Search Results - "Jimenez Blanco, Jose L"

Molecular nanoparticle-based gene delivery systems by Jiménez Blanco, José L., Benito, Juan M., Ortiz Mellet, Carmen, García Fernández, José M.

“…The last years have witnessed an impressive development of material sciences following the burst of nanotechnology, which has greatly contributed to the…”
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Multivalency in heterogeneous glycoenvironments: hetero-glycoclusters, -glycopolymers and -glycoassemblies by Jiménez Blanco, José L, Ortiz Mellet, Carmen, García Fernández, José M

“…Despite efficiently imitating functional ligand presentations in terms of valency and density, most of the reported multivalent carbohydrate prototypes barely…”
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Extending the Scope of the C‑Functionalization of Cyclam via Copper(I)-Catalyzed Alkyne–Azide Cycloaddition to Bifunctional Chelators of Interest by Ollier, Cédric, Méndez-Ardoy, Alejandro, Ortega-Caballero, Fernando, Jiménez-Blanco, José L., Le Bris, Nathalie, Tripier, Raphaël

“…Cyclam, known for its potent chelation properties, is explored for diverse applications through selective N-functionalization, offering versatile ligands for…”
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Mannosyl-coated nanocomplexes from amphiphilic cyclodextrins and pDNA for site-specific gene delivery by Díaz-Moscoso, Alejandro, Guilloteau, Nicolas, Bienvenu, Céline, Méndez-Ardoy, Alejandro, Jiménez Blanco, José L, Benito, Juan M, Le Gourriérec, Loïc, Di Giorgio, Christophe, Vierling, Pierre, Defaye, Jacques, Ortiz Mellet, Carmen, García Fernández, José M

“…Abstract Fully homogeneous facial amphiphiles consisting in a cyclodextrin (CD) platform onto which a polycationic cluster and a multi-tail hydrophobic moiety…”
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Click Synthesis of Size- and Shape-Tunable Star Polymers with Functional Macrocyclic Cores for Synergistic DNA Complexation and Delivery by Carbajo-Gordillo, Ana I, Jiménez Blanco, José L, Benito, Juan M, Lana, Hugo, Marcelo, Gema, Di Giorgio, Christophe, Przybylski, Cédric, Hinou, Hiroshi, Ceña, Valentín, Ortiz Mellet, Carmen, Mendicuti, Francisco, Tros de Ilarduya, Conchita, García Fernández, José M

“…The architectural perfection and multivalency of dendrimers have made them useful for biodelivery via peripheral functionalization and the adjustment of…”
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Probing Carbohydrate-Lectin Recognition in Heterogeneous Environments with Monodisperse Cyclodextrin-Based Glycoclusters by Gómez-García, Marta, Benito, Juan M, Butera, Anna P, Mellet, Carmen Ortiz, Fernández, José M. García, Blanco, José L. Jiménez

“…A series of β-cyclodextrin (βCD)-scaffolded glycoclusters exposing heterogeneous yet perfectly controlled displays of α-mannosyl (α-Man) and β-lactosyl…”
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A β-Cyclodextrin-Based Nanoparticle with Very High Transfection Efficiency Unveils siRNA-Activated TLR3 Responses in Human Prostate Cancer Cells by de la Torre, Cristina, Játiva, Pablo, Posadas, Inmaculada, Manzanares, Darío, Blanco, José L. Jiménez, Mellet, Carmen Ortiz, Fernández, José Manuel García, Ceña, Valentín

“…Synthetic double-stranded small interfering RNAs (siRNAs) mimic interference RNAs (RNAi) and can bind target mRNAs with a high degree of specificity, leading…”
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Amphiphilic Oligoethyleneimine−β-Cyclodextrin “Click” Clusters for Enhanced DNA Delivery by Martínez, Álvaro, Bienvenu, Céline, Jiménez Blanco, José L, Vierling, Pierre, Mellet, Carmen Ortiz, García Fernández, José M, Di Giorgio, Christophe

“…Monodisperse amphiphilic oligoethyleneimine (OEI)−β-cyclodextrin (βCD) clusters have been prepared, and their potential as gene delivery systems has been…”
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o‑Xylylene Protecting Group in Carbohydrate Chemistry: Application to the Regioselective Protection of a Single vic-Diol Segment in Cyclodextrins by Balbuena, Patricia, Gonçalves-Pereira, Rita, Jiménez Blanco, José L, García-Moreno, M. Isabel, Lesur, David, Ortiz Mellet, Carmen, García Fernández, José M

“…A systematic study of the suitability of α,α′-dibromo-o-xylene as a reagent for cyclic o-xylylene protection of vic-diols in different monosaccharide…”
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Targeted delivery of pharmacological chaperones for Gaucher disease to macrophages by a mannosylated cyclodextrin carrier by Rodríguez-Lavado, Julio, de la Mata, Mario, Jiménez-Blanco, José L, García-Moreno, M Isabel, Benito, Juan M, Díaz-Quintana, Antonio, Sánchez-Alcázar, José A, Higaki, Katsumi, Nanba, Eiji, Ohno, Kousaku, Suzuki, Yoshiyuki, Ortiz Mellet, Carmen, García Fernández, José M

