for working-age population. Previous works mostly focused on the abnormalities in retinal vasculature while we…”
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MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway by Guan, Junhong, Lu, Changzheng, Jin, Qihuang, Lu, Huiming, Chen, Xiang, Tian, Lei, Zhang, Yanbin, Ortega, Janice, Zhang, Junqiu, Siteni, Silvia, Chen, Mingyi, Gu, Liya, Shay, Jerry W., Davis, Anthony J., Chen, Zhijian J., Fu, Yang-Xin, Li, Guo-Min

“…Tumors with defective mismatch repair (dMMR) are responsive to immunotherapy because of dMMR-induced neoantigens and activation of the cGAS-STING pathway…”
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Single cell RNA sequencing (scRNA-Seq) deciphering pathological alterations in streptozotocin-induced diabetic retinas by Sun, Licheng, Wang, Ruonan, Hu, Guangyi, Liu, Huazhen, Lv, Kangjia, Duan, Yi, Shen, Ning, Wu, Jiali, Hu, Jing, Liu, Yujuan, Jin, Qihuang, Zhang, Fang, Xu, Xun

“…Diabetic retinopathy (DR) is an irreversible and progressive diabetic complication leading to visual impairment, even blindness. Due to the delicate and…”
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PCAF Acetylates β-Catenin and Improves Its Stability by Ge, Xinjian, Jin, Qihuang, Zhang, Fang, Yan, Tingting, Zhai, Qiwei

“…β-Catenin plays an important role in development and tumorigenesis. However, the effect of a key acetyltransferase p300/CBP-associated factor (PCAF) on…”
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Gcn5 and PCAF Regulate PPARγ and Prdm16 Expression To Facilitate Brown Adipogenesis by Jin, Qihuang, Wang, Chaochen, Kuang, Xianghong, Feng, Xuesong, Sartorelli, Vittorio, Ying, Hao, Ge, Kai, Dent, Sharon Y. R.

“…The acetyltransferase Gcn5 is critical for embryogenesis and shows partial functional redundancy with its homolog PCAF. However, the tissue- and cell…”
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Histone Methylation Regulator PTIP Is Required for PPARγ and C/EBPα Expression and Adipogenesis by Cho, Young-Wook, Hong, SunHwa, Jin, Qihuang, Wang, Lifeng, Lee, Ji-Eun, Gavrilova, Oksana, Ge, Kai

“…PPARγ and C/EBPα cooperate to control preadipocyte differentiation (adipogenesis). However, the factors that regulate PPARγ and C/EBPα expression during…”
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MLH1 Deficiency-Triggered DNA Hyper-Excision by Exonuclease 1 Activates the cGAS-STING Pathway by Guan, Junhong, Lu, Changzheng, Jin, Qihuang, Lu, Huiming, Chen, Xiang, Tian, Lei, Zhang, Yanbin, Ortega, Janice, Zhang, Junqiu, Siteni, Silvia, Chen, Mingyi, Gu, Liya, Shay, Jerry W., Davis, Anthony J., Chen, Zhijian J., Fu, Yang-Xin, Li, Guo-Min

“…Tumors with defective mismatch repair (dMMR) are responsive to immunotherapy because of dMMR-induced neoantigens and activation of the cGAS-STING pathway…”
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C/EBPα regulates SIRT1 expression during adipogenesis by Jin, Qihuang, Zhang, Fang, Yan, Tingting, Liu, Zhen, Wang, Chunxi, Ge, Xinjian, Zhai, Qiwei

“…SIRT1 plays an important role in adipogenesis, but how SIRT1 is regulated in adipogenesis is largely unknown. In this study, we show that both SIRT1 protein…”
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