Search Results - "Jiang, Zebo"
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Tetrandrine activates STING/TBK1/IRF3 pathway to potentiate anti-PD-1 immunotherapy efficacy in non-small cell lung cancer
Published in Pharmacological research (01-09-2024)“…The efficacy of PD-1 therapy in non-small cell lung cancer (NSCLC) patients remains unsatisfactory. Activating the STING pathway is a promising strategy to…”
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Cordycepin Inhibits Drug-resistance Non-small Cell Lung Cancer Progression by Activating AMPK Signaling Pathway
Published in Pharmacological research (01-06-2019)“…[Display omitted] Lung cancer is the most commonly diagnosed cancer worldwide and it is also the most leading cause of cancer-related deaths. Although multiple…”
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Longitudinal high-dimensional analysis identifies immune features associating with response to anti-PD-1 immunotherapy
Published in Nature communications (22-08-2023)“…Response to immunotherapy widely varies among cancer patients and identification of parameters associating with favourable outcome is of great interest. Here…”
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Anti-breast cancer-induced cardiomyopathy: Mechanisms and future directions
Published in Biomedicine & pharmacotherapy (01-10-2023)“…With the progression of tumor treatment, the 5-year survival rate of breast cancer is close to 90%. Cardiovascular toxicity caused by chemotherapy has become a…”
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Immunity: Psoriasis comorbid with atherosclerosis
Published in Frontiers in immunology (15-12-2022)“…Psoriasis is an immune-mediated, persistent inflammatory disease with a genetic predisposition, and the involvement of multiple organs in psoriasis remains…”
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Herbal formula BaWeiBaiDuSan alleviates polymicrobial sepsis-induced liver injury via increasing the gut microbiota Lactobacillus johnsonii and regulating macrophage anti-inflammatory activity in mice
Published in Acta pharmaceutica Sinica. B (01-03-2023)“…Sepsis-induced liver injury (SILI) is an important cause of septicemia deaths. BaWeiBaiDuSan (BWBDS) was extracted from a formula of Panax ginseng C. A. Meyer,…”
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Novel STING-targeted PET radiotracer for alert and therapeutic evaluation of acute lung injury
Published in Acta pharmaceutica Sinica. B (01-05-2023)“…Acute lung injury (ALI), as a common clinical emergency, is pulmonary edema and diffuse lung infiltration caused by inflammation. The lack of non-invasive…”
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Identification of a Novel Protein Arginine Methyltransferase 5 Inhibitor in Non-small Cell Lung Cancer by Structure-Based Virtual Screening
Published in Frontiers in pharmacology (01-03-2018)“…Protein arginine methyltransferase 5 (PRMT5) is able to regulate gene transcription by catalyzing the symmetrical dimethylation of arginine residue of histone,…”
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Krukovine Suppresses KRAS-Mutated Lung Cancer Cell Growth and Proliferation by Inhibiting the RAF-ERK Pathway and Inactivating AKT Pathway
Published in Frontiers in pharmacology (22-08-2018)“…Oncogenic activation of the KRAS gene via point mutations occurs in 20-30% of patients with non-small cell lung cancer (NSCLC). The RAS-RAF-ERK and…”
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Author correction to ‘Herbal formula BaWeiBaiDuSan alleviates polymicrobial sepsis-induced liver injury via increasing the gut microbiota Lactobacillus johnsonii and regulating macrophage anti-inflammatory activity in mice’ [Acta Pharmaceutica Sinica B 13 (2023) 1164–1179]
Published in Acta pharmaceutica Sinica. B (01-08-2023)Get full text
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Gossypol Inhibits Non-small Cell Lung Cancer Cells Proliferation by Targeting EGFRL858R/T790M
Published in Frontiers in pharmacology (09-07-2018)“…Background: Overexpression of epidermal growth factor receptor (EGFR) has been reported to be implicated in the pathogenesis of non-small cell lung cancer…”
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Ginseng polysaccharides alter the gut microbiota and kynurenine/tryptophan ratio, potentiating the antitumour effect of antiprogrammed cell death 1/programmed cell death ligand 1 (anti-PD-1/PD-L1) immunotherapy
Published in Gut (01-04-2022)“…Programmed death 1 and its ligand 1 (PD-1/PD-L1) immunotherapy is promising for late-stage lung cancer treatment, however, the response rate needs to be…”
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STING-targeted PET tracer for early assessment of tumor immunogenicity in colorectal cancer after chemotherapy
Published in European journal of nuclear medicine and molecular imaging (01-02-2024)“…Purpose To optimize chemotherapy regimens and improve the effectiveness of chemotherapy combined with immunotherapy, a PET tracer specifically targeting the…”
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pH-sensitive molybdenum (Mo)-based polyoxometalate nanoclusters have therapeutic efficacy in inflammatory bowel disease by counteracting ferroptosis
Published in Pharmacological research (01-02-2023)“…Current therapeutic drugs for ulcerative colitis (UC) remained inadequate due to drug dependence and unacceptable adverse events. Reactive oxygen species (ROS)…”
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STING agonist-based hydrogel enhances immune activation in synergy with radiofrequency ablation for hepatocellular carcinoma treatment
Published in Journal of controlled release (01-05-2024)“…Immunosuppression caused by incomplete radiofrequency ablation (iRFA) is a crucial factor affecting the effectiveness of RFA for solid tumors. However, little…”
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Bi/Se-Based Nanotherapeutics Sensitize CT Image-Guided Stereotactic Body Radiotherapy through Reprogramming the Microenvironment of Hepatocellular Carcinoma
Published in ACS applied materials & interfaces (15-09-2021)“…The particular characteristics of hypoxia, immune suppression in the tumor microenvironment, and the lack of accurate imaging guidance lead to the limited…”
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Modulation of gut microbiota to overcome resistance to immune checkpoint blockade in cancer immunotherapy
Published in Current opinion in pharmacology (01-10-2020)“…[Display omitted] Immune checkpoint blockade therapies that target CTLA-4 and PD-1/PD-L1 have ushered in a new era of cancer treatment. Nevertheless, a…”
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Artificial intelligence-based collaborative filtering method with ensemble learning for personalized lung cancer medicine without genetic sequencing
Published in Pharmacological research (01-10-2020)“…[Display omitted] In personalized medicine, many factors influence the choice of compounds. Hence, the selection of suitable medicine for patients with…”
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Lu3+-based nanoprobe for virtual non-contrast CT imaging of hepatocellular carcinoma
Published in Journal of controlled release (01-09-2022)“…Transcatheter arterial chemoembolization (TACE), the mainstream treatment for hepatocellular carcinoma (HCC), is a method of blocking tumor blood vessels with…”
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Inhibition of JNK/c-Jun-ATF2 Overcomes Cisplatin Resistance in Liver Cancer through down-Regulating Galectin-1
Published in International journal of biological sciences (01-01-2023)“…Due to drug resistance, the clinical response to cisplatin (CDDP) from patients with liver cancer is unsatisfactory. The alleviation or overcoming of CDDP…”
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