Search Results - "Jimenez, Mark"

Neuroendocrine androgen action is a key extraovarian mediator in the development of polycystic ovary syndrome by Caldwell, Aimee S. L., Edwards, Melissa C., Desai, Reena, Jimenez, Mark, Gilchrist, Robert B., Handelsman, David J., Walters, Kirsty A.

“…Polycystic ovary syndrome (PCOS) is a complex hormonal disorder characterized by reproductive, endocrine, and metabolic abnormalities. As the origins of PCOS…”
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Measurement of Estradiol in Human Serum by LC-MS/MS Using a Novel Estrogen-Specific Derivatization Reagent by Keski-Rahkonen, Pekka, Desai, Reena, Jimenez, Mark, Harwood, D. Tim, Handelsman, David J

“…A liquid chromatography–tandem mass spectrometry (LC-MS/MS) method is described that employs a novel derivatization reagent for the measurement of serum…”
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In Vivo Actions of the Sertoli Cell Glucocorticoid Receptor by Hazra, Rasmani, Upton, Dannielle, Jimenez, Mark, Desai, Reena, Handelsman, David J, Allan, Charles M

“…We determined the functional role of the Sertoli cell glucocorticoid receptor (GR) in vivo using a transgenic Cre-loxP approach to conditionally disrupt GR…”
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Sertoli Cell Androgen Receptor Expression Regulates Temporal Fetal and Adult Leydig Cell Differentiation, Function, and Population Size by Hazra, Rasmani, Jimenez, Mark, Desai, Reena, Handelsman, David J, Allan, Charles M

“…We recently created a mouse model displaying precocious Sertoli cell (SC) and spermatogenic development induced by SC-specific transgenic androgen receptor…”
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Characterizing the neuroendocrine and ovarian defects of androgen receptor-knockout female mice by Cheng, Xiaobing B, Jimenez, Mark, Desai, Reena, Middleton, Linda J, Joseph, Shai R, Ning, Guang, Allan, Charles M, Smith, Jeremy T, Handelsman, David J, Walters, Kirsty A

“…Homozygous androgen receptor (AR)-knockout (ARKO) female mice are subfertile due to both intra- and extraovarian (neuroendocrine) defects as defined by ovary…”
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Continuous testosterone administration prevents skeletal muscle atrophy and enhances resistance to fatigue in orchidectomized male mice by Axell, Anna-Maree, MacLean, Helen E, Plant, David R, Harcourt, Leah J, Davis, Jennifer A, Jimenez, Mark, Handelsman, David J, Lynch, Gordon S, Zajac, Jeffrey D

“…Androgens promote anabolism in skeletal muscle; however, effects on subsequent muscle function are less well defined because of a lack of reliable experimental…”
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Osteoblast Deletion of Exon 3 of the Androgen Receptor Gene Results in Trabecular Bone Loss in Adult Male Mice by Notini, Amanda J, McManus, Julie F, Moore, Alison, Bouxsein, Mary, Jimenez, Mark, Chiu, WS Maria, Glatt, Vaida, Kream, Barbara E, Handelsman, David J, Morris, Howard A, Zajac, Jeffrey D, Davey, Rachel A

“…The mechanism of androgen action on bone was studied in male mice with the AR deleted in mature osteoblasts. These mice had decreased trabecular bone volume…”
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Disruption of Prostate Epithelial Androgen Receptor Impedes Prostate Lobe-Specific Growth and Function by Simanainen, Ulla, Allan, Charles M, Lim, Patrick, McPherson, Stephen, Jimenez, Mark, Zajac, Jeffrey D, Davey, Rachel A, Handelsman, David J

“…Prostate development and maturation requires stromal-epithelial interactions and androgen action via the androgen receptor (AR) within these compartments…”
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Complete Sertoli Cell Proliferation Induced by Follicle-Stimulating Hormone (FSH) Independently of Luteinizing Hormone Activity: Evidence from Genetic Models of Isolated FSH Action by Allan, Charles M, Garcia, Alvaro, Spaliviero, Jenny, Zhang, Fu-Ping, Jimenez, Mark, Huhtaniemi, Ilpo, Handelsman, David J

“…Defining the gonadal effects of FSH distinct from those of LH remains difficult. We have characterized and compared the level of Sertoli and germ cell…”
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Anterior prostate epithelial AR inactivation modifies estrogen receptor expression and increases estrogen sensitivity by Simanainen, Ulla, McNamara, Keely, Gao, Yan Ru, McPherson, Stephen, Desai, Reena, Jimenez, Mark, Handelsman, David J

