Search Results - "Jiangchun Xu"

Discovery of CC-90011: A Potent and Selective Reversible Inhibitor of Lysine Specific Demethylase 1 (LSD1) by Kanouni, Toufike, Severin, Christophe, Cho, Robert W, Yuen, Natalie Y.-Y, Xu, Jiangchun, Shi, Lihong, Lai, Chon, Del Rosario, Joselyn R, Stansfield, Ryan K, Lawton, Lee N, Hosfield, David, O’Connell, Shawn, Kreilein, Matt M, Tavares-Greco, Paula, Nie, Zhe, Kaldor, Stephen W, Veal, James M, Stafford, Jeffrey A, Chen, Young K

“…Histone demethylase LSDl (KDMlA) belongs to the flavin adenine dinucleotide (FAD) dependent family of monoamine oxidases and is vital in regulation of…”
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Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer by Wang, Kai, Kan, Junsuo, Yuen, Siu Tsan, Shi, Stephanie T, Chu, Kent Man, Law, Simon, Chan, Tsun Leung, Kan, Zhengyan, Chan, Annie S Y, Tsui, Wai Yin, Lee, Siu Po, Ho, Siu Lun, Chan, Anthony K W, Cheng, Grace H W, Roberts, Peter C, Rejto, Paul A, Gibson, Neil W, Pocalyko, David J, Mao, Mao, Xu, Jiangchun, Leung, Suet Yi

“…Suet Leung, Jiangchun Xu and colleagues report exome sequencing of 22 gastric cancers. They found that genes involved in chromatin modification were commonly…”
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Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma by Sung, Wing-Kin, Zheng, Hancheng, Li, Shuyu, Chen, Ronghua, Liu, Xiao, Li, Yingrui, Lee, Nikki P, Lee, Wah H, Ariyaratne, Pramila N, Tennakoon, Chandana, Mulawadi, Fabianus H, Wong, Kwong F, Liu, Angela M, Poon, Ronnie T, Fan, Sheung Tat, Chan, Kwong L, Gong, Zhuolin, Hu, Yujie, Lin, Zhao, Wang, Guan, Zhang, Qinghui, Barber, Thomas D, Chou, Wen-Chi, Aggarwal, Amit, Hao, Ke, Zhou, Wei, Zhang, Chunsheng, Hardwick, James, Buser, Carolyn, Xu, Jiangchun, Kan, Zhengyan, Dai, Hongyue, Mao, Mao, Reinhard, Christoph, Wang, Jun, Luk, John M

“…John Luk and colleagues report the sequencing of 81 hepatitis B virus (HBV)-positive and 7 HBV-negative hepatocellular carcinomas and matched normal tissues…”
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KDM4 Inhibition Targets Breast Cancer Stem-like Cells by Metzger, Eric, Stepputtis, Stella S, Strietz, Juliane, Preca, Bogdan-Tiberius, Urban, Sylvia, Willmann, Dominica, Allen, Anita, Zenk, Fides, Iovino, Nicola, Bronsert, Peter, Proske, Amelie, Follo, Marie, Boerries, Melanie, Stickeler, Elmar, Xu, Jiangchun, Wallace, Michael B, Stafford, Jeffrey A, Kanouni, Toufike, Maurer, Jochen, Schüle, Roland

“…Traditional treatments for breast cancer fail to address therapy-resistant cancer stem-like cells that have been characterized by changes in epigenetic…”
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Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma by Kan, Zhengyan, Zheng, Hancheng, Liu, Xiao, Li, Shuyu, Barber, Thomas D, Gong, Zhuolin, Gao, Huan, Hao, Ke, Willard, Melinda D, Xu, Jiangchun, Hauptschein, Robert, Rejto, Paul A, Fernandez, Julio, Wang, Guan, Zhang, Qinghui, Wang, Bo, Chen, Ronghua, Wang, Jian, Lee, Nikki P, Zhou, Wei, Lin, Zhao, Peng, Zhiyu, Yi, Kang, Chen, Shengpei, Li, Lin, Fan, Xiaomei, Yang, Jie, Ye, Rui, Ju, Jia, Wang, Kai, Estrella, Heather, Deng, Shibing, Wei, Ping, Qiu, Ming, Wulur, Isabella H, Liu, Jiangang, Ehsani, Mariam E, Zhang, Chunsheng, Loboda, Andrey, Sung, Wing Kin, Aggarwal, Amit, Poon, Ronnie T, Fan, Sheung Tat, Wang, Jun, Hardwick, James, Reinhard, Christoph, Dai, Hongyue, Li, Yingrui, Luk, John M, Mao, Mao

