Search Results - "Jiao, Kangwei"

Inhibition of the MAPK/c-Jun-EGR1 Pathway Decreases Photoreceptor Cell Death in the rd1 Mouse Model for Inherited Retinal Degeneration by Dong, Yujie, Xu, Wenrong, Li, Yan, Wei, Chunling, Hu, Yunzhang, Hu, Zhulin, Paquet-Durand, François, Jiao, Kangwei

“…Retinitis pigmentosa (RP) is a group of inherited retinal dystrophies that typically results in photoreceptor cell death and vision loss. Here, we explored the…”
Get full text

Single-Cell Transcriptomic Profiling in Inherited Retinal Degeneration Reveals Distinct Metabolic Pathways in Rod and Cone Photoreceptors by Chen, Yiyi, Dong, Yujie, Yan, Jie, Wang, Lan, Yu, Shirley, Jiao, Kangwei, Paquet-Durand, François

“…The cellular mechanisms underlying hereditary photoreceptor degeneration are still poorly understood. The aim of this study was to systematically map the…”
Get full text

T-type voltage-gated channels, Na+/Ca2+-exchanger, and calpain-2 promote photoreceptor cell death in inherited retinal degeneration by Yan, Jie, Wang, Lan, Yang, Qian-Lu, Yang, Qian-Xi, He, Xinyi, Dong, Yujie, Hu, Zhulin, Seeliger, Mathias W., Jiao, Kangwei, Paquet-Durand, François

“…Inherited retinal degenerations (IRDs) are a group of untreatable and commonly blinding diseases characterized by progressive photoreceptor loss. IRD pathology…”
Get full text

RNA Biological Characteristics at the Peak of Cell Death in Different Hereditary Retinal Degeneration Mutants by Wei, Chunling, Li, Yan, Feng, Xiaoxiao, Hu, Zhulin, Paquet-Durand, François, Jiao, Kangwei

“…Purpose: The present work investigated changes in the gene expression, molecular mechanisms, and pathogenesis of inherited retinal degeneration (RD) in three…”
Get full text

Inherited Retinal Degeneration: Towards the Development of a Combination Therapy Targeting Histone Deacetylase, Poly (ADP-Ribose) Polymerase, and Calpain by Dong, Yujie, Yan, Jie, Yang, Ming, Xu, Wenrong, Hu, Zhulin, Paquet-Durand, François, Jiao, Kangwei

“…Inherited retinal degeneration (IRD) represents a diverse group of gene mutation-induced blinding diseases. In IRD, the loss of photoreceptors is often…”
Get full text

Inherited Retinal Degeneration: PARP-Dependent Activation of Calpain Requires CNG Channel Activity by Yan, Jie, Günter, Alexander, Das, Soumyaparna, Mühlfriedel, Regine, Michalakis, Stylianos, Jiao, Kangwei, Seeliger, Mathias W, Paquet-Durand, François

“…Inherited retinal degenerations (IRDs) are a group of blinding diseases, typically involving a progressive loss of photoreceptors. The IRD pathology is often…”
Get full text

Tracking astrocyte polarization in the retina in retinopathy of prematurity by Feng, Xiaoxiao, Zhang, Liwei, Jiao, Kangwei, Li, Yunqing, Wu, Min, Xie, Yu, Xiao, Libo

“…Astrocyte patterns affect the normal development of the retinal vascular network in retinopathy of prematurity (ROP), which is associated with VEGF secretion…”
Get full text

miR-200-3p suppresses cell proliferation and reduces apoptosis in diabetic retinopathy via blocking the TGF-β2/Smad pathway by Xue, Liping, Xiong, Cheng, Li, Juanjuan, Ren, Yuling, Zhang, Liwei, Jiao, Kangwei, Chen, Chen, Ding, Peng

“…Increasing evidence has shown that microRNAs (miRNAs) play an important role in the pathogenesis of diabetic retinopathy (DR). However, the role and mechanism…”
Get full text

HDAC inhibition delays photoreceptor loss in Pde6b mutant mice of retinitis pigmentosa: insights from scRNA-seq and CUT&Tag by Dong, Yujie, Yan, Jie, Xu, Wenrong, Paquet-Durand, François, Hu, Zhulin, Jiao, Kangwei

“…This research aimed to ascertain the neuroprotective effect of histone deacetylase (HDAC) inhibition on retinal photoreceptors in mice, a model of retinitis…”
Get full text

Expression of glucose transporter‐2 in murine retina: Evidence for glucose transport from horizontal cells to photoreceptor synapses by Yang, Ming, Chen, Yiyi, Vagionitis, Stavros, Körtvely, Elöd, Ueffing, Marius, Schmachtenberg, Oliver, Hu, Zhulin, Jiao, Kangwei, Paquet‐Durand, François

“…The retina has the highest relative energy consumption of any tissue, depending on a steady supply of glucose from the bloodstream. Glucose uptake is mediated…”
Get full text

Integrative RNA-seq and ATAC-seq analyses of phosphodiesterase 6 mutation-induced retinitis pigmentosa by Xu, Wenrong, Li, Yan, Dong, Yujie, Xiao, Libo, Li, Lan, Jiao, Kangwei

“…Purpose Inhibition of poly-ADP-ribose polymerase 1 (PARP1) could relieve phosphodiesterase 6 mutation-induced retinitis pigmentosa (RP). However, the mechanism…”
Get full text

HDAC inhibition delays photoreceptor loss in Pde6b mutant mice of retinitis pigmentosa: insights from scRNA-seq and CUT Tag by Yujie Dong, Jie Yan, Wenrong Xu, François Paquet-Durand, Zhulin Hu, Kangwei Jiao

“…Purpose This research aimed to ascertain the neuroprotective effect of histone deacetylase (HDAC) inhibition on retinal photoreceptors in Pde6brd1 mice, a…”
Get full text

Retinitis pigmentosa: impact of different Pde6a point mutations on the disease phenotype by Sothilingam, Vithiyanjali, Garcia Garrido, Marina, Jiao, Kangwei, Buena-Atienza, Elena, Sahaboglu, Ayse, Trifunović, Dragana, Balendran, Sukirthini, Koepfli, Tanja, Mühlfriedel, Regine, Schön, Christian, Biel, Martin, Heckmann, Angelique, Beck, Susanne C, Michalakis, Stylianos, Wissinger, Bernd, Seeliger, Mathias W, Paquet-Durand, François

“…Mutations in the PDE6A gene can cause rod photoreceptors degeneration and the blinding disease retinitis pigmentosa (RP). While a number of pathogenic PDE6A…”
Get full text

T-type voltage-gated channels, Na + /Ca 2+ -exchanger, and calpain-2 promote photoreceptor cell death in inherited retinal degeneration by Yan, Jie, Wang, Lan, Yang, Qian-Lu, Yang, Qian-Xi, He, Xinyi, Dong, Yujie, Hu, Zhulin, Seeliger, Mathias W, Jiao, Kangwei, Paquet-Durand, François

“…Inherited retinal degenerations (IRDs) are a group of untreatable and commonly blinding diseases characterized by progressive photoreceptor loss. IRD pathology…”
Get full text