Search Results - "Jin, Byung Kwan"

Norfluoxetine Prevents Degeneration of Dopamine Neurons by Inhibiting Microglia-Derived Oxidative Stress in an MPTP Mouse Model of Parkinson’s Disease by Kim, Kyung In, Jin, Byung Kwan, Chung, Young Cheul

“…Neuroinflammation is the neuropathological feature of Parkinson’s disease (PD) and causes microglial activation and activated microglia-derived oxidative…”
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Interleukin-10 endogenously expressed in microglia prevents lipopolysaccharide-induced neurodegeneration in the rat cerebral cortex in vivo by Park, Keun Woo, Lee, Hwan Goo, Jin, Byung Kwan, Lee, Yong Beom

“…A degree of brain inflammation is required for repair of damaged tissue, but excessive inflammation causes neuronal cell death. Here, we observe that IL-10 is…”
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Interleukin-13 Enhances Cyclooxygenase-2 Expression in Activated Rat Brain Microglia: Implications for Death of Activated Microglia by Yang, Myung-Soon, Ji, Kyung-Ae, Jeon, Sae-Bom, Jin, Byung-Kwan, Kim, Seung U, Jou, Ilo, Joe, Eunhye

“…Brain inflammation has recently attracted widespread interest because it is a risk factor for the onset and progression of brain diseases. In this study, we…”
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Simplified Heterocyclic Analogues of Fluoxetine Inhibit Inducible Nitric Oxide Production in Lipopolysaccharide-Induced BV2 Cells by Park, Ju-Young, Kim, Seung-Woo, Lee, Ja-Kyeong, Im, Weon Bin, Jin, Byung Kwan, Yoon, Sung-Hwa

“…A series of fluoxetine, where the N-methylamino group was replaced and then simplified, were synthesized and their inhibitory effect was tested for nitric…”
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Prevention of Nitric Oxide-Mediated 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Parkinson’s Disease in Mice by Tea Phenolic Epigallocatechin 3-Gallate by Choi, Ji-Young, Park, Chang-Shin, Kim, Dae-Joong, Cho, Myung-Haeng, Jin, Byung-Kwan, Pie, Jae-Eun, Chung, Woon-Gye

“…In animal models of Parkinson’s disease (PD), the toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is mediated by oxidative stress, especially…”
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Impact of Several Types of Stresses on Short-term Memory and Apoptosis in the Hippocampus of Rats by Kim, Bo-Kyun, Ko, Il-Gyu, Kim, Sung-Eun, Kim, Chang-Ju, Yoon, Jee-Sang, Baik, Hyung-Hwan, Jin, Byung-Kwan, Lee, Choong-Yeol, Baek, Sang-Bin, Shin, Mal-Soon

“…Stress has a deteriorating effect on hippocampal function. It also contributes to symptom exacerbation in many disease states, including overactive bladder and…”
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Inflachromene ameliorates Parkinson's disease by targeting Nrf2-binding Keap1 by Yim, Junhyeong, Hwang, Yoon Soo, Lee, Jae-Jin, Kim, Ju Hee, Baek, Jeong Yeob, Jeong, Jaeyeong, Choi, Young Il, Jin, Byung Kwan, Park, Seung Bum

“…Parkinson's disease (PD) is the most common neurodegenerative disease characterized by movement disorder. Despite current therapeutic efforts, PD progression…”
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Modulation of M1/M2 polarization by capsaicin contributes to the survival of dopaminergic neurons in the lipopolysaccharide-lesioned substantia nigra in vivo by Bok, Eugene, Chung, Young Cheul, Kim, Ki-Suk, Baik, Hyung Hwan, Shin, Won-Ho, Jin, Byung Kwan

“…The present study examined the neuroprotective effects of capsaicin (CAP) and explored their underlying mechanisms in a lipopolysaccharide (LPS)-lesioned…”
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Interleukin-4 and Interleukin-13 Exacerbate Neurotoxicity of Prothrombin Kringle-2 in Cortex In Vivo via Oxidative Stress by Jeong, Jae Yeong, Chung, Young Cheul, Jin, Byung Kwan

“…The present study investigated the effects of activated microglia-derived interleukin-4 (IL-4) and IL-13 on neurodegeneration in prothrombin kringle-2…”
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Interleukin-13 Propagates Prothrombin Kringle-2-Induced Neurotoxicity in Hippocampi In Vivo via Oxidative Stress by Jeong, Jae Yeong, Wi, Rayul, Chung, Young Cheul, Jin, Byung Kwan

“…The present study investigated expression of endogenous interleukin-13 (IL-13) and its possible function in the hippocampus of prothrombin kringle-2…”
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p70S6K on astrocytes protects dopamine neurons from 1‐methyl‐4‐phenylpyridinium neurotoxicity by Kim, Kyoung In, Baek, Jeong Yeob, Chung, Young Cheul, Nam, Jin Han, Shin, Won‐Ho, Jin, Byung Kwan