“…Hepatocellular carcinoma (HCC) is one of the most deadly cancers worldwide and has no effective treatment, yet the molecular basis of hepatocarcinogenesis…”
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Genomic landscape of copy number aberrations enables the identification of oncogenic drivers in hepatocellular carcinoma by Wang, Kai, Lim, Ho Yeong, Shi, Stephanie, Lee, Jeeyun, Deng, Shibing, Xie, Tao, Zhu, Zhou, Wang, Yuli, Pocalyko, David, Yang, Wei Jennifer, Rejto, Paul A., Mao, Mao, Park, Cheol‐Keun, Xu, Jiangchun

“…Cancer is a genetic disease with frequent somatic DNA alterations. Studying recurrent copy number aberrations (CNAs) in human cancers would enable the…”
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847 Optimal dose selection of ADG126 (a masked anti-CTLA-4 SAFEbody®) with significantly widened therapeutic index compared to ipilimumab in combination with anti-PD-1 antibodies informed by QSP modeling by Zheng, Songmao, Sun, Meng, Wang, Xin, Skinner, John J, Liu, Guizhong, She, Kristine, Xu, Jiangchun, Du, Felix, Li, Yan, Zha, Jiping, Luo, Peter

“…BackgroundFor the past 20 years, dose-dependent efficacy and toxicity of anti-CTLA-4 therapies have severely limited dosing and therapeutic index (TI)…”
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Liverome: a curated database of liver cancer-related gene signatures with self-contained context information by Lee, Langho, Wang, Kai, Li, Gang, Xie, Zhi, Wang, Yuli, Xu, Jiangchun, Sun, Shaoxian, Pocalyko, David, Bhak, Jong, Kim, Chulhong, Lee, Kee-Ho, Jang, Ye Jin, Yeom, Young Il, Yoo, Hyang-Sook, Hwang, Seungwoo

“…Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. A number of molecular profiling studies have investigated the changes in gene and…”
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P504S : A new molecular marker for the detection of prostate carcinoma by ZHONG JIANG, WODA, Bruce A, REED, Steven G, JIANGCHUN XU, FANGER, Gary R, ROCK, Kenneth L, YINGDAN XU, SAVAS, Lou, KHAN, Ashraf, PIHAN, German, FENG CAI, BABCOOK, John S, RATHANASWAMI, Palaniswami

“…The ability to diagnose prostate carcinoma would be improved by the detection of a tumor-associated antigen. P504S, a cytoplasmic protein, was recently…”
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Expression of α-methylacyl-coa racemase (p504s) in various malignant neoplasms and normal tissues: a study of 761 cases by Jiang, Zhong, Fanger, Gary R, Woda, Bruce A, Banner, Barbara F, Algate, Paul, Dresser, Karen, Xu, Jiangchun, Chu, Peiguo G

“…α-methylacyl CoA racemase (AMACR), also known as P504S, plays an important role in peroxisomal beta-oxidation of branched-chain fatty acids. It has recently…”
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P504S/α-methylacyl-CoA racemase: A useful marker for diagnosis of small foci of prostatic carcinoma on needle biopsy by ZHONG JIANG, WU, Chin-Lee, WODA, Bruce A, DRESSER, Karen, JIANGCHUN XU, FANGER, Gary R, YANG, Ximing J

“…Establishing a definitive diagnosis of malignancy in prostate needle biopsies with very small foci of adenocarcinoma is a major diagnostic challenge for…”
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Identification of differentially expressed genes in human prostate cancer using subtraction and microarray by JIANGCHUN XU, STOLK, J. A, XINQUN ZHANG, SILVA, S. J, HOUGHTON, R. L, MATSUMURA, M, VEDVICK, T. S, LESLIE, K. B, BADARO, R, REED, S. G

