Search Results - "Jin, Debi"

Discovery of the pan-genotypic hepatitis C virus NS3/4A protease inhibitor voxilaprevir (GS-9857): A component of Vosevi by Taylor, James G., Zipfel, Sheila, Ramey, Kyla, Vivian, Randy, Schrier, Adam, Karki, Kapil K., Katana, Ashley, Kato, Darryl, Kobayashi, Tetsuya, Martinez, Ruben, Sangi, Michael, Siegel, Dustin, Tran, Chinh V., Yang, Zheng-Yu, Zablocki, Jeff, Yang, Cheng Y., Wang, Yujin, Wang, Kelly, Chan, Katie, Barauskas, Ona, Cheng, Guofeng, Jin, Debi, Schultz, Brian E., Appleby, Todd, Villaseñor, Armando G., Link, John O.

“…[Display omitted] Treatment of hepatitis C virus (HCV) infection has been historically challenging due the high viral genetic complexity wherein there are…”
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A Trimer of Dimers Is the Basic Building Block for Human Immunodeficiency Virus-1 Capsid Assembly by Tsiang, Manuel, Niedziela-Majka, Anita, Hung, Magdeleine, Jin, Debi, Hu, Eric, Yant, Stephen, Samuel, Dharmaraj, Liu, Xiaohong, Sakowicz, Roman

“…Human immunodeficiency virus-1 (HIV-1) capsid protein (CA) has become a target of antiviral drug design in recent years. The recognition that binding of small…”
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Inhibition of Hepatitis C Virus Replication by GS-6620, a Potent C-Nucleoside Monophosphate Prodrug by FENG, Joy Y, GUOFENG CHENG, YANG TIAN, LEE, Yu-Jen, STEPAN, George, LAGPACAN, Leanna L, DEBI JIN, HUNG, Magdeleine, KU, Karin S, BIN HAN, KITRINOS, Kathryn, PERRON, Michel, PERRY, Jason, BIRKUS, Gabriel, WONG, Kelly A, WEIDONG ZHONG, KIM, Choung U, CAREY, Anne, AESOP CHO, RAY, Adrian S, BARAUSKAS, Ona, YILI XU, FENAUX, Martijn, ENG, Stacey, TIRUNAGARI, Neeraj, BETTY PENG, MEI YU

“…As a class, nucleotide inhibitors (NIs) of the hepatitis C virus (HCV) nonstructural protein 5B (NS5B) RNA-dependent RNA polymerase offer advantages over other…”
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Large-scale functional purification of recombinant HIV-1 capsid by Hung, Magdeleine, Niedziela-Majka, Anita, Jin, Debi, Wong, Melanie, Leavitt, Stephanie, Brendza, Katherine M, Liu, Xiaohong, Sakowicz, Roman

“…During human immunodeficiency virus type-1 (HIV-1) virion maturation, capsid proteins undergo a major rearrangement to form a conical core that protects the…”
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Functional Label-Free Assays for Characterizing the in Vitro Mechanism of Action of Small Molecule Modulators of Capsid Assembly by Lad, Latesh, Clancy, Sheila, Koditek, David, Wong, Melanie H, Jin, Debi, Niedziela-Majka, Anita, Papalia, Giuseppe A, Hung, Magdeleine, Yant, Stephen, Somoza, John R, Hu, Eric, Chou, Chienhung, Tse, Winston, Halcomb, Randall, Sakowicz, Roman, Pagratis, Nikos

“…HIV capsid protein is an important target for antiviral drug design. High-throughput screening campaigns have identified two classes of compounds (PF74 and…”
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A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model by Yant, Stephen R., Mulato, Andrew, Hansen, Derek, Tse, Winston C., Niedziela-Majka, Anita, Zhang, Jennifer R., Stepan, George J., Jin, Debi, Wong, Melanie H., Perreira, Jill M., Singer, Eric, Papalia, Giuseppe A., Hu, Eric Y., Zheng, Jim, Lu, Bing, Schroeder, Scott D., Chou, Kevin, Ahmadyar, Shekeba, Liclican, Albert, Yu, Helen, Novikov, Nikolai, Paoli, Eric, Gonik, Daniel, Ram, Renee R., Hung, Magdeleine, McDougall, William M., Brass, Abraham L., Sundquist, Wesley I., Cihlar, Tomas, Link, John O.

“…People living with HIV (PLWH) have expressed concern about the life-long burden and stigma associated with taking pills daily and can experience medication…”
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Crystal Structures of HIV-1 Reverse Transcriptase with Etravirine (TMC125) and Rilpivirine (TMC278): Implications for Drug Design by Lansdon, Eric B, Brendza, Katherine M, Hung, Magdeleine, Wang, Ruth, Mukund, Susmith, Jin, Debi, Birkus, Gabriel, Kutty, Nilima, Liu, Xiaohong

“…Diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitors (NNRTIs) have inherent flexibility, helping to maintain activity against a wide range…”
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Flt3 agonist enhances immunogenicity of arenavirus vector-based simian immunodeficiency virus vaccine in macaques by Boopathy, Archana Vidya, Nekkalapudi, Anurag, Sung, Janette, Schulha, Sophie, Jin, Debi, Sharma, Bhawna, Ng, Sarah, Lu, Sabrina, Wimmer, Raphaela, Suthram, Silpa, Ahmadi-Erber, Sarah, Lauterbach, Henning, Orlinger, Klaus K, Hung, Magdeleine, Carr, Brian, Callebaut, Christian, Geleziunas, Romas, Kuhne, Michelle, Schmidt, Sarah, Falkard, Brie

