Search Results - "Jiménez Agüero, Raul"
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Serum extracellular vesicles contain protein biomarkers for primary sclerosing cholangitis and cholangiocarcinoma
Published in Hepatology (Baltimore, Md.) (01-10-2017)“…Cholangiocarcinoma (CCA) includes a heterogeneous group of biliary cancers with poor prognosis. Several conditions, such as primary sclerosing cholangitis…”
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Non-parenchymal TREM-2 protects the liver from immune-mediated hepatocellular damage
Published in Gut (01-03-2019)“…Liver injury impacts hepatic inflammation in part via Toll-like receptor (TLR) signalling. Triggering receptor expressed on myeloid cells 2 (TREM-2) modulates…”
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TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms
Published in Gut (01-07-2021)“…Hepatocellular carcinoma (HCC) is a prevalent and aggressive cancer usually arising on a background of chronic liver injury involving inflammatory and hepatic…”
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RIPK3 acts as a lipid metabolism regulator contributing to inflammation and carcinogenesis in non-alcoholic fatty liver disease
Published in Gut (01-12-2021)“…Receptor-interacting protein kinase 3 (RIPK3) is a key player in necroptosis execution and an emerging metabolic regulator, whose contribution to non-alcoholic…”
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MicroRNA‐506 promotes primary biliary cholangitis–like features in cholangiocytes and immune activation
Published in Hepatology (Baltimore, Md.) (01-04-2018)“…Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease associated with autoimmune phenomena targeting intrahepatic bile duct cells…”
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miR-21-5p promotes NASH-related hepatocarcinogenesis
Published in Liver international (01-10-2023)“…The mechanisms governing the progression of non-alcoholic fatty liver disease (NAFLD) towards steatohepatitis (NASH) and hepatocellular carcinoma (HCC) remain…”
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PNPLA3 p.I148M variant is associated with greater reduction of liver fat content after bariatric surgery
Published in Surgery for obesity and related diseases (01-12-2016)“…Abstract Background Obesity is the major trigger of nonalcoholic fatty liver disease (NAFLD). NAFLD is further favored by the patatin-like phospholipase…”
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Proteostasis disturbances and endoplasmic reticulum stress contribute to polycystic liver disease: New therapeutic targets
Published in Liver international (01-07-2020)“…Background & Aims Polycystic liver diseases (PLDs) are genetic disorders characterized by progressive development of multiple biliary cysts. Recently, novel…”
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Ursodeoxycholic acid inhibits hepatic cystogenesis in experimental models of polycystic liver disease
Published in Journal of hepatology (01-10-2015)“…Background & Aims Polycystic liver diseases (PLDs) are genetic disorders characterized by progressive biliary cystogenesis. Current therapies show short-term…”
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Inhibition of metalloprotease hyperactivity in cystic cholangiocytes halts the development of polycystic liver diseases
Published in Gut (01-10-2014)“…Polycystic liver diseases (PCLDs) are genetic disorders characterised by progressive bile duct dilatation and/or cyst development. Their pathogenesis is a…”
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Adiponectin, Leptin, and IGF-1 are useful diagnostic and stratification biomarkers of NAFLD
Published in Frontiers in medicine (23-06-2021)“…Copyright © 2021 Marques, Afonso, Bierig, Duarte-Ramos, Santos-Laso, Jimenez-Agüero, Eizaguirre, Bujanda, Pareja, Luís, Costa, Machado, Alonso, Arretxe,…”
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The altered serum lipidome and its diagnostic potential for Non-Alcoholic Fatty Liver (NAFL)-associated hepatocellular carcinoma
Published in EBioMedicine (01-11-2021)“…Non-alcoholic fatty liver disease (NAFLD) is affecting more people globally. Indeed, NAFLD is a spectrum of metabolic dysfunctions that can progress to…”
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Subcuticular suture and incisional surgical-site infection in elective hepatobiliary and pancreatic surgery: an open-label, pragmatic randomized clinical trial (CLOSKIN trial)
Published in BMC surgery (13-01-2023)“…Subcuticular suture has proven to reduce superficial incisional SSI (si-SSI) in clean surgery. However, question remains regarding clean-contaminated…”
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Molecular Mechanisms of Cholangiocarcinogenesis: New Potential Targets for Therapy
Published in Current drug targets (01-01-2017)“…Cholangiocarcinoma (CCA) is a heterogeneous group of dysplastic disorders affecting the biliary epithelium. It is the second most common primary liver tumor…”
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Hepatic abscesses secondary to a foreign body in the common bile duct
Published in Revista española de enfermedades digestivas (01-09-2017)“…Hepatic abscesses subsequent to a gastrointestinal perforation after the ingestion of a foreign body are rare, even more so if the perforation passes through…”
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Paraganglioma gangliocítico metastásico: una rara entidad histológica diagnosticada tras una duodenopancreatectomía
Published in Revista colombiana de cirugía (08-05-2023)“…Introducción. El paraganglioma gangliocítico es una entidad histológica infrecuente, siendo el duodeno su principal localización extra ganglionar. Caso…”
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Liquid biopsy-based protein biomarkers for risk prediction, early diagnosis, and prognostication of cholangiocarcinoma
Published in Journal of hepatology (01-07-2023)“…Cholangiocarcinoma (CCA), heterogeneous biliary tumours with dismal prognosis, lacks accurate early diagnostic methods especially important for individuals at…”
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SOX17 regulates cholangiocyte differentiation and acts as a tumor suppressor in cholangiocarcinoma
Published in Journal of hepatology (01-07-2017)“…Graphical abstract…”
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Metabolomic‐based noninvasive serum test to diagnose nonalcoholic steatohepatitis: Results from discovery and validation cohorts
Published in Hepatology communications (01-07-2018)“…Nonalcoholic fatty liver disease (NAFLD) is the most common type of chronic liver disease worldwide and includes a broad spectrum of histologic phenotypes,…”
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