“…Our recent finding has demonstrated that astrocytes confer neuroprotection by endogenously producing ciliary neurotrophic factor (CNTF) via transient receptor…”
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Functional Crosstalk between CB and TRPV1 Receptors Protects Nigrostriatal Dopaminergic Neurons in the MPTP Model of Parkinson’s Disease by Wi, Rayul, Jin, Byung Kwan, Chung, Young Cheul

“…The present study examined whether crosstalk between cannabinoid (CB) and transient potential receptor vanilloid type 1 (TRPV1) could contribute to the…”
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Cannabinoids prevent lipopolysaccharide-induced neurodegeneration in the rat substantia nigra in vivo through inhibition of microglial activation and NADPH oxidase by Chung, Eun Sook, Bok, Eugene, Chung, Young Cheul, Baik, Hyung Hwan, Jin, Byung Kwan

“…Abstract We investigated the effects of synthetic cannabinoids, WIN55,212-2 and HU210, on LPS-injected rat substantia nigra in vivo. Intranigral injection of…”
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Control of hippocampal prothrombin kringle‐2 (pKr‐2) expression reduces neurotoxic symptoms in five familial Alzheimer's disease mice by Kim, Sehwan, Moon, Gyeong Joon, Kim, Hyung Jun, Kim, Do‐Geun, Kim, Jaekwang, Nam, Youngpyo, Sharma, Chanchal, Leem, Eunju, Lee, Shinrye, Kim, Kyu‐Sung, Ha, Chang Man, McLean, Catriona, Jin, Byung Kwan, Shin, Won‐Ho, Kim, Dong Woon, Oh, Yong‐Seok, Hong, Chang‐Won, Kim, Sang Ryong

“…Background and Purpose There is a scarcity of information regarding the role of prothrombin kringle‐2 (pKr‐2), which can be generated by active thrombin, in…”
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Induction of GDNF and BDNF by hRheb(S16H) Transduction of SNpc Neurons: Neuroprotective Mechanisms of hRheb(S16H) in a Model of Parkinson’s Disease by Nam, Jin Han, Leem, Eunju, Jeon, Min-Tae, Jeong, Kyoung Hoon, Park, Jeen-Woo, Jung, Un Ju, Kholodilov, Nikolai, Burke, Robert E., Jin, Byung Kwan, Kim, Sang Ryong

“…The transduction of dopaminergic (DA) neurons with human ras homolog enriched in brain, which has a S16H mutation [hRheb(S16H)] protects the nigrostriatal DA…”
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Activation of CNTF/CNTFRα signaling pathway by hRheb(S16H) transduction of dopaminergic neurons in vivo by Jeong, Kyoung Hoon, Nam, Jin Han, Jin, Byung Kwan, Kim, Sang Ryong

“…Ciliary neurotrophic factor (CNTF) is one of representative neurotrophic factors for the survival of dopaminergic neurons. Its effects are primarily mediated…”
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Naringin protects the nigrostriatal dopaminergic projection through induction of GDNF in a neurotoxin model of Parkinson's disease by Leem, Eunju, Nam, Jin Han, Jeon, Min-Tae, Shin, Won-Ho, Won, So-Yoon, Park, Sang-Joon, Choi, Myung-Sook, Jin, Byung Kwan, Jung, Un Ju, Kim, Sang Ryong

“…This study investigated the effect of naringin, a major flavonoid in grapefruit and citrus fruits, on the degeneration of the nigrostriatal dopaminergic (DA)…”
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Induction of microglial toll-like receptor 4 by prothrombin kringle-2: a potential pathogenic mechanism in Parkinson’s disease by Shin, Won-Ho, Jeon, Min-Tae, Leem, Eunju, Won, So-Yoon, Jeong, Kyoung Hoon, Park, Sang-Joon, McLean, Catriona, Lee, Sung Joong, Jin, Byung Kwan, Jung, Un Ju, Kim, Sang Ryoung

“…Microglia-mediated neuroinflammation may play an important role in the initiation and progression of dopaminergic (DA) neurodegeneration in Parkinson’s disease…”
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p21-activated kinase 4 controls the aggregation of α-synuclein by reducing the monomeric and aggregated forms of α-synuclein: involvement of the E3 ubiquitin ligase NEDD4-1 by Won, So-Yoon, Park, Jung-Jin, You, Soon-Tae, Hyeun, Jong-A, Kim, Hyong-Kyu, Jin, Byung Kwan, McLean, Catriona, Shin, Eun-Young, Kim, Eung-Gook

“…Aggregation of misfolded alpha-synuclein (α-synuclein) is a central player in the pathogenesis of neurodegenerative diseases. Therefore, the regulatory…”
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Inhibition of Microglia-Derived Oxidative Stress by Ciliary Neurotrophic Factor Protects Dopamine Neurons In Vivo from MPP⁺ Neurotoxicity by Baek, Jeong Yeob, Jeong, Jae Yeong, Kim, Kyoung In, Won, So-Yoon, Chung, Young Cheul, Nam, Jin Han, Cho, Eun Ju, Ahn, Tae-Beom, Bok, Eugene, Shin, Won-Ho, Jin, Byung Kwan

“…We demonstrated that capsaicin (CAP), an agonist of transient receptor potential vanilloid subtype 1 (TRPV1), inhibits microglia activation and…”
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