Search Results - "Jin, Denan"

Chymase as a Possible Therapeutic Target for Amelioration of Non-Alcoholic Steatohepatitis by Takai, Shinji, Jin, Denan

“…The development and progression of non-alcoholic steatohepatitis (NASH) are linked to oxidative stress, inflammation, and fibrosis of the liver. Chymase, a…”
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In Vivo and In Vitro Evaluation of Urinary Biomarkers in Ischemia/Reperfusion-Induced Kidney Injury by Hosohata, Keiko, Jin, Denan, Takai, Shinji

“…Oxidative stress plays an important role in the pathophysiology of acute kidney injury (AKI). Previously, we reported that vanin-1, which is involved in…”
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Glaucocalyxin A Ameliorates Hypoxia/Reoxygenation-Induced Injury in Human Renal Proximal Tubular Epithelial Cell Line HK-2 Cells by Hosohata, Keiko, Jin, Denan, Takai, Shinji

“…Ischemia-reperfusion injury is one of the major causes of acute kidney injury (AKI), which is increasingly prevalent in clinical settings. Glaucocalxin A…”
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Tryptase-Positive Mast Cells Promote Adipose Fibrosis in Secondary Lymphedema through PDGF by Nuri, Takashi, Jin, Denan, Takai, Shinji, Ueda, Koichi

“…Lymphedema is a chronic and progressive condition that causes physical disfigurement and psychological trauma due to the accumulation of lymphatic fluid in the…”
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Pathophysiological Role of Chymase-Activated Matrix Metalloproteinase-9 by Takai, Shinji, Jin, Denan

“…Chymase present in mast cells can directly form matrix metalloproteinase (MMP)-9 from proMMP-9. Chymase-activated MMP-9 has been reportedly closely related to…”
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Involvement of Vanin-1 in Ameliorating Effect of Oxidative Renal Tubular Injury in Dahl-Salt Sensitive Rats by Hosohata, Keiko, Jin, Denan, Takai, Shinji, Iwanaga, Kazunori

“…In salt-sensitive hypertension, reactive oxygen species (ROS) play a major role in the progression of renal disease partly through the activation of the…”
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Hypermetabolism of glutathione, glutamate and ornithine via redox imbalance in methylglyoxal-induced peritoneal injury rats by Hirahara, Ichiro, Kusano, Eiji, Jin, Denan, Takai, Shinji

“…Abstract Peritoneal dialysis (PD) is a blood purification treatment for patients with reduced renal function. However, the peritoneum is exposed to oxidative…”
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Vanin-1 in Renal Pelvic Urine Reflects Kidney Injury in a Rat Model of Hydronephrosis by Hosohata, Keiko, Jin, Denan, Takai, Shinji, Iwanaga, Kazunori

“…Urinary tract obstruction and the subsequent development of hydronephrosis can cause kidney injuries, which results in chronic kidney disease. Although it is…”
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Blastocyst-like Structures in the Peripheral Retina of Young Adult Beagles by Ikeda, Tsunehiko, Jin, Denan, Takai, Shinji, Nakamura, Kimitoshi, Nemoto, Emika, Kojima, Shota, Oku, Hidehiro

“…In this immunohistological study on the peripheral retina of 3-year-old beagle dogs, excised retina specimens were immunostained with antibodies against…”
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Significance of Vascular Dipeptidyl Peptidase-4 Inhibition on Vascular Protection in Zucker Diabetic Fatty Rats by Takai, Shinji, Sakonjo, Hiroshi, Jin, Denan

“…To clarify the role of dipeptidyl peptidase-4 (DPP-4) inhibition in vascular tissues, we compared the effects of the poorly tissue-penetrative DPP-4 inhibitor…”
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Early urinary biomarkers of renal tubular damage by a high‐salt intake independent of blood pressure in normotensive rats by Washino, Satoshi, Hosohata, Keiko, Jin, Denan, Takai, Shinji, Miyagawa, Tomoaki

“…Summary Dietary sodium intake has been associated with progression to chronic kidney disease (CKD) as well as hypertension. A high‐salt intake causes renal…”
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Chymase Inhibitor as a Novel Therapeutic Agent for Non-alcoholic Steatohepatitis by Takai, Shinji, Jin, Denan

“…Non-alcoholic steatohepatitis (NASH) is characterized by inflammation and fibrosis, in addition to steatosis, of the liver, but no therapeutic agents have yet…”
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Activation of Mast-Cell-Derived Chymase in the Lacrimal Glands of Patients with IgG4-Related Ophthalmic Disease by Fujita, Yasushi, Jin, Denan, Mimura, Masashi, Sato, Yohei, Takai, Shinji, Kida, Teruyo

“…The purpose of this present study was to investigate the distribution and expression of chymase in the lacrimal glands (LGs) of patients afflicted with…”
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Increase in Chymase-Positive Mast Cells in Recurrent Pleomorphic Adenoma and Carcinoma Ex Pleomorphic Adenoma of the Parotid Gland by Kinoshita, Ichita, Jin, Denan, Higashino, Masaaki, Terada, Tetsuya, Kurisu, Yoshitaka, Takai, Shinji, Kawata, Ryo

“…Incomplete excision of pleomorphic adenoma (PA) may result in recurrent pleomorphic adenoma (RPA). Furthermore, long-term neglected PA may become carcinoma ex…”
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Increased Chymase-Positive Mast Cells in High-Grade Mucoepidermoid Carcinoma of the Parotid Gland by Nishimura, Hiromi, Jin, Denan, Kinoshita, Ichita, Taniuchi, Masataka, Higashino, Masaaki, Terada, Tetsuya, Takai, Shinji, Kawata, Ryo

“…It has long been known that high-grade mucoepidermoid carcinoma (MEC) has a poor prognosis, but the detailed molecular and biological mechanisms underlying…”
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Chymase as a Novel Therapeutic Target in Acute Pancreatitis by Kuramoto, Toru, Jin, Denan, Komeda, Koji, Taniguchi, Kohei, Hirokawa, Fumitoshi, Takai, Shinji, Uchiyama, Kazuhisa

“…Acute pancreatitis is still a life-threatening disease without an evidenced therapeutic agent. In this study, the effect of chymase in acute pancreatitis and…”
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The novel mechanism of valproate to prevent peritoneal adhesion formation by Liu, Shuangping, Liu, Liping, Jin, Denan, Zhang, Qinggao, Takai, Shinji

“…Purpose A novel pharmacological mechanism of valproate was analyzed using a hamster model of adhesion. Methods Valproate or placebo was administered just after…”
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Mechanism of Albuminuria Reduction by Chymase Inhibition in Diabetic Mice by Terai, Kentaro, Jin, Denan, Watase, Kenji, Imagawa, Akihisa, Takai, Shinji

“…Chymase has several functions, such as angiotensin II formation, which can promote diabetic kidney disease (DKD). In this study, we evaluated the effect of the…”
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Multiple Mechanisms for the Action of Chymase Inhibitors by Takai, Shinji, Jin, Denan, Miyazaki, Mizuo

“…Angiotensin II plays an important role in regulating blood pressure. Moreover, angiotensin II directly promotes organ damage by inducing expression of various…”
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Involvement of premacular mast cells in the pathogenesis of macular diseases by Sato, Takaki, Morishita, Seita, Horie, Taeko, Fukumoto, Masanori, Kida, Teruyo, Oku, Hidehiro, Nakamura, Kimitoshi, Takai, Shinji, Jin, Denan, Ikeda, Tsunehiko

“…We previously reported on the elevated intravitreal activities of tryptase and chymase in association with idiopathic epiretinal membrane (ERM) and idiopathic…”
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