“…We have identified human prostate cancer- and tissue-specific genes using cDNA library subtraction in conjunction with high throughput microarray screening…”
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Discovery of differentially expressed genes in human breast cancer using subtracted cDNA libraries and cDNA microarrays by YUQIU JIANG, HARLOCKER, Susan L, MOLESH, David A, DILLON, David C, STOLK, John A, HOUGHTON, Raymond L, REPASKY, Elizabeth A, BADARO, Roberto, REED, Steven G, JIANGCHUN XU

“…Identifying novel and known genes that are differentially expressed in breast cancer has important implications in understanding the biology of breast…”
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Identification of Genes Overexpressed in Head and Neck Squamous Cell Carcinoma Using a Combination of Complementary DNA Subtraction and Microarray Analysis by Villaret, Douglas B., Wang, Tongtong, Dillon, Davin, Xu, Jiangchun, Sivam, Dhileep, Cheever, Martin A., Reed, Steven G.

“…Objectives/Hypothesis To discover unique genes specific for squamous cell carcinoma of the head and neck for eventual development as tumor markers and vaccine…”
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Identification and characterization of prostein, a novel prostate-specific protein by JIANGCHUN XU, KALOS, Michael, STOLK, John A, ZASLOFF, Eden J, XINQUN ZHANG, HOUGHTON, Raymond L, MALTEZ, Aristides FILHO, NOLASCO, Marcos, BADARO, Roberto, REED, Steven G

“…In this report, we describe the application of a systematic, genome-based approach to identify prostein, a novel prostate-specific protein expressed in normal…”
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Application of a Multigene Reverse Transcription-PCR Assay for Detection of Mammaglobin and Complementary Transcribed Genes in Breast Cancer Lymph Nodes by Zehentner, Barbara K, Dillon, Davin C, Jiang, Yuqiu, Xu, Jiangchun, Bennington, Angela, Molesh, David A, Zhang, XinQun, Reed, Steven G, Persing, David, Houghton, Raymond L

“…Mammaglobin mRNA expression is found in 70-80% of primary and metastatic breast tumor biopsies. The potential breast tumor markers B305D, B726P, and…”
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Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer by Wang, Kai, Yuen, Siu Tsan, Xu, Jiangchun, Lee, Siu Po, Yan, Helen H N, Shi, Stephanie T, Siu, Hoi Cheong, Deng, Shibing, Chu, Kent Man, Law, Simon, Chan, Kok Hoe, Chan, Annie S Y, Tsui, Wai Yin, Ho, Siu Lun, Chan, Anthony K W, Man, Jonathan L K, Foglizzo, Valentina, Ng, Man Kin, Chan, April S, Ching, Yick Pang, Cheng, Grace H W, Xie, Tao, Fernandez, Julio, Li, Vivian S W, Clevers, Hans, Rejto, Paul A, Mao, Mao, Leung, Suet Yi

“…Suet Yi Leung, Mao Mao and colleagues report whole-genome sequencing of 100 gastric cancers and DNA copy number, gene expression and methylation profiling of…”
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ADG153, an Anti-CD47 Monoclonal Antibody Prodrug, Has Strong In Vivo Anti-Tumor Activity, Minimal RBC-Related and Antigen Sink Liabilities, and Extended Half Life in Comparison with Benchmark Clinical Antibodies of the Same IgG Subclass by Cai, Bin, Nguyen, Aaron N, Zheng, Songmao, Shi, Jianfeng, Liu, Guizhong, Li, Yan, Du, Felix, Luo, Peter, Xu, Jiangchun

“…Binding of the CD47 membrane protein, overexpressed on many tumor types, to the SIRPα inhibitory receptor on myeloid cells results in the inhibition of the…”
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Prediction of Disease-free Survival in Hepatocellular Carcinoma by Gene Expression Profiling by Lim, Ho-Yeong, Sohn, Insuk, Deng, Shibing, Lee, Jeeyun, Jung, Sin Ho, Mao, Mao, Xu, Jiangchun, Wang, Kai, Shi, Stephanie, Joh, Jae Won, Choi, Yoon La, Park, Cheol-Keun

“…Background Progression of hepatocellular carcinoma (HCC) often leads to vascular invasion and intrahepatic metastasis, which correlate with recurrence after…”
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Eye-gaze tracking system based on particle swarm optimization and BP neural network by Liling Yu, Jiangchun Xu, Shengwang Huang

“…In order to enhance the practicability and accuracy of the eye-gaze tracking system, a new type low pixel eye feature point location method is adopted. This…”
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