Search Results - "Jiménez, Connie"

The cancer secretome, current status and opportunities in the lung, breast and colorectal cancer context by Schaaij-Visser, Tieneke B.M., de Wit, Meike, Lam, Siu W., Jiménez, Connie R.

“…Despite major improvements on the knowledge and clinical management, cancer is still a deadly disease. Novel biomarkers for better cancer detection, diagnosis…”
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Inferring kinase activity from phosphoproteomic data: Tool comparison and recent applications by Piersma, Sander R., Valles‐Marti, Andrea, Rolfs, Frank, Pham, Thang V., Henneman, Alex A., Jiménez, Connie R.

“…Aberrant cellular signaling pathways are a hallmark of cancer and other diseases. One of the most important signaling mechanisms involves protein…”
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Workflow Comparison for Label-Free, Quantitative Secretome Proteomics for Cancer Biomarker Discovery: Method Evaluation, Differential Analysis, and Verification in Serum by Piersma, Sander R, Fiedler, Ulrike, Span, Simone, Lingnau, Andreas, Pham, Thang V, Hoffmann, Steffen, Kubbutat, Michael H. G, Jiménez, Connie R

“…The cancer cell secretome has emerged as an attractive subproteome for discovery of candidate blood-based biomarkers. To choose the best performing workflow,…”
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Loss of VRK1 alters the nuclear phosphoproteome in the DNA damage response to doxorubicin by Navarro-Carrasco, Elena, Campos-Díaz, Aurora, Monte-Serrano, Eva, Rolfs, Frank, de Goeij-de Haas, Richard, Pham, Thang V., Piersma, Sander R., Jiménez, Connie R., Lazo, Pedro A.

“…Dynamic chromatin remodeling requires regulatory mechanisms for its adaptation to different nuclear function, which are likely to be mediated by signaling…”
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The translatome of glioblastoma by Cornelissen, Fleur M G, He, Zhaoren, Ciputra, Edward, de Haas, Richard R, Beumer-Chuwonpad, Ammarina, Noske, David, Vandertop, W Peter, Piersma, Sander R, Jiménez, Connie R, Murre, Cornelis, Westerman, Bart A

“…Glioblastoma (GB), the most common and aggressive brain tumor, demonstrates intrinsic resistance to current therapies, resulting in poor clinical outcomes…”
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Mycosins Are Required for the Stabilization of the ESX-1 and ESX-5 Type VII Secretion Membrane Complexes by van Winden, Vincent J C, Ummels, Roy, Piersma, Sander R, Jiménez, Connie R, Korotkov, Konstantin V, Bitter, Wilbert, Houben, Edith N G

“…Pathogenic mycobacteria contain up to five type VII secretion (T7S) systems, ESX-1 to ESX-5. One of the conserved T7S components is the serine protease mycosin…”
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PPE and PE_PGRS proteins of Mycobacterium marinum are transported via the type VII secretion system ESX‐5 by Abdallah, Abdallah M., Verboom, Theo, Weerdenburg, Eveline M., Gey van Pittius, Nicolaas C., Mahasha, Phetole W., Jiménez, Connie, Parra, Marcela, Cadieux, Nathalie, Brennan, Michael J., Appelmelk, Ben J., Bitter, Wilbert

“…Summary ESX‐5 is one of the five type VII secretion systems found in mycobacteria. These secretion systems are also known as ESAT‐6‐like secretion systems…”
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Whole gel processing procedure for GeLC-MS/MS based proteomics by Piersma, Sander R, Warmoes, Marc O, de Wit, Meike, de Reus, Inge, Knol, Jaco C, Jiménez, Connie R

“…SDS-PAGE followed by in-gel digestion (IGD) is a popular workflow in mass spectrometry-based proteomics. In GeLC-MS/MS, a protein lysate of a biological sample…”
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Specific Chaperones for the Type VII Protein Secretion Pathway by Daleke, Maria H., van der Woude, Aniek D., Parret, Annabel H.A., Ummels, Roy, de Groot, A.Marit, Watson, David, Piersma, Sander R., Jiménez, Connie R., Luirink, Joen, Bitter, Wilbert, Houben, Edith N.G.

