Search Results - "Jimenez‐Vera, Elvira"
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Standardisation of flow cytometry for whole blood immunophenotyping of islet transplant and transplant clinical trial recipients
Published in PloS one (22-05-2019)“…Understanding the immunological phenotype of transplant recipients is important to improve outcomes and develop new therapies. Immunophenotyping of whole…”
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Low-Dose Interleukin-2 Combined With Rapamycin Led to an Expansion of CD4 + CD25 + FOXP3 + Regulatory T Cells and Prolonged Human Islet Allograft Survival in Humanized Mice
Published in Diabetes (New York, N.Y.) (01-08-2020)“…Islet transplantation is an emerging therapy for type 1 diabetes and hypoglycemic unawareness. However, a key challenge for islet transplantation is cellular…”
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Long-term cultured neonatal islet cell clusters demonstrate better outcomes for reversal of diabetes: in vivo and molecular profiles
Published in Xenotransplantation (Københaven) (01-03-2015)“…Background Porcine neonatal islet‐like cell clusters (NICC) are being considered as a source of β‐cell replacement. However, the lag time to full function due…”
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Insulin antibodies are prevalent in adults with type 1 diabetes referred for islet cell transplantation and are modified by islet transplantation and immunosuppression: an Australian experience
Published in Internal medicine journal (01-08-2022)“…We have analysed insulin antibodies in 149 adults with type 1 diabetes and 2859 people without diabetes. We have determined that insulin antibody levels are…”
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Epithelial-to-Mesenchymal Transition in Early Transplant Tubulointerstitial Damage
Published in Journal of the American Society of Nephrology (01-08-2008)“…It is unknown whether epithelial-to-mesenchymal transition (EMT) leads to tubulointerstitial fibrosis in renal transplants. In this study, interstitial…”
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414.12: Potent Suppressive Function of Xeno-Antigen Reactive Human HLADR+CD27+Tregs via Enhanced CD95 and ICOS Expressions
Published in Transplantation (01-09-2022)Get full text
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247.3: T cell receptors and the transcriptomic profile of t cells in transplant tolerance
Published in Transplantation (01-09-2024)Get full text
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51: The Westmead Islet Transplant Program Evaluation of Factors Influencing Islet Isolation Outcomes Over 20 Years
Published in Transplantation (01-09-2019)Get full text
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Decoding the hallmarks of allograft dysfunction with a comprehensive pan-organ transcriptomic atlas
Published in Nature medicine (18-06-2024)“…The pathogenesis of allograft (dys)function has been increasingly studied using 'omics'-based technologies, but the focus on individual organs has created…”
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414.9: Shared Transcriptional Trajectory of Tissue Tregs Between Tolerant-Grafts and Lymphoid Organs in Transplant Tolerance
Published in Transplantation (01-09-2022)Get full text
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Low Dose IL-2 and Rapamycin Leads to Prolongation of Human Islet Allograft Survival by Inhibition of IFN-gamma+ T cells and Expansion of FOXP3+CD25+ Tregs in a Humanized Islet Transplant Mouse Model
Published in Transplantation (01-07-2018)“…INTRODUCTIONWe established a humanised mouse model with dominant human (h) CD3 T cells engraftment and showed it was capable of rejecting h-islet allografts…”
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Correlation of Dynamic Immune Cell Profile with Individual Alloresponse and Outcome in Type 1 Diabetes Islet Transplantation Recipients
Published in Transplantation (01-07-2018)“…To evaluate dynamic whole blood immune profile(WBIP) of T1D islet transplant(Tx) recipient(R) pre &post-transplant(Tx), and evaluate for correlation with Tx…”
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Standardized Whole-Blood Immunophenotyping Panels on Flow Cytometry for Transplant Recipients and Clinical Trials
Published in Transplantation (01-07-2018)“…INTRODUCTIONImmunophenotyping of whole blood by flow cytometry is a reliable, fast, and easy method used to obtain a large amount of information on the effects…”
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Immune Phenotype by Flow Cytometry of Paediatric Kidney Transplant Recipients and Healthy Adult Controls
Published in Transplantation (01-07-2018)“…INTRODUCTIONThe proportion of immune cell subsets in paediatric kidney transplant recipients could help monitor the best approach to allow tolerance to renal…”
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Intragraft memory-like CD127hiCD4+Foxp3+ Tregs maintain transplant tolerance
Published in JCI insight (13-02-2024)“…CD4+Foxp3+ regulatory T cells (Tregs) play an essential role in suppressing transplant rejection, but their role within the graft and heterogeneity in…”
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Key driver genes as potential therapeutic targets in renal allograft rejection
Published in JCI insight (06-08-2020)“…Acute rejection (AR) in renal transplantation is an established risk factor for reduced allograft survival. Molecules with regulatory control among immune…”
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