Search Results - "Jimenez, Heidy"

Tau passive immunotherapy in mutant P301L mice: antibody affinity versus specificity by d'Abramo, Cristina, Acker, Christopher M, Jimenez, Heidy T, Davies, Peter

“…The use of antibodies to treat neurodegenerative diseases has undergone rapid development in the past decade. To date, immunotherapeutic approaches to…”
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Small molecule inhibitor of tau self-association in a mouse model of tauopathy: A preventive study in P301L tau JNPL3 mice by Davidowitz, Eliot J, Lopez, Patricia, Jimenez, Heidy, Adrien, Leslie, Davies, Peter, Moe, James G

“…Advances in tau biology and the difficulties of amyloid-directed immunotherapeutics have heightened interest in tau as a target for small molecule drug…”
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Anesthesia promotes acute expression of genes related to Alzheimer’s disease and latent tau aggregation in transgenic mouse models of tauopathy by Eun, John David, Jimenez, Heidy, Adrien, Leslie, Wolin, Adam, Marambaud, Philippe, Davies, Peter, Koppel, Jeremy L.

“…BackgroundExposure to anesthesia in the elderly might increase the risk of dementia. Although the mechanism underlying the association is uncertain, anesthesia…”
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Passive Immunization in JNPL3 Transgenic Mice Using an Array of Phospho-Tau Specific Antibodies by d'Abramo, Cristina, Acker, Christopher M, Jimenez, Heidy, Davies, Peter

“…Recent work from our lab and few others have strongly suggested that immunotherapy could be an effective means of preventing the development of tau…”
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In Vivo Validation of a Small Molecule Inhibitor of Tau Self-Association in htau Mice by Davidowitz, Eliot J, Krishnamurthy, Pavan K, Lopez, Patricia, Jimenez, Heidy, Adrien, Leslie, Davies, Peter, Moe, James G

“…Tau oligomers have been shown to transmit tau pathology from diseased neurons to healthy neurons through seeding, tau misfolding, and aggregation that is…”
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The Impact of Muscarinic Antagonism on Psychosis-Relevant Behaviors and Striatal [11C] Raclopride Binding in Tau Mouse Models of Alzheimer’s Disease by Jimenez, Heidy, Carrion, Joseph, Adrien, Leslie, Wolin, Adam, Eun, John, Cinamon, Ezra, Chang, Eric H., Davies, Peter, Vo, An, Koppel, Jeremy

“…Psychosis that occurs over the course of Alzheimer’s disease (AD) is associated with increased caregiver burden and a more rapid cognitive and functional…”
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The impact of pimavanserin on psychotic phenotypes and tau phosphorylation in the P301L/COMT– and rTg(P301L)4510 mouse models of Alzheimer's disease by Jimenez, Heidy, Adrien, Leslie, Wolin, Adam, Eun, John, Chang, Eric H., Burstein, Ethan S., Gomar, Jesus, Davies, Peter, Koppel, Jeremy

“…Introduction Psychosis in Alzheimer's disease (AD) is associated with grave clinical consequences including a precipitous cognitive decline and a hastened…”
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CB₂ receptor deficiency increases amyloid pathology and alters tau processing in a transgenic mouse model of Alzheimer's disease by Koppel, Jeremy, Vingtdeux, Valerie, Marambaud, Philippe, d'Abramo, Cristina, Jimenez, Heidy, Stauber, Mark, Friedman, Rachel, Davies, Peter

“…The endocannabinoid CB₂ receptor system has been implicated in the neuropathology of Alzheimer's disease (AD). In order to investigate the impact of the CB₂…”
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Tau release from hTau mouse primary neuronal cultures by d'Abramo, Cristina, Jimenez, Heidy T, Acker, Christopher M, Davies, Peter

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In vivo validation of a lead compound targeting tau self‐association in two mouse models of tauopathy: Preclinical small molecule drug discovery by Moe, James G., Lopez, Patricia, Jimenez, Heidy, Adrien, Leslie, Davies, Peter, Davidowitz, Eliot J.