“…Mycobacteria use the dedicated type VII protein secretion systems ESX-1 and ESX-5 to secrete virulence factors across their highly hydrophobic cell envelope…”
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EspH is a hypervirulence factor for Mycobacterium marinum and essential for the secretion of the ESX-1 substrates EspE and EspF by Phan, Trang H, van Leeuwen, Lisanne M, Kuijl, Coen, Ummels, Roy, van Stempvoort, Gunny, Rubio-Canalejas, Alba, Piersma, Sander R, Jiménez, Connie R, van der Sar, Astrid M, Houben, Edith N G, Bitter, Wilbert

“…The pathogen Mycobacterium tuberculosis employs a range of ESX-1 substrates to manipulate the host and build a successful infection. Although the importance of…”
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Genome-wide siRNA Screen Identifies the Radiosensitizing Effect of Downregulation of MASTL and FOXM1 in NSCLC by Nagel, Remco, Stigter-van Walsum, Marijke, Buijze, Marijke, van den Berg, Jaap, van der Meulen, Ida H, Hodzic, Jasmina, Piersma, Sander R, Pham, Thang V, Jiménez, Connie R, van Beusechem, Victor W, Brakenhoff, Ruud H

“…Lung cancer is the most common cancer worldwide and on top of that has a very poor prognosis, which is reflected by a 5-year survival rate of 5% to 15%…”
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Proteomics of the TRAP-induced platelet releasate by Piersma, Sander R., Broxterman, Henk J., Kapci, Muhammed, de Haas, Richard R., Hoekman, Klaas, Verheul, Henk M.W., Jiménez, Connie R.

“…Upon stimulation, platelets release the soluble content of their cytoplasmic granules along with microparticles. This sub-proteome is of interest since many of…”
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Colorectal cancer derived organotypic spheroids maintain essential tissue characteristics but adapt their metabolism in culture by Rajcevic, Uros, Knol, Jaco C, Piersma, Sander, Bougnaud, Sébastien, Fack, Fred, Sundlisaeter, Eirik, Søndenaa, Karl, Myklebust, Reidar, Pham, Thang V, Niclou, Simone P, Jiménez, Connie R

“…Organotypic tumor spheroids, a 3D in vitro model derived from patient tumor material, preserve tissue heterogeneity and retain structural tissue elements, thus…”
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Essential Role of the ESX-5 Secretion System in Outer Membrane Permeability of Pathogenic Mycobacteria by Ates, Louis S, Ummels, Roy, Commandeur, Susanna, van de Weerd, Robert, van der Weerd, Robert, Sparrius, Marion, Weerdenburg, Eveline, Alber, Marina, Kalscheuer, Rainer, Piersma, Sander R, Abdallah, Abdallah M, Abd El Ghany, Moataz, Abdel-Haleem, Alyaa M, Pain, Arnab, Jiménez, Connie R, Bitter, Wilbert, Houben, Edith N G

“…Mycobacteria possess different type VII secretion (T7S) systems to secrete proteins across their unusual cell envelope. One of these systems, ESX-5, is only…”
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Peptide-mediated ‘miniprep’ isolation of extracellular vesicles is suitable for high-throughput proteomics by Knol, Jaco C., de Reus, Inge, Schelfhorst, Tim, Beekhof, Robin, de Wit, Meike, Piersma, Sander R., Pham, Thang V., Smit, Egbert F., Verheul, Henk M.W., Jiménez, Connie R.

“…[Display omitted] •A recent method to isolate extracellular vesicles was tested with proteomics.•Reproducibly delivers EV proteomes from small…”
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Proteomic analysis of cerebrospinal fluid extracellular vesicles: A comprehensive dataset by Chiasserini, Davide, van Weering, Jan R.T., Piersma, Sander R., Pham, Thang V., Malekzadeh, Arjan, Teunissen, Charlotte E., de Wit, Heidi, Jiménez, Connie R.

“…Extracellular vesicles (EVs) are present in human cerebrospinal fluid (CSF), yet little is known about their protein composition. The aim of this study is to…”
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Sorting and zooming: Subcellular proteomics is booming by Jiménez, Connie R.

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High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer by Böttger, Franziska, Vallés-Martí, Andrea, Cahn, Loraine, Jimenez, Connie R

“…Mounting evidence indicates that vitamin C has the potential to be a potent anti-cancer agent when administered intravenously and in high doses (high-dose…”
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Direct visualization by cryo-EM of the mycobacterial capsular layer: a labile structure containing ESX-1-secreted proteins by Sani, Musa, Houben, Edith N G, Geurtsen, Jeroen, Pierson, Jason, de Punder, Karin, van Zon, Maaike, Wever, Brigitte, Piersma, Sander R, Jiménez, Connie R, Daffé, Mamadou, Appelmelk, Ben J, Bitter, Wilbert, van der Wel, Nicole, Peters, Peter J

“…The cell envelope of mycobacteria, a group of Gram positive bacteria, is composed of a plasma membrane and a Gram-negative-like outer membrane containing…”
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Current status of cancer proteomics, how far are we from clinical applications? by Jiménez, Connie R, Slijper, Monique

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