“…Androgens influence prostate growth and development, so androgen withdrawal can control progression of prostate diseases. Although estrogen treatment was…”
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Evidence for increased tissue androgen sensitivity in neurturin knockout mice by Simanainen, Ulla, Gao, Yan Ru (Ellen), Desai, Reena, Jimenez, Mark, Spaliviero, Jennifer, Keast, Janet R, Handelsman, David J

“…Neurturin (NTN) is a member of the glial cell line-derived neurotrophic factor (GDNF) family and signals through GDNF family receptor alpha 2 (GFRα2). We…”
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Targeted Loss of Androgen Receptor Signaling in Murine Granulosa Cells of Preantral and Antral Follicles Causes Female Subfertility1 by Walters, Kirsty A, Middleton, Linda J, Joseph, Shai R, Hazra, Rasmani, Jimenez, Mark, Simanainen, Ulla, Allan, Charles M, Handelsman, David J

“…Ovarian granulosa cells display strong androgen receptor (AR) expression, suggesting a functional role for direct AR-mediated actions within developing…”
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Luteinizing Hormone Receptor-Mediated Effects on Initiation of Spermatogenesis in Gonadotropin-Deficient (hpg) Mice Are Replicated by Testosterone by SPALIVIERO, Jennifer A, JIMENEZ, Mark, ALLAN, Charles M, HANDELSMAN, David J

“…Testosterone (T) is an absolute requirement for spermatogenesis and is supplied by mature Leydig cells stimulated by LH. We previously showed in…”
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Maintenance of Spermatogenesis by the Activated Human (Asp567Gly) FSH Receptor During Testicular Regression Due to Hormonal Withdrawal by ALLAN, Charles M, GARCIA, Alvaro, SPALIVIERO, Jenny, JIMENEZ, Mark

“…The first activating mutation of the FSH receptor (FSHR*D567G) was identified in a gonadotropin-deficient hypophysectomized man who exhibited persistent…”
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Oestradiol-induced spermatogenesis requires a functional androgen receptor by Lim, Patrick, Allan, Charles M, Notini, Amanda J, Axell, Anna-Maree, Spaliviero, Jennifer, Jimenez, Mark, Davey, Rachel, McManus, Julie, MacLean, Helen E, Zajac, Jeffrey D, Handelsman, David J

“…Spermatogenesis requires androgen but, paradoxically, oestradiol (E2) treatment stimulates spermatogenic development in gonadotrophin- and androgen-deficient…”
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Detection confidence driven multi-object tracking to recover reliable tracks from unreliable detections by Mandel, Travis, Jimenez, Mark, Risley, Emily, Nammoto, Taishi, Williams, Rebekka, Panoff, Max, Ballesteros, Meynard, Suarez, Bobbie

“…•Existing multi-object tracking methods do not make full use of the detection confidence values.•Using the exact unfiltered detection confidence values…”
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Understanding PhD Latinx Career Outcomes: A Case Study by Kamimura-Jimenez, Mark, Gonzalez, John

“…This study explored the career outcomes for Latinx doctoral students and the contextual factors of their educational experience influencing these outcomes. A…”
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Luteinizing Hormone Receptor-Mediated Effects on Initiation of Spermatogenesis in Gonadotropin-Deficient (hpg) Mice Are Replicated by Testosterone1 by Spaliviero, Jennifer A, Jimenez, Mark, Allan, Charles M, Handelsman, David J

“…Testosterone (T) is an absolute requirement for spermatogenesis and is supplied by mature Leydig cells stimulated by LH. We previously showed in…”
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Performance of direct estradiol immunoassays with human male serum samples by Handelsman, David J, Newman, Julie D, Jimenez, Mark, McLachlan, Robert, Sartorius, Gideon, Jones, Graham R D

“…Steroid immunoassays originally required solvent extraction, chromatography, and structurally authentic tracers to avoid interference from steroid…”
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Adversarial Sampling-Based Motion Planning by Nichols, Hayden, Jimenez, Mark, Goddard, Zachary, Sparapany, Michael, Boots, Byron, Mazumdar, Anirban

“…There are many scenarios in which a mobile agent may not want its path to be predictable. Examples include preserving privacy or confusing an adversary…”
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