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In vivo validation of a lead compound targeting tau self‐association in two mouse models of tauopathy by Moe, James G., Lopez, Patricia, Jimenez, Heidy, Adrien, Leslie, Davies, Peter, Davidowitz, Eliot J.

“…Background Tau self‐association is the initial step in the formation of toxic tau oligomers and larger aggregates. Our program is highly differentiated in that…”
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CB2 receptor deficiency increases amyloid pathology and alters tau processing in a transgenic mouse model of Alzheimer's disease by Koppel, Jeremy, Vingtdeux, Valerie, Marambaud, Philippe, d'Abramo, Cristina, Jimenez, Heidy, Stauber, Mark, Friedman, Rachel, Davies, Peter

“…The endocannabinoid CB2 receptor system has been implicated in the neuropathology of Alzheimer's disease (AD). In order to investigate the impact of the CB2…”
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Increased tau phosphorylation follows impeded dopamine clearance in a P301L and novel P301L/COMT‐deleted (DM) tau mouse model by Koppel, Jeremy, Jimenez, Heidy, Adrien, Leslie, H. Chang, Eric, Malhotra, Anil K., Davies, Peter

“…In Alzheimer's disease, the phosphorylation of tau is a critical event preceding the formation of neurofibrillary tangles. Previous work exploring the impact…”
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In vivo validation of therapeutic efficacy of a small molecule lead targeting tau self‐association in JNPL3 mice by Moe, James G., Lopez, Patricia, Jimenez, Heidy, Adrien, Leslie, Eun, John D, Wolin, Adam, Koppel, Jeremy, Davies, Peter, Davidowitz, Eliot J.

“…Background Small molecules were screened and optimized for inhibiting tau self‐association, the initial step in the formation of soluble toxic tau oligomers…”
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LINEAR DOSE-DEPENDENT INHIBITION OF TAU AGGREGATION IN VIVO WITH SMALL MOLECULE by Moe, James G., Lopez, Patricia, Jimenez, Heidy, Adrien, Leslie, Davies, Peter, Davidowitz, Eliot J.

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P4‐698: LINEAR DOSE‐DEPENDENT INHIBITION OF TAU AGGREGATION IN VIVO WITH SMALL MOLECULE by Moe, James G., Lopez, Patricia, Jimenez, Heidy, Adrien, Leslie, Davies, Peter, Davidowitz, Eliot J.

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IN VIVO EFFICACY OF A SMALL MOLECULE INHIBITOR OF TAU OLIGOMER FORMATION IN HTAU MICE by Moe, James G., Lopez, Patricia, Jimenez, Heidy, Adrien, Leslie, Davies, Peter, Davidowitz, Eliot J.

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P4‐222: IN VIVO EFFICACY OF A SMALL MOLECULE INHIBITOR OF TAU OLIGOMER FORMATION IN HTAU MICE by Moe, James G., Lopez, Patricia, Jimenez, Heidy, Adrien, Leslie, Davies, Peter, Davidowitz, Eliot J.

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The Impact of Muscarinic Antagonism on Psychosis-Relevant Behaviors and Striatal [[sup.11]C] Raclopride Binding in Tau Mouse Models of Alzheimer’s Disease by Jimenez, Heidy, Carrion, Joseph, Adrien, Leslie, Wolin, Adam, Eun, John, Cinamon, Ezra, Chang, Eric H, Davies, Peter, Vo, An, Koppel, Jeremy

“…Psychosis that occurs over the course of Alzheimer’s disease (AD) is associated with increased caregiver burden and a more rapid cognitive and functional…”
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Psychotic Alzheimer's disease is associated with gender-specific tau phosphorylation abnormalities by Koppel, Jeremy, Acker, Chris, Davies, Peter, Lopez, Oscar L, Jimenez, Heidy, Azose, Miriam, Greenwald, Blaine S, Murray, Patrick S, Kirkwood, Caitlin M, Kofler, Julia, Sweet, Robert A

“…Abstract Converging evidence suggests that psychotic Alzheimer's disease (AD + P) is associated with an acceleration of frontal degeneration, with tau…”
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