“…Arenaviral vaccine vectors encoding simian immunodeficiency virus (SIV) immunogens are capable of inducing efficacious humoral and cellular immune responses in…”
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Discovery of Potent Cyclophilin Inhibitors Based on the Structural Simplification of Sanglifehrin A by Steadman, Victoria A, Pettit, Simon B, Poullennec, Karine G, Lazarides, Linos, Keats, Andrew J, Dean, David K, Stanway, Steven J, Austin, Carol A, Sanvoisin, Jonathan A, Watt, Gregory M, Fliri, Hans G, Liclican, Albert C, Jin, Debi, Wong, Melanie H, Leavitt, Stephanie A, Lee, Yu-Jen, Tian, Yang, Frey, Christian R, Appleby, Todd C, Schmitz, Uli, Jansa, Petr, Mackman, Richard L, Schultz, Brian E

“…Cyclophilin inhibition has been a target for the treatment of hepatitis C and other diseases, but the generation of potent, drug-like molecules through…”
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Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor by Sperandio, David, Aktoudianakis, Vangelis, Babaoglu, Kerim, Chen, Xiaowu, Elbel, Kristyna, Chin, Gregory, Corkey, Britton, Du, Jinfa, Jiang, Bob, Kobayashi, Tetsuya, Mackman, Richard, Martinez, Ruben, Yang, Hai, Zablocki, Jeff, Kusam, Saritha, Jordan, Kim, Webb, Heather, Bates, Jamie G., Lad, Latesh, Mish, Michael, Niedziela-Majka, Anita, Metobo, Sammy, Sapre, Annapurna, Hung, Magdeleine, Jin, Debi, Fung, Wanchi, Kan, Elaine, Eisenberg, Gene, Larson, Nate, Newby, Zachary E.R., Lansdon, Eric, Tay, Chin, Neve, Richard M., Shevick, Sophia L., Breckenridge, David G.

“…[Display omitted] •The structure-guided discovery of a novel BET bromodomain inhibitor is disclosed.•The lead properties were optimized using in-vitro assays…”
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Combination Therapy of Selective MMP9 Inhibitor and JAK Inhibitor Is Effective to Induce Disease Control in Mouse DSS Model of Colitis: 593 by Kim, Sunhwa, Carr, Brian, Tong, Leah, Sobczyk, Monika, Zheng, Jim, Lu, Bing, Mikaelian, Igor, Brockett, Robert, Jin, Debi, Wang, Ruth, Kanwar, Bittoo, Smith, Victoria

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Binding kinetics, potency, and selectivity of the hepatitis C virus NS3 protease inhibitors GS-9256 and vedroprevir by Barauskas, Ona, Corsa, Amoreena C., Wang, Ruth, Hluhanich, Scott, Jin, Debi, Hung, Magdeleine, Yang, Huiling, Delaney, William E., Schultz, Brian E.

“…GS-9256 and vedroprevir are inhibitors of the hepatitis C virus NS3 protease enzyme, an important drug target. The potency, selectivity, and binding kinetics…”
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Dithiothreitol Causes HIV-1 Integrase Dimer Dissociation While Agents Interacting With the Integrase Dimer Interface Promote Dimer Formation by Tsiang, Manuel, Jones, Gregg S, Hung, Magdeleine, Samuel, Dharmaraj, Novikov, Nikolai, Mukund, Susmith, Brendza, Katherine M, Niedziela-Majka, Anita, Jin, Debi, Liu, Xiaohong, Mitchell, Michael, Sakowicz, Roman, Geleziunas, Romas

“…We have developed a homogeneous time-resolved fluorescence resonance energy transfer (FRET)-based assay that detects the formation of HIV-1 integrase (IN)…”
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Lipid Sensing Apolipoprotein A-I for Novel High-Throughput Lipidation Assays by Niedziela-Majka, Anita, Lad, Latesh, Chishom, Jeffrey W., Lagpacan, Leanna, Schwartz, Karen, Hung, Magdeleine, Jin, Debi, Fung, Wanchi, Brendza, Katherine M., Liu, Xioahong, Pagratis, Nikos, Sakowicz, Roman

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Lipid-sensing high-throughput ApoA-I assays by Niedziela-Majka, Anita, Lad, Latesh, Chisholm, Jeffrey W, Lagpacan, Leanna, Schwartz, Karen, Hung, Magdeleine, Jin, Debi, Fung, Wanchi, Brendza, Katherine M, Liu, Xiaohong, Pagratis, Nikos, Sakowicz, Roman

“…Apolipoprotein A-I (ApoA-I), a primary protein component of high-density lipoprotein (HDL), plays an important role in cholesterol metabolism mediating the…”
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Large-Scale Functional Purification of Recombinant HIV-1 Capsid. e58035 by Hung, Magdeleine, Niedziela-Majka, Anita, Jin, Debi, Wong, Melanie, Leavitt, Stephanie, Brendza, Katherine M, Liu, Xiaohong, Sakowicz, Roman

“…During human immunodeficiency virus type-1 (HIV-1) virion maturation, capsid proteins undergo a major rearrangement to form a conical core that protects the…”
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