“…Gaucher disease (GD) is a rare monogenetic disorder leading to dysfunction of acid β-glucosidase (β-glucocerebrosidase; GCase) and accumulation of…”
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Nanoparticle-Delivered HIV Peptides to Dendritic Cells a Promising Approach to Generate a Therapeutic Vaccine by Martín-Moreno, Alba, Jiménez Blanco, José L., Mosher, Jamie, Swanson, Douglas R., García Fernández, José M., Sharma, Ajit, Ceña, Valentín, Muñoz-Fernández, María Angeles

“…Finding a functional cure for HIV-1 infection will markedly decrease the social and economic burden of this disease. In this work, we have taken advantage of…”
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Urea-, Thiourea-, and Guanidine-Linked Glycooligomers as Phosphate Binders in Water by Jiménez Blanco, José L, Bootello, Purificación, Benito, Juan M, Ortiz Mellet, Carmen, García Fernández, José M

“…β-(1→6)-Linked pseudodi- and pseudotrisaccharides incorporating alternating pseudoamide-type (urea, thiourea, guanidine) intersaccharide bridges have been…”
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Comparative studies on lectin-carbohydrate interactions in low and high density homo- and heteroglycoclusters by Gómez-García, Marta, Benito, Juan M, Gutiérrez-Gallego, Ricardo, Maestre, Alfredo, Mellet, Carmen Ortiz, Fernández, José M García, Blanco, José L Jiménez

“…A versatile synthetic procedure to construct series of high- and low-density homo- and heteroglycoclusters is reported. The binding properties of these…”
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(Pseudo)amide-linked oligosaccharide mimetics: molecular recognition and supramolecular properties by Jiménez Blanco, José L, Ortega-Caballero, Fernando, Ortiz Mellet, Carmen, García Fernández, José M

“…Oligosaccharides are currently recognised as having functions that influence the entire spectrum of cell activities. However, a distinct disadvantage of…”
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Enhanced Gene Delivery Triggered by Dual pH/Redox Responsive Host‐Guest Dimerization of Cyclooligosaccharide Star Polycations by Carbajo‐Gordillo, Ana I., López‐Fernández, José, Benito, Juan M., Jiménez Blanco, José L., Santana‐Armas, María L., Marcelo, Gema, Di Giorgio, Christophe, Przybylski, Cédric, Ortiz Mellet, Carmen, Tros de Ilarduya, Conchita, Mendicuti, Francisco, García Fernández, José M.

“…A robust strategy is reported to build perfectly monodisperse star polycations combining a trehalose‐based cyclooligosaccharide (cyclotrehalan, CT) central…”
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Synthesis of α- and β-Glycosyl Isothiocyanates via Oxazoline Intermediates by Jiménez Blanco, José L, Sylla, Balla, Ortiz Mellet, Carmen, García Fernández, José M

“…A practical synthesis of acylated glycosyl isothiocyanates from sugar oxazolines, by reaction with thiophosgene, is reported. In the absence of any additive,…”
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Trifaceted Mickey Mouse Amphiphiles for Programmable Self‐Assembly, DNA Complexation and Organ‐Selective Gene Delivery by Carbajo‐Gordillo, Ana I., González‐Cuesta, Manuel, Jiménez Blanco, José L., Benito, Juan M., Santana‐Armas, María L., Carmona, Thais, Di Giorgio, Christophe, Przybylski, Cédric, Ortiz Mellet, Carmen, Tros de Ilarduya, Conchita, Mendicuti, Francisco, García Fernández, José M.

“…Instilling segregated cationic and lipophilic domains with an angular disposition in a trehalose‐based trifaceted macrocyclic scaffold allows engineering…”
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Enantiopure 2-Thioxotetrahydro-1,3-O,N-heterocycles from Carbohydrates. 3. Enantiopure C-4 Chiral Oxazine- and Oxazolidine-2-thiones from 3-Deoxy-3-isothiocyanato Sugars by Garcia Fernandez, Jose M, Ortiz Mellet, Carmen, Jimenez Blanco, Jose L, Fuentes, Jose

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Cyclotrehalins: Cyclooligosaccharide Receptors Featuring a Hydrophobic Cavity by Benito, Juan M., Jiménez Blanco, José L., Ortiz Mellet, C., García Fernández, José M.

“…The “dark side” of cyclodextrins can be observed in cyclotrehalins, a new family of cyclooligosaccharide receptors made from α,α′‐trehalose building blocks. A…”
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Carbohydrate-Based Receptors with Multiple Thiourea Binding Sites. Multipoint Hydrogen Bond Recognition of Dicarboxylates and Monosaccharides by Benito, Juan M, Gómez-García, Marta, Jiménez Blanco, José L, Ortiz Mellet, Carmen, García Fernández, José M

“…The binding properties of multitopic sugar thiourea receptors toward dicarboxylate and monosaccharide guests have been examined taking glutarate and octyl…”
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