Search Results - "Jiang, Youxing"

Structural mechanisms of gating and selectivity of human rod CNGA1 channel by Xue, Jing, Han, Yan, Zeng, Weizhong, Wang, Yan, Jiang, Youxing

“…Mammalian cyclic nucleotide-gated (CNG) channels play an essential role in the signal transduction of the visual and olfactory sensory systems. Here we reveal…”
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Tuning the ion selectivity of two-pore channels by Guo, Jiangtao, Zeng, Weizhong, Jiang, Youxing

“…Organellar two-pore channels (TPCs) contain two copies of a Shaker-like six-transmembrane (6-TM) domain in each subunit and are ubiquitously expressed in…”
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Structures of the calcium-activated, non-selective cation channel TRPM4 by Guo, Jiangtao, She, Ji, Zeng, Weizhong, Chen, Qingfeng, Bai, Xiao-chen, Jiang, Youxing

“…TRPM4 is a calcium-activated, phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P 2 ) -modulated, non-selective cation channel that belongs to the family of…”
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Structural Mechanism of EMRE-Dependent Gating of the Human Mitochondrial Calcium Uniporter by Wang, Yan, Nguyen, Nam X., She, Ji, Zeng, Weizhong, Yang, Yi, Bai, Xiao-chen, Jiang, Youxing

“…Mitochondrial calcium uptake is crucial to the regulation of eukaryotic Ca2+ homeostasis and is mediated by the mitochondrial calcium uniporter (MCU). While…”
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Structure of the voltage-gated two-pore channel TPC1 from Arabidopsis thaliana by Guo, Jiangtao, Zeng, Weizhong, Chen, Qingfeng, Lee, Changkeun, Chen, Liping, Yang, Yi, Cang, Chunlei, Ren, Dejian, Jiang, Youxing

“…Two-pore channels (TPCs) contain two copies of a Shaker -like six-transmembrane (6-TM) domain in each subunit and are ubiquitously expressed in both animals…”
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Cryo-EM structures of human ZnT8 in both outward- and inward-facing conformations by Xue, Jing, Xie, Tian, Zeng, Weizhong, Jiang, Youxing, Bai, Xiao-Chen

“…ZnT8 is a Zn /H antiporter that belongs to SLC30 family and plays an essential role in regulating Zn accumulation in the insulin secretory granules of…”
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Structure of mammalian endolysosomal TRPML1 channel in nanodiscs by Chen, Qingfeng, She, Ji, Zeng, Weizhong, Guo, Jiangtao, Xu, Haoxing, Bai, Xiao-chen, Jiang, Youxing

“…The structure of mouse transient receptor potential mucolipin 1 (TRPML1), a cation channel located within endosomal and lysosomal membranes, is resolved using…”
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Structure of the gating ring from the human large-conductance Ca2+-gated K+ channel by Wu, Yunkun, Yang, Yi, Ye, Sheng, Jiang, Youxing

“…Gating ring structure High-conductance Ca 2+ -gated K + (BK) channels are essential for many biological processes such as smooth muscle contraction and…”
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Structural mechanisms of phospholipid activation of the human TPC2 channel by She, Ji, Zeng, Weizhong, Guo, Jiangtao, Chen, Qingfeng, Bai, Xiao-Chen, Jiang, Youxing

“…Mammalian two-pore channels (TPCs) regulate the physiological functions of the endolysosome. Here we present cryo-EM structures of human TPC2 (HsTPC2), a…”
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TRPML1 gating modulation by allosteric mutations and lipids by Gan, Ninghai, Han, Yan, Zeng, Weizhong, Jiang, Youxing

“…Transient Receptor Potential Mucolipin 1 (TRPML1) is a lysosomal cation channel whose loss-of-function mutations directly cause the lysosomal storage disorder…”
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Structural mechanism of proton conduction in otopetrin proton channel by Gan, Ninghai, Zeng, Weizhong, Han, Yan, Chen, Qingfeng, Jiang, Youxing

“…The otopetrin (OTOP) proteins were recently characterized as extracellular proton-activated proton channels. Several recent OTOP channel structures…”
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Structural Insight into the Ion-Exchange Mechanism of the Sodium/Calcium Exchanger by Liao, Jun, Li, Hua, Zeng, Weizhong, Sauer, David B., Belmares, Ricardo, Jiang, Youxing

“…Sodium/calcium (Na⁺/Ca²⁺) exchangers (NCX) are membrane transporters that play an essential role in maintaining the homeostasis of cytosolic Ca²⁺ for cell…”
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High-resolution structure of the open NaK channel by Jiang, Youxing, Alam, Amer

“…Channel gating in tetrameric cation channels occurs as structural transitions that involve straightening and bending of inner helices at a conserved glycine…”
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Structural mechanisms of the human cardiac sodium-calcium exchanger NCX1 by Xue, Jing, Zeng, Weizhong, Han, Yan, John, Scott, Ottolia, Michela, Jiang, Youxing

“…Na + /Ca 2+ exchangers (NCX) transport Ca 2+ in or out of cells in exchange for Na + . They are ubiquitously expressed and play an essential role in…”
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Cryo-EM structure of a fungal mitochondrial calcium uniporter by Nguyen, Nam X., Armache, Jean-Paul, Lee, Changkeun, Yang, Yi, Zeng, Weizhong, Mootha, Vamsi K., Cheng, Yifan, Bai, Xiao-chen, Jiang, Youxing

“…The mitochondrial calcium uniporter (MCU) is a highly selective calcium channel localized to the inner mitochondrial membrane. Here, we describe the structure…”
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Sodium and potassium competition in potassium-selective and non-selective channels by Sauer, David B., Zeng, Weizhong, Canty, John, Lam, Yeeling, Jiang, Youxing

“…Potassium channels selectively conduct K + , primarily to the exclusion of Na + , despite the fact that both ions can bind within the selectivity filter. Here…”
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Structural insights into the Ca2+-dependent gating of the human mitochondrial calcium uniporter by Wang, Yan, Han, Yan, She, Ji, Nguyen, Nam X, Mootha, Vamsi K, Bai, Xiao-chen, Jiang, Youxing

“…Mitochondrial Ca 2+ uptake is mediated by an inner mitochondrial membrane protein called the mitochondrial calcium uniporter. In humans, the uniporter…”
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Structural analysis of ion selectivity in the NaK channel by Jiang, Youxing, Alam, Amer

“…Ion selectivity is as important to ion channel function as channel gating. Much of what is currently known about selectivity comes from structural studies of K…”
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Mechanism of extracellular ion exchange and binding-site occlusion in a sodium/calcium exchanger by Liao, Jun, Marinelli, Fabrizio, Lee, Changkeun, Huang, Yihe, Faraldo-Gómez, José D, Jiang, Youxing

“…A series of crystal structures and calculated free-energy landscapes of a Na + /Ca 2+ exchanger explain how its alternating-access mechanism is controlled by…”
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TMEM120A is a coenzyme A-binding membrane protein with structural similarities to ELOVL fatty acid elongase by Xue, Jing, Han, Yan, Baniasadi, Hamid, Zeng, Weizhong, Pei, Jimin, Grishin, Nick V, Wang, Junmei, Tu, Benjamin P, Jiang, Youxing

“…TMEM120A, also named as TACAN, is a novel membrane protein highly conserved in vertebrates and was recently proposed to be a mechanosensitive channel involved…”
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