Search Results - "Jiggins, Francis M"
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The spread of Wolbachia through mosquito populations
Published in PLoS biology (01-06-2017)“…In many regions of the world, mosquito-borne viruses pose a growing threat to human health. As an alternative to traditional control measures, the bacterial…”
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Symbionts commonly provide broad spectrum resistance to viruses in insects: a comparative analysis of Wolbachia strains
Published in PLoS pathogens (01-09-2014)“…In the last decade, bacterial symbionts have been shown to play an important role in protecting hosts against pathogens. Wolbachia, a widespread symbiont in…”
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Wolbachia protects Drosophila melanogaster against two naturally occurring and virulent viral pathogens
Published in Scientific reports (25-05-2023)“…Wolbachia is a common endosymbiont that can protect insects against viral pathogens. However, whether the antiviral effects of Wolbachia have a significant…”
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Wolbachia variants induce differential protection to viruses in Drosophila melanogaster: a phenotypic and phylogenomic analysis
Published in PLoS genetics (01-12-2013)“…Wolbachia are intracellular bacterial symbionts that are able to protect various insect hosts from viral infections. This tripartite interaction was initially…”
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Adaptive introgression underlies polymorphic seasonal camouflage in snowshoe hares
Published in Science (American Association for the Advancement of Science) (22-06-2018)“…Snowshoe hares ( ) maintain seasonal camouflage by molting to a white winter coat, but some hares remain brown during the winter in regions with low snow…”
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The intracellular bacterium Wolbachia uses parasitoid wasps as phoretic vectors for efficient horizontal transmission
Published in PLoS pathogens (01-02-2015)“…Facultative bacterial endosymbionts are associated with many arthropods and are primarily transmitted vertically from mother to offspring. However,…”
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The evolution and genetics of virus host shifts
Published in PLoS pathogens (01-11-2014)“…Emerging viral diseases are often the product of a host shift, where a pathogen jumps from its original host into a novel species. Phylogenetic studies show…”
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Trans-regulatory changes underpin the evolution of the Drosophila immune response
Published in PLoS genetics (07-11-2022)“…When an animal is infected, the expression of a large suite of genes is changed, resulting in an immune response that can defend the host. Despite much…”
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Widespread conservation and lineage-specific diversification of genome-wide DNA methylation patterns across arthropods
Published in PLoS genetics (25-06-2020)“…Cytosine methylation is an ancient epigenetic modification yet its function and extent within genomes is highly variable across eukaryotes. In mammals,…”
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Genome-wide association studies reveal a simple genetic basis of resistance to naturally coevolving viruses in Drosophila melanogaster
Published in PLoS genetics (01-11-2012)“…Variation in susceptibility to infectious disease often has a substantial genetic component in animal and plant populations. We have used genome-wide…”
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Population genomics of the Wolbachia endosymbiont in Drosophila melanogaster
Published in PLoS genetics (01-12-2012)“…Wolbachia are maternally inherited symbiotic bacteria, commonly found in arthropods, which are able to manipulate the reproduction of their host in order to…”
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Vertically transmitted viral endosymbionts of insects: do sigma viruses walk alone?
Published in Proceedings of the Royal Society. B, Biological sciences (07-10-2012)“…Insects are host to a wide range of vertically transmitted bacterial endosymbionts, but we know relatively little about their viral counterparts. Here, we…”
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Successive increases in the resistance of Drosophila to viral infection through a transposon insertion followed by a Duplication
Published in PLoS genetics (01-10-2011)“…To understand the molecular basis of how hosts evolve resistance to their parasites, we have investigated the genes that cause variation in the susceptibility…”
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The evolution of RNAi as a defence against viruses and transposable elements
Published in Philosophical transactions of the Royal Society of London. Series B. Biological sciences (12-01-2009)“…RNA interference (RNAi) is an important defence against viruses and transposable elements (TEs). RNAi not only protects against viruses by degrading viral RNA,…”
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Problems with mitochondrial DNA as a marker in population, phylogeographic and phylogenetic studies: the effects of inherited symbionts
Published in Proceedings of the Royal Society. B, Biological sciences (07-08-2005)“…Mitochondrial DNA (mtDNA) has been a marker of choice for reconstructing historical patterns of population demography, admixture, biogeography and speciation…”
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The phage gene wmk is a candidate for male killing by a bacterial endosymbiont
Published in PLoS pathogens (10-09-2019)“…Wolbachia are the most widespread maternally-transmitted bacteria in the animal kingdom. Their global spread in arthropods and varied impacts on animal…”
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Should Symbionts Be Nice or Selfish? Antiviral Effects of Wolbachia Are Costly but Reproductive Parasitism Is Not
Published in PLoS pathogens (01-07-2015)“…Symbionts can have mutualistic effects that increase their host's fitness and/or parasitic effects that reduce it. Which of these strategies evolves depends in…”
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The genetic architecture of resistance to virus infection in Drosophila
Published in Molecular ecology (01-10-2016)“…Variation in susceptibility to infection has a substantial genetic component in natural populations, and it has been argued that selection by pathogens may…”
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The causes and consequences of changes in virulence following pathogen host shifts
Published in PLoS pathogens (01-03-2015)“…Emerging infectious diseases are often the result of a host shift, where the pathogen originates from a different host species. Virulence--the harm a pathogen…”
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The evolution of constitutively active humoral immune defenses in Drosophila populations under high parasite pressure
Published in PLoS pathogens (01-01-2024)“…Both constitutive and inducible immune mechanisms are employed by hosts for defense against infection. Constitutive immunity allows for a faster response, but…”
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